Results 41 to 50 of about 191,272 (307)

Flow cytometry and chromosome numbers variation in argan tree Argania spinosa (L.) Skeels

Notulae Scientia Biologicae, 2023
Argania spinosa L. Skeels is an endemic species of west-central Morocco, which is characterized by a high diversity of morphological and genetic traits. It constitutes a natural resource for oleo-agro-sylvo-pastoral uses.
Ali EL BOUKHARI, Salma TABI, Abdelhamid EL MOUSADIK, Rachida EL BOULLANI, Abdelghani TAHIRI, Meriyem KOUFAN, Hamid BENYAHIA, Rachid BOUHARROUD, Naima AIT AABD   +8 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

B-Cell chronic lymphocytic leukemia fluorescence in situ hybridization panel findings at tertiary care hospital in Saudi Arabia

Journal of Applied Hematology, 2018
BACKGROUND/PURPOSE: B-cell-chronic lymphocytic leukemia (B-CLL) is the most common leukemia in the Western world and shows a remarkable heterogeneity in the clinical course.
Wedian Mustafa Rawas, Salem H Khalil, Emad E Ghabashi   +2 more
doaj   +1 more source

Incidence, outcomes, and risk factors of pleural effusion in patients receiving dasatinib therapy for Philadelphia chromosome-positive leukemia. [PDF]

, 2019
Dasatinib, a second-generation BCR-ABL1 tyrosine kinase inhibitor, is approved for the treatment of chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia, both as first-line therapy and after imatinib intolerance or ...
Abruzzese, Elisabetta, Cortes, Jorge E, Hochhaus, Andreas, Hughes, Timothy P, Laneuville, Pierre, Lipton, Jeffrey H, Paar, David, Rea, Delphine, Rousselot, Philippe, Shah, Neil P, Snyder, David S   +10 more
core   +2 more sources

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Karyotypic characterization of the pike, Esox lucius from the south Caspian Sea basin [PDF]

Iranian Journal of Animal Biosystematics, 2015
The karyotype of pike from Anzali lagoon in the south Caspian Sea basin have been investigated by examining metaphase chromosomes spreads obtained from gill epithelial and kidney cells.
Majidreza Khoshkholgh, Alireza Alavi, Sajad Nazari   +2 more
doaj   +1 more source

Cytogenetics and molecular cytogenetics in Hodgkin's disease

Annals of Oncology, 1996
For about 20 years we have known from cytogenetic studies that there is a clonal cell population in Hodgkin's disease. Most karyotypes are complexly aberrant and chromosome numbers typically lie in the hyperploid range. Some chromosome regions seem to be preferentially involved, but a chromosome aberration specific for Hodgkin's disease has not yet ...
J, Deerberg-Wittram, K, Weber-Matthiesen, B, Schlegelberger   +2 more
openaire   +2 more sources

Molecular cytogenetic characterisation of Salix viminalis L. using repetitive DNA sequences [PDF]

, 2013
Salix viminalis L. (2n=38) is a diploid dicot species belonging to the Salix genus of the Salicaceae family. This short-rotation woody crop is one of the most important renewable bioenergy resources worldwide.
Dudits, Dénes, Linc, Gabriella, Láng Molnár, Márta, Németh, Anna Viktória   +3 more
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Deciphering copy number variations and gene implications in an Egyptian cohort with autism spectrum disorders

BMC Medical Genomics
Background Genetic factors are major contributors to autism spectrum disorders (ASD), with copy number variations (CNVs) playing a significant role. Our objective was to identify and assess CNVs and their associated gene-level impacts in Egyptian ASD ...
Amal M. Mohamed, Ola M. Eid, Khalda S. Amr, Rana Mahrous, Maha Hemimi, Amal Elsaeid, Peter S. F. Erian, Sally Gharib, Shymaa H. Hussein, Phoebe M. Abd El-Massieh, Nagwa A. Meguid   +10 more
doaj   +1 more source