Results 31 to 40 of about 129,688 (299)
Molecular Genetics & Genomic Medicine, 2019 Background Pregnancy loss affects 10%–15% of pregnancies and is caused by several factors, maternal and fetal. Most common cause is chromosomal aneuploidy and has traditionally been detected by karyotyping product of conception and/or fetal tissue.
Kimia Najafi +12 more
doaj +1 more source
Clonal karyotype evolution involving ring chromosome 1 with myelodysplastic syndrome subtype RAEB-t progressing into acute leukemia [PDF]
, 2006 s Karyotypic evolution is a well-known phenomenon in patients with malignant hernatological disorders during disease progression. We describe a 50-year-old male patient who had originally presented with pancytopenia in October 1992.
Wunderlich, Bettina +18 more
core +1 more source
Genetic and epigenetic factors: Role in male infertility
Indian Journal of Urology, 2011 Genetic factors contribute upto 15%-30% cases of male infertility. Formation of spermatozoa occurs in a sequential manner with mitotic, meiotic, and postmeiotic differentiation phases each of which is controlled by an intricate genetic program.
M B Shamsi, K Kumar, R Dada
doaj +1 more source
, 2020 High cytogenetic risk abnormalities confer poor outcomes in multiple myeloma patients. In POLLUX, daratumumab/lenalidomide/dexamethasone (D-Rd) demonstrated significant clinical benefit versus lenalidomide/dexamethasone (Rd) in relapsed/refractory ...
Magen, H +14 more
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A karyomorphological comparison of seven species of Achillea L. from Kurdistan of Iran
Caryologia, 2023 We conducted the present study on seven important medicinal species of Achillea (in a total of 28 populations) in their natural habitats. The results indicated that the populations had a base number (x= 9) and the diploid, tetraploid, and hexaploidy ...
Fatemeh Nezhadi +4 more
doaj +1 more source
Cytogenetic analysis of uveal melanomas: a long-term experience [PDF]
, 2013 Background/aim: Cytogenetic profile of posterior uveal melanoma (mainly monosomy 3) is actually considered the most specific prognostic factor for uveal melanoma patients.
Parrozzani, Raffaele
core
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Fluorescence in situ hybridization to chromosomes as a tool to understand human and primate genome evolution [PDF]
, 2005 For the last 15 years molecular cytogenetic techniques have been extensively used to study primate evolution. Molecular probes were helpful to distinguish mammalian chromosomes and chromosome segments on the basis of their DNA content rather than solely ...
Wienberg, Johannes, Wienberg, J.
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Molecular cytogenetic characterisation of Salix viminalis L. using repetitive DNA sequences [PDF]
, 2013 Salix viminalis L. (2n=38) is a diploid dicot species belonging to the Salix genus of the Salicaceae family. This short-rotation woody crop is one of the most important renewable bioenergy resources worldwide.
Láng Molnár, Márta +3 more
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