Results 101 to 110 of about 2,444 (195)
Cytoglobin as a Marker of Hepatic Stellate Cell-derived Myofibroblasts
Frontiers in Physiology, 2015 Myofibroblasts play important roles in inflammation, fibrosis and tumorigenesis in chronically inflamed liver. Liver myofibroblasts originate from hepatic stellate cells, portal fibroblasts or mesothelial cells, and they are localized in and around ...
Norifumi eKawada
doaj +1 more source
Globin-based redox signaling [PDF]
, 2016 In recent years, moderate levels of reactive oxygen species (ROS) have become recognized as signaling cues that participate at all levels of cellular organization. Globins, with their redox-active heme iron and ubiquitous presence, seem ideally suited to
Braeckman, Bart, De Henau, Sasha
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Neuroglobin and Cytoglobin: Oxygen-Binding Proteins in Retinal Neurons
Investigative Ophthalmology & Visual Science, 2006 The goal of this study was to describe the detailed localization of the novel oxygen-binding molecules, neuroglobin (Ngb) and cytoglobin (Cygb), in mammalian retinas and to determine whether Ngb and Cygb are neuronal or glial proteins in the retina.Antibodies directed against Ngb and Cygb were used to examine their patterns of distribution in normal ...
Ostojić, Jelena +9 more
openaire +4 more sources
PLoS ONE, 2012 Globins occur in all kingdoms of life where they fulfill a wide variety of functions. In the past they used to be primarily characterized as oxygen transport/storage proteins, but since the discovery of new members of the globin family like neuroglobin ...
Lesley Tilleman +11 more
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A novel comparative pattern analysis approach identifies chronic alcohol mediated dysregulation of transcriptomic dynamics during liver regeneration. [PDF]
, 2016 BACKGROUND: Liver regeneration is inhibited by chronic ethanol consumption and this impaired repair response may contribute to the risk for alcoholic liver disease.
Dippold, Rachael P +4 more
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Cytoglobin in tumor hypoxia: novel insights into cancer suppression
Tumor Biology, 2014 Emerging new and intriguing roles of cytoglobin (Cygb) have attracted considerable attention of cancer researchers in recent years. Hypoxic upregulation of Cygb as well as its altered expression in various human cancers suggest another possible role of this newly discovered globin in tumor cell response under low oxygen tension.
Sankalpa, Chakraborty +2 more
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Nitrosative stress defences of the enterohepatic pathogenic bacterium Helicobacter pullorum [PDF]
, 2017 Helicobacter pullorum is an avian bacterium that causes gastroenteritis, intestinal bowel and hepatobiliary diseases in humans. Although H. pullorum has been shown to activate the mammalian innate immunity with release of nitric oxide (NO), the proteins ...
Boneca, Ivo G. +6 more
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Molecular analysis of the human cytoglobin mRNA isoforms
Journal of Inorganic BiochemistryMultiple functions have been proposed for the ubiquitously expressed vertebrate globin cytoglobin (Cygb), including nitric oxide (NO) metabolism, lipid peroxidation/signalling, superoxide dismutase activity, reactive oxygen/nitrogen species (RONS) scavenging, regulation of blood pressure, antifibrosis, and both tumour suppressor and oncogenic effects ...
Porto, Elena +3 more
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Hypoxic regulation of cytoglobin and neuroglobin expression in human normal and tumor tissues
Cancer Cell International, 2010 Background Cytoglobin (Cygb) and neuroglobin (Ngb) are recently identified globin molecules that are expressed in vertebrate tissues. Upregulation of Cygb and Ngb under hypoxic and/or ischemic conditions in vitro and in vivo increases cell survival ...
Emara Marwan +2 more
doaj +1 more source
Plant hemoglobins can be maintained in functional form by reduced flavins in the nuclei and confer differential tolerance to nitro-oxidative stress [PDF]
, 2013 39 Pags., 1 Tabl., 5 Figs., with Supplementary Supporting Information (1 Suppl. Tabl., 5 Suppl. Figs.). The definitive version is available at: http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-313XThe heme of bacteria, plant and animal ...
Becana Ausejo, Manuel +7 more
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