Results 81 to 90 of about 1,677 (171)

Cytoglobin: a potential marker for adipogenic differentiation in preadipocytes in vitro [PDF]

Cytotechnology, 2016
Obesity, mainly characterized by the excess fat storage, is a global health problem resulting in serious morbidity and mortality. Identification of molecular mechanisms in adipogenic differentiation pathway might lead to development of new strategies for diagnosis, prevention and therapy of obesity and associated diseases.
Ayşegül, Doğan, Selami, Demirci, Binnur, Kıratlı, Fikrettin, Şahin   +3 more
openaire   +2 more sources

Analyzing the role of ferroptosis in ribosome‐related bone marrow failure disorders: From pathophysiology to potential pharmacological exploitation

IUBMB Life, Volume 76, Issue 12, Page 1011-1034, December 2024.
Abstract Within the last decade, the scientific community has witnessed the importance of ferroptosis as a novel cascade of molecular events leading to cellular decisions of death distinct from apoptosis and other known forms of cell death. Notably, such non‐ apoptotic and iron‐dependent regulated cell death has been found to be intricately linked to ...
Aliki Papadimitriou‐Tsantarliotou, Chrysostomos Avgeros, Maria Konstantinidou, Ioannis S. Vizirianakis   +3 more
wiley   +1 more source

Electron transfer function versus oxygen delivery: a comparative study for several hexacoordinated globins across the animal kingdom. [PDF]

PLoS ONE, 2011
Caenorhabditis elegans globin GLB-26 (expressed from gene T22C1.2) has been studied in comparison with human neuroglobin (Ngb) and cytoglobin (Cygb) for its electron transfer properties. GLB-26 exhibits no reversible binding for O(2) and a relatively low
Laurent Kiger, Lesley Tilleman, Eva Geuens, David Hoogewijs, Christophe Lechauve, Luc Moens, Sylvia Dewilde, Michael C Marden   +7 more
doaj   +1 more source

Functional characterization of cytoglobin

, 2012
published_or_final_version ; Biological Sciences ; Doctoral ; Doctor of ...
openaire   +2 more sources

The Cellular and Subcellular Localization of Neuroglobin and Cytoglobin ‐ A Clue to Their Function? [PDF]

IUBMB Life, 2004
AbstractNeuroglobin and cytoglobin are recently discovered respiratory proteins of vertebrates with yet ill‐defined physiological functions. Neuroglobin is widely expressed in neurons, but not glia, in the vertebrate central and peripheral nervous systems. Other major expression sites are the retina and endocrine tissues.
Thomas, Hankeln, Sylvia, Wystub, Tilmann, Laufs, Marc, Schmidt, Frank, Gerlach, Sigrid, Saaler-Reinhardt, Stefan, Reuss, Thorsten, Burmester   +7 more
openaire   +2 more sources

Haemoglobin Gene Repertoire in Teleost and Cichlid Fishes Shaped by Gene Duplications and Genome Rearrangements

Molecular Ecology, Volume 33, Issue 22, November 2024.
ABSTRACT Haemoglobin is a key molecule for oxygen transport in vertebrates. It exhibits remarkable gene diversity in teleost fishes, reflecting adaptation to various aquatic environments. In this study, we present the dynamic evolution of haemoglobin subunit genes based on a comparison of high‐quality genome assemblies of 24 vertebrate species ...
Dmytro Omelchenko, Arnold Roger Bitja‐Nyom, Michael Matschiner, Milan Malinsky, Adrian Indermaur, Walter Salzburger, Oldřich Bartoš, Zuzana Musilova   +7 more
wiley   +1 more source

Negative Correlation between Cytoglobin Expression and Intracellular ROS Levels in Human Skin Keloid Fibroblasts [PDF]

, 2019
BACKGROUND: In our previous study, we found higher cytoglobin (Cygb) expression in keloid than normal tissue. Cytoglobin is a new globin family protein which function is still being studied to date.
Fajri Marindra Siregar, Sri Widia Azraki Jusman, Novi Silvia Hardiany, Siregar, Fajri Marindra, Jusman, Sri Widia Azraki, Hardiany, Novi Silvia   +5 more
core   +1 more source

Diosmin: A promising phytochemical for functional foods, nutraceuticals and cancer therapy

Food Science &Nutrition, Volume 12, Issue 9, Page 6070-6092, September 2024.
The anticancer mechanisms of diosmin involve stimulating receptors, increasing ROS, and inducing cell death via the PI3K/Akt pathway. Diosmin upregulates p53 and p21, causing S‐phase cell cycle arrest, and activates caspase‐3, leading to apoptosis. Additionally, diosmin inhibits NF‐κB, reducing inflammation and angiogenesis, and promotes autophagy ...
Lubna Rahman, Ali Talha Khalil, Syed Ahsan Shahid, Zabta Khan Shinwari, Zainab M. Almarhoon, Amnah Alalmaie, Javad Sharifi‐Rad, Daniela Calina   +7 more
wiley   +1 more source

Phylogenetic analysis reveals wide distribution of globin X

Biology Direct, 2011
The vertebrate globin gene repertoire consists of seven members that differ in terms of structure, function and phyletic distribution. While hemoglobin, myoglobin, cytoglobin, and neuroglobin are present in almost all gnathostomes examined so far, other ...
Makałowski Wojciech, Dröge Jasmin
doaj   +1 more source

A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma

Scientific Reports, 2021
Cytoglobin (CYGB) is a ubiquitously expressed protein with a protective role against oxidative stress, fibrosis and tumor growth, shown to be transcriptionally regulated under hypoxic conditions.
Joey De Backer, Darko Maric, Matthias Bosman, Sylvia Dewilde, David Hoogewijs   +4 more
doaj   +1 more source