Results 61 to 70 of about 1,677 (171)

Cell cycle‐dependent regulation of cytoglobin by Skp2 [PDF]

FEBS Letters, 2017
Cytoglobin (Cygb) is a cellular haemoprotein belonging to the globin family with ambiguous biological functions. Downregulation of Cygb in many cancers is indicative of its tumour‐suppressive role. This is the first report showing the cell cycle regulation of Cygb, which was found to peak at G1 and rapidly decline in S phase. Importantly, Skp2‐mediated
Rince, John, Yama, Atri, Vaibhav, Chand, Neha, Jaiswal, Kritika, Raj, Alo, Nag   +5 more
openaire   +2 more sources

Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall

Nature Communications, 2017
The gaseous signalling molecule nitric oxide regulates vascular tone. Here, the authors show that nitric oxide is degraded by the enzyme cytoglobin in the vascular wall, and that mice lacking cytoglobin have reduced blood pressure and are less sensitive ...
Xiaoping Liu, Mohamed A. El-Mahdy, James Boslett, Saradhadevi Varadharaj, Craig Hemann, Tamer M. Abdelghany, Raed S. Ismail, Sean C. Little, Danlei Zhou, Le Thi Thanh Thuy, Norifumi Kawada, Jay L. Zweier   +11 more
doaj   +1 more source

Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-κB Pathway Inhibition

Frontiers in Molecular Neuroscience, 2019
Cytoglobin (Cygb) is a hexacoordinate protein, associated with the transport of oxygen, nitric oxide scavenging, tumor suppression and protection against oxidative stress and inflammation.
Bruna R. B. Gomes, Gabriela Luna S. de Sousa, Daniela Ott, Jolanta Murgott, Marcelo V. de Sousa, Paulo E. N. de Souza, Joachim Roth, Fabiane H. Veiga-Souza, Fabiane H. Veiga-Souza   +8 more
doaj   +1 more source

Cytoglobin inhibits non-thermal plasma-induced apoptosis in melanoma cells through regulation of the NRF2-mediated antioxidant response

Redox Biology, 2022
Melanoma arises from pigment-producing cells called melanocytes located in the basal layers of the epidermis of the skin. Cytoglobin (CYGB) is a ubiquitously expressed hexacoordinated globin that is highly enriched in melanocytes and frequently ...
Joey De Backer, Abraham Lin, Wim Vanden Berghe, Annemie Bogaerts, David Hoogewijs   +4 more
doaj   +1 more source

Cytoglobin as a biomarker in cancer:potential perspective for diagnosis and management [PDF]

, 2015
The search for biomarkers to detect the earliest glimpse of cancer has been one of the primary objectives of cancer research initiatives. These endeavours, in spite of constant clinical challenges, are now more focused as early cancer detection provides ...
Dyall, Sabrina, Neergheen-Bhunjun, Vidushi, Hodges, Nikolas, Bholah, Tatsha, Bahorun, Theeshan   +4 more
core   +1 more source

Intermediate Tyrosyl Radical and Amyloid Structure in Peroxide-Activated Cytoglobin. [PDF]

PLoS ONE, 2015
We characterized the peroxidase mechanism of recombinant rat brain cytoglobin (Cygb) challenged by hydrogen peroxide, tert-butylhydroperoxide and by cumene hydroperoxide. The peroxidase mechanism of Cygb is similar to that of myoglobin.
Juliana C Ferreira, Marcelo F Marcondes, Marcelo Y Icimoto, Thyago H S Cardoso, Aryane Tofanello, Felipe S Pessoto, Erica G A Miranda, Tatiana Prieto, Otaciro R Nascimento, Vitor Oliveira, Iseli L Nantes   +10 more
doaj   +1 more source

Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin

, 2008
Cytoglobin is a recently identified member of the mammalian globin family that is expressed in neuronal cells in the central and peripheral nervous system where its physiological role remains to be determined.
Subdha Dh, Graham, M, Dhanda, S, Hodges, Nikolas, Mark Graham, Innocent, N, Neal Innocent, Nikolos J. Hodges   +7 more
core   +1 more source

Microtubule‐Targeting Drugs Induce Mesenchymal–Epithelial Transition in Hepatic Stellate Cells

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background and Aims Liver fibrosis is a progressive pathological condition characterized by excessive extracellular matrix accumulation, primarily driven by activated hepatic stellate cells (HSCs). While molecular‐based strategies have been extensively explored for HSC deactivation, clinically effective therapies remain elusive.
Hayato Urushima, Tsutomu Matsubara, Hideto Yuasa, Atsuko Daikoku, Gu Qiongya, Hikaru Nakai, Chiho Kadono, Kazuo Ikeda   +7 more
wiley   +1 more source

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source