Results 51 to 60 of about 1,677 (171)
Phytotherapy Research, Volume 37, Issue 11, Page 4932-4962, November 2023., 2023 Phytochemicals treat liver fibrosis in chemicals induced in‐vivo and in‐vitro liver fibrosis models. MMPs are potential drug targets by novel natural drugs for treating hepatic fibrosis. MMPs regulate ECM turnover, fibrolysis, and stellate cell activation through alternative mechanisms.
Usman Sabir +2 more
wiley +1 more source
Hypoxia/Ischemia and the Regulation of Neuroglobin and Cytoglobin Expression [PDF]
IUBMB Life, 2004 AbstractIn analogy to hemoglobin (Hb) and myoglobin (Mb), neuroglobin (Ngb) and cytoglobin (Cygb) are supposed to be involved in oxygen (O2) storage and delivery. The Cygb gene harbours both conserved HREs and mRNA stabilization sites, strongly suggestive of an oxygen‐dependent regulation.
Fordel, E. +4 more
openaire +3 more sources
Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications
Advanced Science, Volume 10, Issue 30, October 26, 2023., 2023 This review explores nitric oxide's (NO) roles in physiology and pathology while considering its advantages and limitations. Progress in designing versatile materials as NO donors and carriers for bioavailability and function at target sites is discussed. It summarizes therapeutic potential, challenges, and prospects in biomedicine.
Syed Muntazir Andrabi +6 more
wiley +1 more source
Pharmaceuticals, 2022 Acute lung injury (ALI) is one of the adverse effects of the antineoplastic agent cisplatin (CIS). Oxidative stress, inflammation, and necroptosis are linked to the emergence of lung injury in various disorders.
Emad H. M. Hassanein +9 more
doaj +1 more source
Hayati Journal of Biosciences, 2023 Hypobaric hypoxia is situation that might occur to helicopter pilots in Indonesia who must fly at an altitude of more than 3,048 m such as in Papua. It can be dangerous because hypoxic condition can affect person's performance.
Wardaya Wardaya +3 more
doaj +1 more source
Calcineurin Activates Cytoglobin Transcription in Hypoxic Myocytes [PDF]
Journal of Biological Chemistry, 2009 Cardiac hypertrophy develops in response to a variety of cardiovascular stresses and results in activation of numerous signaling cascades and proteins. In the present study, we demonstrate that cytoglobin is a stress-responsive hemoprotein in the hypoxia-induced hypertrophic myocardium and it is transcriptionally regulated by calcineurin-dependent ...
Sarvjeet, Singh +6 more
openaire +2 more sources
Changes in cellular phenotype and resistance to cisplatin in an oral squamous carcinoma model over-expressing cytoglobin [PDF]
, 2016 Although cytoglobin is widely considered a tumour suppressor, re-expression plays a role in disease progression in a subset of oral squamous cell carcinomas (OSC), but the mechanism of action is not understood. In this thesis, we developed a new OSC cell
Thorne, Lorna Susan
core +6 more sources
Cytoglobin expression in rat kidney during exposure to systemic chronic hypoxia
Acta Biochimica Indonesiana, 2020 Background: The kidneys in physiological conditions are always in a state of relative hypoxia. Cytoglobin (Cygb) is the newest globin protein found of the globin family. One of the functions of Cygb is in oxygen supply.
Ika Superti Daruningrum +4 more
doaj +1 more source
Peroxidase Activity of Human Hemoproteins: Keeping the Fire under Control
Molecules, 2018 The heme in the active center of peroxidases reacts with hydrogen peroxide to form highly reactive intermediates, which then oxidize simple substances called peroxidase substrates.
Irina I. Vlasova
doaj +1 more source
Structure, function and the related mechanism of cytoglobin [PDF]
SCIENTIA SINICA Vitae, 2018 Cytoglobin (Cygb) is a hemeprotein belonging to the globin superfamily. It is mainly expressed in fibroblasts, cardiomyocytes and vascular smooth muscle cells. The main function of Cygb is unclear. It has been reported that Cygb is involved in oxygen storage, reactive oxygen species detoxification, collagen synthesis, nitric oxide (NO) metabolism ...
XiaoPing LIU, DanLei ZHOU, AiQin LUO
openaire +1 more source