Results 41 to 50 of about 1,106 (124)
Cancer Science, Volume 117, Issue 3, Page 670-682, March 2026.SPP1 was identified as a key driver of intratumoral fibrosis and hepatocellular carcinoma (HCC) progression through transcriptomic, histological, and functional analyses. Mechanistically, SPP1 promotes HSC activation and fibrosis via the SPP1–CD44–GLI1 axis, and pharmacologic inhibition of Hedgehog signaling effectively reduces tumor growth and ...
Atsushi Nara +16 more
wiley +1 more source
3D‐Printed Protein Models as an Educational Tool in Biochemistry Outreach
Biochemistry and Molecular Biology Education, Volume 54, Issue 1, Page 59-66, January/February 2026.ABSTRACT The abstract and complex nature of molecular biology often presents significant challenges for students at all levels of study. Traditional teaching methods, such as the use of 2D diagrams, may not fully convey the intricacies of these topics, leading to difficulties in comprehension and engagement. This study aimed to introduce 3D‐printed and
Oliver Osborne +2 more
wiley +1 more source
Neuroglobin and cytoglobin: two new members of globin family
Revista Brasileira de Hematologia e Hemoterapia, 2011 The globin family has long been defined by myoglobin and hemoglobin, proteins with the functions of oxygen storage and transportation, respectively. Recently, two new members of this family were discovered: neuroglobin present in neurons and retinal ...
Priscilla Tosqui +1 more
doaj +1 more source
Hepatology Research, Volume 55, Issue 11, Page 1425-1436, November 2025.ABSTRACT Chronic liver diseases (CLD) arising from various etiologies including viral hepatitis, excessive alcohol intake, alcoholic associated liver disease (ALD) and metabolic dysfunction‐associated steatotic liver disease (MASLD), are associated with persistent hepatic injury ultimately resulting in fibrosis.
Fidaa Bouezzedine +2 more
wiley +1 more source
Molecular Ecology, Volume 34, Issue 9, May 2025.ABSTRACT Coastal seawater hypoxia is increasing in temperate estuaries under global climate change, yet it is unknown how low oxygen conditions affect most estuarine species. We found that hypoxia has increased since the 1990s in an estuary hosting the sea anemone Nematostella vectensis (Jacques Cousteau National Estuarine Research Reserve, New Jersey,
Benjamin H. Glass +5 more
wiley +1 more source
Iron‐Histidine Coordination in Cytochrome b5: A Local Vibrational Mode Study
ChemPhysChem, Volume 26, Issue 7, April 1, 2025.Distal/proximal FeN bond strength and axial NFeN angle stiffness in a series of cytochrome b5s, isolated from different species such as bacteria, animals, and human were investigated with our local vibrational mode analysis combined with QM/MM calculations.
Marek Freindorf +2 more
wiley +1 more source
PLoS ONE, 2017 Liver fibrosis, a common pathological process of chronic liver diseases, is the final stage of liver dysfunction that has severely deleterious impact on human health. Cytoglobin was first discovered in 2001 by proteomic analysis in rat stellate cells and
Gaotai Cai +5 more
doaj +1 more source
Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species
Oncogenesis, 2022 Pancreatic cancer is a highly challenging malignancy with extremely poor prognosis. Cytoglobin (CYGB), a hemeprotein involved in liver fibrosis and cancer development, is expressed in pericytes of all organs.
Dinh Viet Hoang +17 more
doaj +1 more source
Role of PNPLA3 in Hepatic Stellate Cells and Hepatic Cellular Crosstalk
Liver International, Volume 45, Issue 4, April 2025.ABSTRACT Aims Since its discovery, the patatin‐like phospholipase domain containing 3 (PNPLA3) (rs738409 C>G p.I148M) variant has been studied extensively to unravel its molecular function. Although several studies proved a causal relationship between the PNPLA3 I148M variant and MASLD development and particularly fibrosis, the pathological mechanisms ...
Maria Castanho Martins +5 more
wiley +1 more source
Electroanalysis, Volume 36, Issue 12, December 2024.Abstract In medical diagnostics, variations in hemoglobin levels can reveal a variety of prevalent health conditions. Abnormal hemoglobin is known to be connected with diseases like anemia, diabetes, hematemesis, hematuria, and hemoglobinuria. Consequently, there is a significant demand for advanced detection technologies and precise methodologies to ...
Hilal Özçelik +5 more
wiley +1 more source