Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin [PDF]
Scientific Reports, 2021 Cytoglobin is important in the progression of oral squamous cell carcinoma but the molecular and cellular basis remain to be elucidated. In the current study, we develop a new cell model to study the function of cytoglobin in oral squamous carcinoma and ...
Lorna S. Thorne +6 more
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Cytoglobin conformations and disulfide bond formation [PDF]
The FEBS Journal, 2010 The oligomeric state and kinetics of ligand binding were measured for wild‐type cytoglobin. Cytoglobin has the classical globin fold, with an extension at each extremity of about 20 residues. The extended length of cytoglobin leads to an ambiguous interpretation of its oligomeric state. Although the hydrodynamic diameter corresponds to that of a dimer,
Lechauve, Christophe +7 more
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Cytoglobin in Hepatic Stellate Cells Plays Anti-Fibrotic Role in Chronic Liver Injury [PDF]
AntioxidantsCytoglobin (Cygb) was discovered in 2001 as a cytoplasmic globin predominantly expressed in hepatic stellate cells (HSCs). While its initial physiological role remained elusive, subsequent studies using Cygb-deficient mouse models of liver injury have ...
Norifumi Kawada
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Expression, Purification, and Crystallization of Neuro- and Cytoglobin
, 2008 Neuroglobin and cytoglobin, members of the globin family, are present in vertebrate cells at very low concentrations. As the function of both proteins is still a matter of debate, it is very important to be able to produce and purify these proteins, and in general all members of the globin family, to homogeneity.
DEWILDE S +7 more
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Role of Endosialin/CD248 and Cytoglobin in liver fibrosis [PDF]
Al-Azhar International Medical Journal, 2023 Background - Chronic liver diseases are a major global health burden. Cygb, the fourth human globin is most abundantly expressed in HSCs among liver cells. CYGB can bind with oxygen and nitric oxide, and is believed to protect HSCs from ROS.
Mahmoud mansour +4 more
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Melanoma transition is frequently accompanied by a loss of cytoglobin expression in melanocytes: a novel expression site of cytoglobin. [PDF]
PLoS ONE, 2014 The tissue distribution and function of hemoglobin or myoglobin are well known; however, a newly found cytoglobin (CYGB), which also belongs to the globin family, remains to be characterized.
Yoshihiko Fujita +8 more
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Distribution of cytoglobin in the mouse brain [PDF]
Frontiers in Neuroanatomy, 2016 Cytoglobin (Cygb) is a vertebrate globin with so far poorly defined function. It is expressed in the fibroblast cell-lineage but has also been found in neurons.
Stefan eReuss +4 more
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Lipid binding to cytoglobin leads to a change in haem co-ordination: a role for cytoglobin in lipid signalling of oxidative stress [PDF]
Biochemical Journal, 2011 Cytoglobin is a recently discovered hexa-co-ordinate haemoglobin that does not appear to function as a classical oxygen-binding protein. Its function is unknown and studies on the effects of changes in its expression have not decisively determined its role within the cell.
Reeder, BJ, Svistunenko, DA, Wilson, MT
openaire +4 more sources
Role of Nrf2/HO-1 and cytoglobin signaling in the protective effect of indole-3-acetic acid and chenodeoxycholic acid against kidney injury induced by valproate [PDF]
HeliyonBackground: Purpose: Valproate (VPA) is an antiepileptic drug widely used to treat various psychiatric and neurological disorders. Although its use is generally considered safe, chronic administration may lead to kidney injury.
Ahlam M. Alhusaini +9 more
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Therapeutic Potential of Cytoglobin and Neuroglobin in Oxidative Stress-Driven Liver Diseases [PDF]
AntioxidantsChronic liver diseases, including fibrosis and hepatocellular carcinoma (HCC), are primarily driven by oxidative stress, yet traditional antioxidant therapies often lack the specificity and efficacy required for clinical success.
Le Thi Thanh Thuy +7 more
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