Regulation of DNA damage and transcriptional output in the vasculature through a cytoglobin-HMGB2 axis [PDF]
Redox Biology, 2023 Identifying novel regulators of vascular smooth muscle cell function is necessary to further understand cardiovascular diseases. We previously identified cytoglobin, a hemoglobin homolog, with myogenic and cytoprotective roles in the vasculature.
David Jourd'Heuil +2 more
exaly +5 more sources
Cytoglobin scavenges intracellular hydrogen peroxide and regulates redox signals in the vasculature [PDF]
Redox BiologyThe oxidant hydrogen peroxide (H2O2) serves as a signaling molecule that alters many aspects of cardiovascular functions and contributes to cardiovascular diseases.
Joshua J Coon +2 more
exaly +5 more sources
Modulating Nitric Oxide Dioxygenase and Nitrite Reductase of Cytoglobin through Point Mutations [PDF]
Antioxidants, 2022 Cytoglobin is a hexacoordinate hemoglobin with physiological roles that are not clearly understood. Previously proposed physiological functions include nitric oxide regulation, oxygen sensing, or/and protection against oxidative stress under hypoxic ...
John Ukeri +2 more
doaj +4 more sources
Cytoglobin regulates NO-dependent cilia motility and organ laterality during development [PDF]
Nature Communications, 2023 Cytoglobin is a heme protein with unresolved physiological function. Genetic deletion of zebrafish cytoglobin (cygb2) causes developmental defects in left-right cardiac determination, which in humans is associated with defects in ciliary function and low
Elizabeth R. Rochon +12 more
doaj +3 more sources
Emerging perspectives on cytoglobin, beyond NO dioxygenase and peroxidase
Redox Biology, 2020 Cytoglobin is an evolutionary ancient hemoglobin with poor functional annotation. Rather than constrained to penta coordination, cytoglobin's heme iron may exist either as a penta or hexacoordinated arrangement when exposed to different intracellular ...
David Jourd'Heuil, Frances L Jourd'Heuil
exaly +5 more sources
Neuronal Cytoglobin in the Auditory Brainstem of Rat and Mouse: Distribution, Cochlear Projection, and Nitric Oxide Production [PDF]
Brain Sciences, 2023 Cytoglobin (Cygb), a hemoprotein of the globin family, is expressed in the supportive tissue cells of the fibroblast lineage and in distinct neuronal cell populations. The expression pattern and regulatory parameters of fibroblasts and related cells were
Stefan Reuss +3 more
doaj +3 more sources
Neuroglobin and Cytoglobin in Mammalian Nervous Systems: About Distribution, Regulation, Function, and Some Open Questions [PDF]
Brain SciencesGlobins are a class of globular proteins that function in the transportation or storage of oxygen. They are critical for cellular metabolism. Notable examples include hemoglobin, which is found in red blood cells, and myoglobin, which is present in ...
Stefan Reuss
doaj +3 more sources
Neuroglobin and cytoglobin: two new members of globin family [PDF]
Revista Brasileira de Hematologia e Hemoterapia, 2011 The globin family has long been defined by myoglobin and hemoglobin, proteins with the functions of oxygen storage and transportation, respectively. Recently, two new members of this family were discovered: neuroglobin present in neurons and retinal ...
Priscilla Tosqui +1 more
doaj +7 more sources
Effect of the distal histidine on the peroxidatic activity of monomeric cytoglobin [v1; ref status: indexed, http://f1000r.es/4xg] [PDF]
F1000Research, 2015 The reaction of hydrogen peroxide with ferric human cytoglobin and a number of distal histidine variants were studied. The peroxidase activity of the monomeric wildtype protein with an internal disulfide bond, likely to be the form of the protein in vivo,
Penny Beckerson +2 more
doaj +6 more sources
Protection from intracellular oxidative stress by cytoglobin in normal and cancerous oesophageal cells. [PDF]
PLoS ONE, 2012 Cytoglobin is an intracellular globin of unknown function that is expressed mostly in cells of a myofibroblast lineage. Possible functions of cytoglobin include buffering of intracellular oxygen and detoxification of reactive oxygen species.
Fiona E McRonald +2 more
doaj +3 more sources