Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions. [PDF]
MedComm (2020)We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Qu J +8 more
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Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity [PDF]
Molecular BrainUnderstanding the mechanisms of synaptic plasticity is crucial for elucidating how the brain adapts to internal and external stimuli. A key objective of plasticity is maintaining physiological activity states during perturbations by adjusting synaptic ...
Maximilian Lenz +7 more
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Cytoglobin overexpression facilitates proliferation and migration of vascular smooth muscle cells [PDF]
Archives of Biological Sciences, 2020 Cytoglobin, a recently discovered globin, is expressed in vascular smooth muscle cells (VSMCs). Loss of cytoglobin provides a protective effect on vascular reconstruction but the effect of its overexpression is unclear.
Li Lei +5 more
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Regulation of nitrite reductase and lipid binding properties of cytoglobin by surface and distal histidine mutations [PDF]
Nitric Oxide - Biology and Chemistry, 2022 Taylor N Ayers +2 more
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Protection from intracellular oxidative stress by cytoglobin in normal and cancerous oesophageal cells. [PDF]
PLoS ONE, 2012 Cytoglobin is an intracellular globin of unknown function that is expressed mostly in cells of a myofibroblast lineage. Possible functions of cytoglobin include buffering of intracellular oxygen and detoxification of reactive oxygen species.
Fiona E McRonald +2 more
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Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin
Scientific Reports, 2021 Cytoglobin is important in the progression of oral squamous cell carcinoma but the molecular and cellular basis remain to be elucidated. In the current study, we develop a new cell model to study the function of cytoglobin in oral squamous carcinoma and ...
Lorna S. Thorne +6 more
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Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis [PDF]
Clinical and Molecular Hepatology, 2020 Cytoglobin (Cygb), a stellate cell-specific globin, has recently drawn attention due to its association with liver fibrosis. In the livers of both humans and rodents, Cygb is expressed only in stellate cells and can be utilized as a marker to distinguish
Le Thi Thanh Thuy +2 more
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Phylogeny of Echinoderm Hemoglobins. [PDF]
PLoS ONE, 2015 Recent genomic information has revealed that neuroglobin and cytoglobin are the two principal lineages of vertebrate hemoglobins, with the latter encompassing the familiar myoglobin and α-globin/β-globin tetramer hemoglobin, and several minor groups.
Ana B Christensen +9 more
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Role of Endosialin/CD248 and Cytoglobin in liver fibrosis [PDF]
Al-Azhar International Medical Journal, 2023 Background - Chronic liver diseases are a major global health burden. Cygb, the fourth human globin is most abundantly expressed in HSCs among liver cells. CYGB can bind with oxygen and nitric oxide, and is believed to protect HSCs from ROS.
Mahmoud mansour +4 more
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Computational and Structural Biotechnology Journal, 2020 While the functions of the recently discovered cytoglobin, ubiquitously expressed in vertebrate tissues, remain uncertain, Antarctic fish provide unparalleled models to study novel protein traits that may arise from cold adaptation.
Daniela Giordano +15 more
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