Results 31 to 40 of about 1,106 (124)

Oxidative Stress, Hypoxia-Inducible Factor-1α, and Nuclear Factor-Erythroid 2-Related Factor 2 in the Hearts of Rats Exposed to Intermittent Hypobaric Hypoxia

Hayati Journal of Biosciences, 2023
Hypobaric hypoxia is situation that might occur to helicopter pilots in Indonesia who must fly at an altitude of more than 3,048 m such as in Papua. It can be dangerous because hypoxic condition can affect person's performance.
Wardaya Wardaya, Wawan Mulyawan, Sri Widia A Jusman, Mohamad Sadikin   +3 more
doaj   +1 more source

Cytoglobin expression in rat kidney during exposure to systemic chronic hypoxia

Acta Biochimica Indonesiana, 2020
Background:  The kidneys in physiological conditions are always in a state of relative hypoxia. Cytoglobin (Cygb) is the newest globin protein found of the globin family. One of the functions of Cygb is in oxygen supply.
Ika Superti Daruningrum, Ani Retno Prijanti, Ninik Mudjihartini, Mohamad Sadikin, Sri Widia A Jusman   +4 more
doaj   +1 more source

Peroxidase Activity of Human Hemoproteins: Keeping the Fire under Control

Molecules, 2018
The heme in the active center of peroxidases reacts with hydrogen peroxide to form highly reactive intermediates, which then oxidize simple substances called peroxidase substrates.
Irina I. Vlasova
doaj   +1 more source

Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall

Nature Communications, 2017
The gaseous signalling molecule nitric oxide regulates vascular tone. Here, the authors show that nitric oxide is degraded by the enzyme cytoglobin in the vascular wall, and that mice lacking cytoglobin have reduced blood pressure and are less sensitive ...
Xiaoping Liu, Mohamed A. El-Mahdy, James Boslett, Saradhadevi Varadharaj, Craig Hemann, Tamer M. Abdelghany, Raed S. Ismail, Sean C. Little, Danlei Zhou, Le Thi Thanh Thuy, Norifumi Kawada, Jay L. Zweier   +11 more
doaj   +1 more source

Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-κB Pathway Inhibition

Frontiers in Molecular Neuroscience, 2019
Cytoglobin (Cygb) is a hexacoordinate protein, associated with the transport of oxygen, nitric oxide scavenging, tumor suppression and protection against oxidative stress and inflammation.
Bruna R. B. Gomes, Gabriela Luna S. de Sousa, Daniela Ott, Jolanta Murgott, Marcelo V. de Sousa, Paulo E. N. de Souza, Joachim Roth, Fabiane H. Veiga-Souza, Fabiane H. Veiga-Souza   +8 more
doaj   +1 more source

Melanoma transition is frequently accompanied by a loss of cytoglobin expression in melanocytes: a novel expression site of cytoglobin. [PDF]

PLoS ONE, 2014
The tissue distribution and function of hemoglobin or myoglobin are well known; however, a newly found cytoglobin (CYGB), which also belongs to the globin family, remains to be characterized.
Yoshihiko Fujita, Satoshi Koinuma, Marco A De Velasco, Jan Bolz, Yosuke Togashi, Masato Terashima, Hidetoshi Hayashi, Takuya Matsuo, Kazuto Nishio   +8 more
doaj   +1 more source

Cytoglobin inhibits non-thermal plasma-induced apoptosis in melanoma cells through regulation of the NRF2-mediated antioxidant response

Redox Biology, 2022
Melanoma arises from pigment-producing cells called melanocytes located in the basal layers of the epidermis of the skin. Cytoglobin (CYGB) is a ubiquitously expressed hexacoordinated globin that is highly enriched in melanocytes and frequently ...
Joey De Backer, Abraham Lin, Wim Vanden Berghe, Annemie Bogaerts, David Hoogewijs   +4 more
doaj   +1 more source

Intermediate Tyrosyl Radical and Amyloid Structure in Peroxide-Activated Cytoglobin. [PDF]

PLoS ONE, 2015
We characterized the peroxidase mechanism of recombinant rat brain cytoglobin (Cygb) challenged by hydrogen peroxide, tert-butylhydroperoxide and by cumene hydroperoxide. The peroxidase mechanism of Cygb is similar to that of myoglobin.
Juliana C Ferreira, Marcelo F Marcondes, Marcelo Y Icimoto, Thyago H S Cardoso, Aryane Tofanello, Felipe S Pessoto, Erica G A Miranda, Tatiana Prieto, Otaciro R Nascimento, Vitor Oliveira, Iseli L Nantes   +10 more
doaj   +1 more source

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source

Negative Correlation between Cytoglobin Expression and Intracellular ROS Levels in Human Skin Keloid Fibroblasts

Indonesian Biomedical Journal, 2019
BACKGROUND: In our previous study, we found higher cytoglobin (Cygb) expression in keloid than normal tissue. Cytoglobin is a new globin family protein which function is still being studied to date.
Fajri Marindra Siregar, Novi Silvia Hardiany, Sri Widia Azraki Jusman   +2 more
doaj   +1 more source