Results 111 to 120 of about 2,225,287 (343)

MODULATING THE INNATE IMMUNE RESPONSE TO ELECTROSPUN SCAFFOLDS AND POLYMER DEGRADATIVE BYPRODUCTS [PDF]

, 2017
Implanted biomaterials often induce inflammation that frequently leads to the foreign body response, fibrosis, and the failure of the implant. Thus, it is important to evaluate how cells interact with materials to promote a more regenerative response. It
Abebayehu, Daniel
core   +2 more sources

Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure. [PDF]

, 2017
Vδ2+ γδ T cells are semi-innate T cells that expand markedly following P. falciparum (Pf) infection in naïve adults, but are lost and become dysfunctional among children repeatedly exposed to malaria.
Bowen, Katherine, Boyle, Michelle J, Budker, Rachel, Dorsey, Grant, Farrington, Lila A, Feeney, Margaret E, Greenhouse, Bryan, Jagannathan, Prasanna, Kamya, Moses R, Katureebe, Agaba, Lutwama, Fredrick, McIntyre, Tara I, Musinguzi, Kenneth, Nalubega, Mayimuna, Naluwu, Kate, Nankya, Felistas, Rek, John, Sikyomu, Esther   +17 more
core   +2 more sources

Underlying Vulnerabilities to the Cytokine Storm and Adverse COVID-19 Outcomes in the Aging Immune System [PDF]

, 2020
Lolita S. Nidadavolu, Jeremy Walston
openalex   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Longitudinal, natural history study reveals the disease burden of idiopathic multicentric Castleman disease

Haematologica
Idiopathic multicentric Castleman disease (iMCD) is a rare hematologic disorder with heterogeneous presentations ranging from moderate constitutional symptoms to life-threatening multiorgan system involvement. iMCD patients present with vastly different
Mateo Sarmiento Bustamante, Sheila K. Pierson, Yue Ren, Adam Bagg, Joshua D. Brandstadter, Gordan Srkalovic, Natalie Mango, Daisy Alapat, Mary Jo Lechowicz, Hongzhe Li, Frits van Rhee, Megan S. Lim, David C. Fajgenbaum   +12 more
doaj   +1 more source

Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis [PDF]

, 2010
© 2010 Cascão et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
AF Mourao, AK Andersson, Ana F Mourão, Ana M Rodrigues, BW Kirkham, C Gabay, DY Chen, Elsa Vieira-Sousa, ER Vossenaar, FA Houssiau, FC Arnett, G Parsonage, H Kokkonen, Helena Canhão, Henrique S Rosário, HJ Kim, IC Chikanza, Inês Perpétuo, J Cedergren, J Duarte, J Pene, JE Fonseca, JE Fonseca, JF Fries, Joaquim Polido-Pereira, João E Fonseca, K Nagatani, L Petrovic-Rackov, LA Joosten, LK Assi, LK Stamp, Luis Graca, M al-Janadi, M Chabaud, M Pelletier, Maria M Souto-Carneiro, ML Prevoo, Mário V Queiroz, P Barrera, P Weinmann, P Youinou, PE Poubelle, R Cascao, R Cascao, R Segal, RA Moura, Rita A Moura, Rita Cascão, S Kotake, SC Liang, TJ Smeets   +50 more
core   +3 more sources

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Effect of 3-Month Tai Chi Chuan on Heart Rate Variability, Blood Lipid and Cytokine Profiles in Middle-Aged and Elderly Individuals

International Journal of Gerontology, 2012
Background: To investigate the effect of 3 months of Tai Chi Chuan (TCC) training on heart rate variability, blood lipids and cytokine production in elderly people. Methods: This was a longitudinal study with 3 months of follow-up.
Wan-An Lu, Cheng-Deng Kuo
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

The potential role of T-cells and their interaction with antigen-presenting cells in mediating immunosuppression following trauma-hemorrhage [PDF]

, 2009
Objective: Trauma-hemorrhage results in depressed immune responses of antigen-presenting cells (APCs) and T-cells. Recent studies suggest a key role of depressed T-cell derived interferon (IFN)-g in this complex immune cell interaction.
Abraham E., Angele MK, Angele MK, Christian P. Schneider, Christian R. Walz, Christiane J. Bruns, de Saint-Vis B., Ertel W., Eugen Faist, Florian Loehe, Irshad H. Chaudry, Landy M., Markus Albertsmeier, Martin K. Angele, Ransom J., Siegfried Zedler   +15 more
core   +1 more source