Results 11 to 20 of about 1,542,731 (346)
New England Journal of Medicine, 2020 From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory (D.C.F.), and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy (C.H.J ...
D. Fajgenbaum, C. June
semanticscholar +3 more sources
Engineering cytokine therapeutics
Nature Reviews Bioengineering, 2023 Cytokines have pivotal roles in immunity, making them attractive as therapeutics for a variety of immune-related disorders. However, the widespread clinical use of cytokines has been limited by their short blood half-lives and severe side effects caused ...
Jeroen Deckers +15 more
semanticscholar +1 more source
Cytokine Storm in COVID-19: Immunopathogenesis and Therapy
Medicina, 2022 A cytokine storm is a hyperinflammatory state secondary to the excessive production of cytokines by a deregulated immune system. It manifests clinically as an influenza-like syndrome, which can be complicated by multi-organ failure and coagulopathy ...
C. Zanza +9 more
semanticscholar +1 more source
Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy
Nature reviews. Immunology, 2021 A paradigm shift has recently occurred in the field of cancer therapeutics. Traditional anticancer agents, such as chemotherapy, radiotherapy and small-molecule drugs targeting specific signalling pathways, have been joined by cellular immunotherapies ...
E. Morris +3 more
semanticscholar +1 more source
EMBO Molecular Medicine, 2020 Systemic toxicities have severely limited the clinical application of tumor necrosis factor (TNF) as an anticancer agent. Activity‐on‐Target cytokines (AcTakines) are a novel class of immunocytokines with improved therapeutic index.
Leander Huyghe +16 more
doaj +1 more source
The COVID-19 Cytokine Storm; What We Know So Far
Frontiers in Immunology, 2020 COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory ...
D. Ragab +4 more
semanticscholar +1 more source
Immunopathogenesis and treatment of cytokine storm in COVID-19
Theranostics, 2021 Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-inflammation, acute respiratory distress syndrome, and multiple organ failure.
Jae Seok Kim +7 more
semanticscholar +1 more source
Mediators of Inflammation, 2014 Recent evidence in biology and medicine has expanded the knowledge of cytokines function in many disease states and conditions as well as the severe adverse effects implicated in the escalated production associated with specific disease conditions.
Arkadiusz Orzechowski +3 more
openaire +5 more sources
Seminars in Immunopathology, 2017 Human coronaviruses (hCoVs) can be divided into low pathogenic and highly pathogenic coronaviruses. The low pathogenic CoVs infect the upper respiratory tract and cause mild, cold-like respiratory illness.
Rudragouda Channappanavar, S. Perlman
semanticscholar +1 more source
Frontiers in Immunology, 2023 The SARS-CoV-2 coronavirus, which causes a respiratory disease called COVID-19, has been declared a pandemic by the World Health Organization (WHO) and is still ongoing. Vaccination is the most important strategy to end the pandemic.
Yasmin Hisham +18 more
doaj +1 more source