Results 11 to 20 of about 799,218 (270)
Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy
Nature reviews. Immunology, 2021 A paradigm shift has recently occurred in the field of cancer therapeutics. Traditional anticancer agents, such as chemotherapy, radiotherapy and small-molecule drugs targeting specific signalling pathways, have been joined by cellular immunotherapies ...
E. Morris +3 more
semanticscholar +1 more source
The cytokine storm and COVID‐19
Journal of Medical Virology, 2020 Coronavirus disease 2019 (COVID‐19), which began in Wuhan, China, in December 2019, has caused a large global pandemic and poses a serious threat to public health.
B. Hu, Shaoying Huang, L. Yin
semanticscholar +1 more source
Immunopathogenesis and treatment of cytokine storm in COVID-19
Theranostics, 2021 Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-inflammation, acute respiratory distress syndrome, and multiple organ failure.
Jae Seok Kim +7 more
semanticscholar +1 more source
EMBO Molecular Medicine, 2020 Systemic toxicities have severely limited the clinical application of tumor necrosis factor (TNF) as an anticancer agent. Activity‐on‐Target cytokines (AcTakines) are a novel class of immunocytokines with improved therapeutic index.
Leander Huyghe +16 more
doaj +1 more source
The COVID-19 Cytokine Storm; What We Know So Far
Frontiers in Immunology, 2020 COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory ...
D. Ragab +4 more
semanticscholar +1 more source
Frontiers in Immunology, 2023 The SARS-CoV-2 coronavirus, which causes a respiratory disease called COVID-19, has been declared a pandemic by the World Health Organization (WHO) and is still ongoing. Vaccination is the most important strategy to end the pandemic.
Yasmin Hisham +18 more
doaj +1 more source
Seminars in Immunopathology, 2017 Human coronaviruses (hCoVs) can be divided into low pathogenic and highly pathogenic coronaviruses. The low pathogenic CoVs infect the upper respiratory tract and cause mild, cold-like respiratory illness.
Rudragouda Channappanavar, S. Perlman
semanticscholar +1 more source
New England Journal of Medicine, 2020 From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory (D.C.F.), and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy (C.H.J ...
D. Fajgenbaum, C. June
semanticscholar +1 more source
Scientific Reports, 2017 The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with GR’s ligand ...
Ioanna Petta +12 more
doaj +1 more source
The lymph node transcriptome of unicentric and idiopathic multicentric Castleman disease
Haematologica, 2022 Castleman disease is a polyclonal lymphoproliferative disorder characterized by unicentric or multicentric lymphadenopathy with characteristic histomorphological features, in addition to variable inflammatory symptomatology. The molecular mechanisms and
Pedro Horna +4 more
doaj +1 more source