Results 11 to 20 of about 2,162,469 (384)

Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment

Frontiers in Immunology, 2021
BackgroundInterferon beta (IFNβ) has been prescribed as a first-line disease-modifying therapy for relapsing-remitting multiple sclerosis (RRMS) for nearly three decades.
Priyanka Devi-Marulkar, Priyanka Devi-Marulkar, Carolina Moraes-Cabe, Carolina Moraes-Cabe, Pascal Campagne, Béatrice Corre, Béatrice Corre, Aida Meghraoui-Kheddar, Aida Meghraoui-Kheddar, Vincent Bondet, Alba Llibre, Darragh Duffy, Elisabeth Maillart, Caroline Papeix, Sandra Pellegrini, Sandra Pellegrini, Frédérique Michel, Frédérique Michel   +17 more
doaj   +1 more source

Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy

Nature reviews. Immunology, 2021
A paradigm shift has recently occurred in the field of cancer therapeutics. Traditional anticancer agents, such as chemotherapy, radiotherapy and small-molecule drugs targeting specific signalling pathways, have been joined by cellular immunotherapies ...
E. Morris, S. Neelapu, Theodoros Giavridis, M. Sadelain   +3 more
semanticscholar   +1 more source

The cytokine storm and COVID‐19

Journal of Medical Virology, 2020
Coronavirus disease 2019 (COVID‐19), which began in Wuhan, China, in December 2019, has caused a large global pandemic and poses a serious threat to public health.
B. Hu, Shaoying Huang, L. Yin
semanticscholar   +1 more source

A Paradoxical Effect of Interleukin-32 Isoforms on Cancer

Frontiers in Immunology, 2022
IL-32 plays a contradictory role such as tumor proliferation or suppressor in cancer development depending on the cancer type. In most cancers, it was found that the high expression of IL-32 was associated with more proliferative and progression of ...
Saerok Shim, Siyoung Lee, Siyoung Lee, Yasmin Hisham, Sinae Kim, Sinae Kim, Tam T. Nguyen, Tam T. Nguyen, Afeisha S. Taitt, Jihyeong Hwang, Hyunjhung Jhun, Ho-Young Park, Youngmin Lee, Su Cheong Yeom, Sang-Yeob Kim, Yong-Gil Kim, Soohyun Kim, Soohyun Kim   +17 more
doaj   +1 more source

Engineering cytokine therapeutics

Nature Reviews Bioengineering, 2023
Cytokines have pivotal roles in immunity, making them attractive as therapeutics for a variety of immune-related disorders. However, the widespread clinical use of cytokines has been limited by their short blood half-lives and severe side effects caused ...
Jeroen Deckers, Tom Anbergen, Ayla M. Hokke, Anne de Dreu, David P. Schrijver, Koen de Bruin, Y. C. Toner, Thijs J. Beldman, Jamie B. Spangler, T. D. de Greef, F. Grisoni, R. van der Meel, L. Joosten, M. Merkx, M. Netea, W. Mulder   +15 more
semanticscholar   +1 more source

Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production [PDF]

, 2017
IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17 and T follicular helper cells.
Cherukur, Yesesri, Dent, Alexander L., Hummel, Sarah A., Janga, Sarath Chandra, Kaplan, Mark H., Khan, Ibrahim, Meuris, Brice, Olson, Matthew R., Ulrich, Benjamin J.   +8 more
core   +1 more source

Global landscape of mouse and human cytokine transcriptional regulation [PDF]

, 2018
Cytokines are cell-to-cell signaling proteins that play a central role in immune development, pathogen responses, and diseases. Cytokines are highly regulated at the transcriptional level by combinations of transcription factors (TFs) that recruit ...
Fuxman Bass, Juan Ignacio, Gan, Kok Ann, Imedio, Alvaro Dafonte, Martinez, Melissa, Mehta, Shivani, Pro, Sebastian Carrasco, Santoso, Clarissa Stephanie, Sereda, Rebecca, Sewell, Jared Allan   +8 more
core   +1 more source

The COVID-19 Cytokine Storm; What We Know So Far

Frontiers in Immunology, 2020
COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory ...
D. Ragab, Haitham Salah Eldin, M. Taeimah, R. Khattab, R. Salem   +4 more
semanticscholar   +1 more source

Immunopathogenesis and treatment of cytokine storm in COVID-19

Theranostics, 2021
Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-inflammation, acute respiratory distress syndrome, and multiple organ failure.
Jae Seok Kim, Jun Young Lee, Jae-Won Yang, Keumwha Lee, M. Effenberger, W. Szpirt, A. Kronbichler, J. Shin   +7 more
semanticscholar   +1 more source

Safe eradication of large established tumors using neovasculature‐targeted tumor necrosis factor‐based therapies

EMBO Molecular Medicine, 2020
Systemic toxicities have severely limited the clinical application of tumor necrosis factor (TNF) as an anticancer agent. Activity‐on‐Target cytokines (AcTakines) are a novel class of immunocytokines with improved therapeutic index.
Leander Huyghe, Alexander Van Parys, Anje Cauwels, Sandra Van Lint, Stijn De Munter, Jennyfer Bultinck, Lennart Zabeau, Jeroen Hostens, An Goethals, Nele Vanderroost, Annick Verhee, Gilles Uzé, Niko Kley, Frank Peelman, Bart Vandekerckhove, Peter Brouckaert, Jan Tavernier   +16 more
doaj   +1 more source