Results 11 to 20 of about 5,332,469 (256)

Frontiers of cytokine engineering in CAR cell therapy for cancer [PDF]

Frontiers in Oncology
Chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy has revolutionized the treatment of hematologic malignancies, yet its efficacy in solid tumors remains limited by T cell exhaustion, restricted tumor infiltration, and an immunosuppressive
Yinghan Wu, Yinghan Wu, Yan-Ruide Li
doaj   +2 more sources

The JAK-STAT pathway: from structural biology to cytokine engineering [PDF]

Signal Transduction and Targeted Therapy
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway serves as a paradigm for signal transduction from the extracellular environment to the nucleus. It plays a pivotal role in physiological functions, such as hematopoiesis,
You Lv, Jianxun Qi, Jeffrey J. Babon, Longxing Cao, Guohuang Fan, Jiajia Lang, Jin Zhang, Pengbing Mi, Bostjan Kobe, Faming Wang   +9 more
doaj   +2 more sources

Engineering cytokines for cancer immunotherapy: a systematic review

Frontiers in Immunology, 2023
Cytokines are pivotal mediators of cell communication in the tumor microenvironment. Multiple cytokines are involved in the host antitumor response, but the production and function of these cytokines are usually dysregulated during malignant tumor ...
Yong Fu, Yong Fu, Renhong Tang, Renhong Tang, Xiaofeng Zhao, Xiaofeng Zhao   +5 more
doaj   +3 more sources

Advances in IL–2–based cancer immunotherapy and the synergistic role of stem–like CD8+ T cells in IL–2 and PD–1 combination therapy [PDF]

Frontiers in Immunology
IL–2 is a pleiotropic cytokine that plays a central role in the activation and proliferation of cytotoxic lymphocytes and regulatory T cells. Since its discovery in 1976 as a T–cell growth factor and its subsequent U.S.
Huiquan Gao, Shubo Wang, Huiru Yuan, Bingxiu Zhou, Fuxin Zhou   +4 more
doaj   +2 more sources

Large language model-guided CAR-T in silico platform for cytokine optimization in liver cancer with low antigen density [PDF]

Journal of Hematology & Oncology
CAR-T cell therapy has shown remarkable success in hematologic malignancies but remains limited in solid tumors such as liver cancer due to antigen heterogeneity, low target antigen density, and an immunosuppressive tumor microenvironment (TME). Cytokine
Haochen Nan, Xinyuan Shen, Youcheng Yang, Shubing Wang, Yan-Ruide Li   +4 more
doaj   +2 more sources

Structure-Guided Stapling of Dimeric Conformations and Linker Engineering Enhance Thermostability and Fine-Tune Activity of Bispecific VHH Cytokine Agonists

Antibodies
Background: Bispecific antibodies have emerged as a promising class of therapeutics, enabling simultaneous targeting of two distinct antigens. Single-domain antibodies (sdAbs) comprising camelid variable heavy chains (VHHs) provide a compact and ...
Raphael Trenker, Deepti Rokkam, Andrew Morin, Priyanka Balasubrahmanyam, Verenice Paredes, Ivan Cheng, Rene de Waal Malefyt, Martin Oft, Patrick Lupardus, Sandro Vivona   +9 more
doaj   +2 more sources

Cytokine fusion proteins for solid tumor therapy: mechanistic insights and clinical advances [PDF]

Journal of Hematology & Oncology
Cytokine fusion proteins are engineered biologics that combine functional modules, such as cytokines, antibodies, or albumin-binding domains, into a single molecular entity.
Yufang Wang, Jing Zheng, Zhen Li, Jingjing Qu, Yuqing Ren, Ziwan Cai, Yuekang Li, Wenjia Sun, Nan Jiang, Cuihong Cai, Kexin Ruan, Jiahe Shi, Zheya Zhang, Jianya Zhou   +13 more
doaj   +2 more sources

Next-generation CAR-NK cell therapy: engineering strategies, translational challenges, and future perspectives in cancer immunotherapy [PDF]

Cancer Cell International
Natural killer (NK) cells play a central role in innate immune surveillance and represent a promising platform for next-generation cancer immunotherapy.
Minoo Bakhtiari, Hamid Nickho, Mahmoud Mahmoudi, Fahimeh Lavi Arab, Akram Hoseinzadeh, Rasoul Baharlou   +5 more
doaj   +2 more sources

Correction: The JAK-STAT pathway: from structural biology to cytokine engineering [PDF]

Signal Transduction and Targeted Therapy
You Lv, Jianxun Qi, Jeffrey J. Babon, Longxing Cao, Guohuang Fan, Jiajia Lang, Jin Zhang, Pengbing Mi, Bostjan Kobe, Faming Wang   +9 more
doaj   +2 more sources

Insights into cytokine-receptor interactions from cytokine engineering. [PDF]

Annu Rev Immunol, 2015
Spangler JB, Moraga I, Mendoza JL, Garcia KC.   +3 more
europepmc   +2 more sources