Results 31 to 40 of about 5,332,469 (256)

Hydrogel Development for Rotator Cuff Repair

Frontiers in Bioengineering and Biotechnology, 2022
Rotator cuff tears (RCTs) are common in shoulder disease and disability. Despite significant advances in surgical repair techniques, 20–70% of patients still have postoperative rotator cuff dysfunction.
Zhengyu Xu, Yifei Fang, Yao Chen, Yushuang Zhao, Wei Wei, Wei Wei, Chong Teng   +6 more
doaj   +1 more source

Integrating Computational Design and Experimental Approaches for Next-Generation Biologics

Biomolecules
Therapeutic protein engineering has revolutionized medicine by enabling the development of highly specific and potent treatments for a wide range of diseases.
Ahrum Son, Jongham Park, Woojin Kim, Wonseok Lee, Yoonki Yoon, Jaeho Ji, Hyunsoo Kim   +6 more
doaj   +1 more source

Advances in rationally engineered cytokines for precision therapy in diabetic wound healing

Exploration of Immunology
Diabetic wound healing presents a unique and complex challenge due to the impaired cellular and molecular functions associated with diabetes. Chronic wounds in diabetic patients are characterized by prolonged inflammation, reduced angiogenesis, and ...
Xinxin Zhang, Tingting Wang, Xiangqing Fan, Tianze Zhang, Rui Qiu, Yuqi Wu, Meixia Wang, Yizhi Zhang, Meng Li, Na Cai, Ying Guan, Hong-Hui Wang   +11 more
doaj   +1 more source

CAR T cell therapy becomes CHIC: “cytokine help intensified CAR” T cells

Frontiers in Immunology, 2023
Chimeric antigen receptors (CARs) in the canonical “second generation” format provide two signals for inducing T cell effector functions; the primary “signal-1” is provided through the TCR CD3ζ chain and the “signal-2” through a linked costimulatory ...
Simone Thomas, Simone Thomas, Hinrich Abken, Hinrich Abken   +3 more
doaj   +1 more source

Critical role of TRIF and MyD88 in Mycobacterium tuberculosis Hsp70-mediated activation of dendritic cells

, 2015
As a potent immune regulator, heat shock protein 70 derived from Mycobacterium tuberculosis (Mtb Hsp70) has adjuvant effect and activates immune cells such as macrophages and dendritic cells (DCs). Although Toll-like receptors (TLRs) are known to involve
신성재
core   +1 more source

Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity

Frontiers in Immunology, 2020
Inhibitors that block the programmed cell death-1 (PD-1) pathway can potentiate endogenous antitumor immunity and have markedly improved cancer survival rates across a broad range of indications.
Shanling Shen, Gail Sckisel, Anupama Sahoo, Almin Lalani, Doug Den Otter, Josh Pearson, Jason DeVoss, Jay Cheng, Stephanie C. Casey, Ryan Case, Melissa Yang, Ray Low, Mark Daris, Bin Fan, Neeraj J. Agrawal, Khaled Ali   +15 more
doaj   +1 more source

Advances in IL–15–Based Cancer Immunotherapy and Divergent Immunological Effects of IL–2 and IL–15 Signaling via the Shared IL–2Rβγ Receptor

Frontiers in Immunology
Interleukin-15 (IL-15) has emerged as a central cytokine for next-generation cancer immunotherapy because of its unique ability to sustain the survival, proliferation, and cytotoxic function of memory CD8+ T cells and natural killer (NK) cells without ...
Huiquan Gao, Tao Ma, Qinqin Jiang, Lanfang Gao, Jinfang Li, Shubo Wang, Ziyong Liu, Zhixin Zhang, Gang Wu, Wenxin He, Fuxin Zhou   +10 more
doaj   +1 more source

Interleukin IL-1β stimulates revitalization of cartilage matrix in vitro with human nasal chondrocytes

Вестник трансплантологии и искусственных органов, 2020
Revitalization of decellularized or devitalized matrix scaffolds in tracheal tissue engineering typically involves seeding the autologous recipient cells or allogeneic cells under long-term cultivation.
D. S. Baranovsky, A. V. Lyundup, M. V. Balyasin, I. D. Klabukov, O. A. Krasilnikova, M. E. Krasheninnikov, V. D. Parshin   +6 more
doaj   +1 more source

Ischemic stroke and repair: current trends in research and tissue engineering treatments [PDF]

Regenerative Medicine Research, 2014
Stroke, the third leading cause of mortality, is usually associated with severe disabilities, high recurrence rate and other poor outcomes. Currently, there are no long-term effective treatments for stroke.
Wang Jian, Yang Wen, Xie Hongjian, Song Yu, Li Yongkui, Wang Lin   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source