Results 21 to 30 of about 5,332,469 (256)

Cytokine engineering for targeted cancer immunotherapy [PDF]

, 2021
Cytokines are key modulators of the immune responses and represent promising therapeutics for a variety of cancers. However, successful translation of cytokine-based therapy to the clinic is limited by, among others, severe toxicities and lack of ...
Tang, Li, Bonati, Lucia, Lucia Bonati, Li Tang   +3 more
core   +1 more source

Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects

Pharmaceutics, 2023
Anti-tumor properties of several cytokines have already been investigated in multiple experiments and clinical trials. However, those studies evidenced substantial toxicities, even at low cytokine doses, and the lack of tumor specificity.
Vladislav S. Rybchenko, Teimur K. Aliev, Anna A. Panina, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh   +4 more
doaj   +1 more source

Extraordinary effects of unnatural pairings

eLife, 2017
Engineered molecules based on human cytokines have potential uses in research and medicine.
Alejandro Villarino, John J O'Shea
doaj   +1 more source

Environmental and microbial factors influence affective and cognitive behavior in C57BL/6 sub-strains

Frontiers in Immunology, 2023
C57BL/6 mice are one of the most widely used inbred strains in biomedical research. Early separation of the breeding colony has led to the development of several sub-strains.
Nada Abdel Aziz, Nada Abdel Aziz, Nada Abdel Aziz, Inssaf Berkiks, Inssaf Berkiks, Paballo Mosala, Paballo Mosala, Tiroyaone M. Brombacher, Tiroyaone M. Brombacher, Frank Brombacher, Frank Brombacher   +10 more
doaj   +1 more source

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

eLife, 2017
Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine Kinase (RTK)-mediated trans-phosphorylation.
Ignacio Moraga, Jamie B Spangler, Juan L Mendoza, Milica Gakovic, Tom S Wehrman, Peter Krutzik, K Christopher Garcia   +6 more
doaj   +1 more source

Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells : implications for adoptive immunotherapy after allogeneic stem cell transplantation [PDF]

, 2010
Background: Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and has a poor prognosis. Here we assessed the capability of ex vivo expanded cytokine-induced killer cells to lyse both alveolar and embryonic rhabdomyosarcoma cell lines ...
H. Kreyenberg, Gerrit Weber, S. Kloss, Bader, Peter, Koscielniak, Ewa, A. Willasch, Selim Kuci, T. Klingebiel, E. Koscielniak, Laer, Dorothee von, Miriam Stais, Willasch, Andre Manfred, D. von Laer, Klingebiel, Thomas, Klöß, Stephan, Stais, Miriam, Kuçi, Selim, Peter Bader, Eva Rettinger, Thomas Klingebiel, B. Voss, Z. Kuci, Kreyenberg, Hermann, Stephan Klöss, G. Weber, Dorothee Von Laer, E. Rettinger, Zyrafete Kuci, Kuçi, Zyrafete, Rettinger, Eva, Bernhard Voss, M. Stais, P. Bader, Hermann Kreyenberg, Weber, Gerrit, Voß, Bernhard, Ewa Koscielniak, Andre Willasch, S. Kuci   +38 more
core   +1 more source

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

eLife, 2019
Cytokines activate signaling via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes.
Jonathan Martinez-Fabregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pohler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga   +12 more
doaj   +1 more source

COVID-19 cytokine storm: The anger of inflammation

, 2020
Patients with COVID-19 who require ICU admission might have the cytokine storm. It is a state of out-of-control release of a variety of inflammatory cytokines. The molecular mechanism of the cytokine storm has not been explored extensively yet.
Keshavarz, Mohsen, Farrokhi, Shokrollah, Nabipour, Iraj, Roozbeh, Jamshid, Mahmudpour, Mehdi   +4 more
core   +1 more source

Mapping Determinants of Cytokine Signaling via Protein Engineering

Frontiers in Immunology, 2018
Cytokines comprise a large family of secreted ligands that are critical for the regulation of immune homeostasis. Cytokines initiate signaling via dimerization or oligomerization of the cognate receptor subunits, triggering the activation of the Janus ...
Claire Gorby, Jonathan Martinez-Fabregas, Stephan Wilmes, Ignacio Moraga   +3 more
doaj   +1 more source

Nanoparticles and cytokine response

Frontiers in Bioengineering and Biotechnology, 2023
Synthetic nanoparticles (NPs) are non-viral equivalents of viral gene delivery systems that are actively explored to deliver a spectrum of nucleic acids for diverse range of therapies.
Mohammad Nasrullah, Daniel Nisakar Meenakshi Sundaram, Jillian Claerhout, Khanh Ha, Erkan Demirkaya, Hasan Uludag, Hasan Uludag, Hasan Uludag   +7 more
doaj   +1 more source