Results 1 to 10 of about 740,611 (277)

The role of circular RNAs in regulating cytokine signaling in cancer [PDF]

FEBS Open Bio
Dysregulation of cytokine signaling is central to the development and progression of cancer. Cytokines are not only involved in promoting cancer development but also regulate anti‐tumor immune responses.
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
doaj   +2 more sources

Single-cell RNA sequencing and AlphaFold 3 insights into cytokine signaling and its role in uveal melanoma [PDF]

Frontiers in Immunology
BackgroundUveal melanoma (UVM) is a form of eye cancer with a poor prognosis, particularly in metastatic patients. This study aimed to elucidate the cellular heterogeneity within UVM and identify prognostic biomarkers.MethodsWe performed single-cell RNA ...
Hongyan Sun, Cunzi Li, Zuhui Pu, Zuhui Pu, Ying Lu, Ying Lu, Zijing Wu, Zijing Wu, Lan Zhou, Lan Zhou, Hongzhan Lin, Yumo Wang, Tao Zi, Lisha Mou, Lisha Mou, Ming-ming Yang   +15 more
doaj   +2 more sources

Cytokine Signaling in Diabetic Neuropathy: A Key Player in Peripheral Nerve Damage [PDF]

Biomedicines
Diabetic peripheral neuropathy (DPN) is a debilitating complication of diabetes mellitus, characterized by progressive nerve damage driven by chronic hyperglycemia and systemic inflammation.
Zahra Nashtahosseini, Majid Eslami, Elham Paraandavaji, Alireza Haraj, Bahram Fadaee Dowlat, Ehsan Hosseinzadeh, Valentyn Oksenych, Ramtin Naderian   +7 more
doaj   +2 more sources

Suppressors of cytokine signaling 1 protein in a regenerative model of the Gekko japonicus spinal cord [PDF]

Journal of Integrative Neuroscience, 2021
Demyelination is one of the pathological outcomes that occur immediately following spinal cord injury. Protection of oligodendrocytes against death/apoptosis proves to be beneficial for the preservation of neurological functions.
Bingqiang He, Wenjuan Wang, Chunshuai Sun, Ting Yang, Hui Li, Xiaojun Chen, Hao Liang, Honghua Song, Yongjun Wang, Yingjie Wang   +9 more
doaj   +1 more source

Editorial: Cytokine signaling and innate host defense in modulation of viral infections and the viral evasion [PDF]

Frontiers in Cellular and Infection Microbiology
M. Victoria Delpino, Jorge Quarleri
doaj   +2 more sources

SUN-309 Cytokine Signaling by Thyronine and NAD in Colon and Pancreas - Case reports Highlighting Stem Cell Differentiation and Insulin Regulation [PDF]

J Endocr Soc
Timothy Bilash
europepmc   +3 more sources

IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation

Frontiers in Immunology, 2022
Regulation of innate immune responses is essential for maintenance of immune homeostasis and development of an appropriate immunity against microbial infection.
Françoise Vuillier, Françoise Vuillier, Zhi Li, Zhi Li, Iain Black, Iain Black, Melania Cruciani, Melania Cruciani, Erminia Rubino, Erminia Rubino, Frédérique Michel, Frédérique Michel, Sandra Pellegrini, Sandra Pellegrini   +13 more
doaj   +1 more source

Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21

Frontiers in Genetics, 2021
Ubiquitin-specific peptidase 18 (USP18) acts as gatekeeper of type I interferon (IFN) responses by binding to the IFN receptor subunit IFNAR2 and preventing activation of the downstream JAK/STAT pathway.
Erminia Rubino, Erminia Rubino, Melania Cruciani, Nicolas Tchitchek, Nicolas Tchitchek, Anna Le Tortorec, Antoine D. Rolland, Önay Veli, Leslie Vallet, Giulia Gaggi, Frédérique Michel, Nathalie Dejucq-Rainsford, Sandra Pellegrini   +12 more
doaj   +1 more source

Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment

Frontiers in Immunology, 2021
BackgroundInterferon beta (IFNβ) has been prescribed as a first-line disease-modifying therapy for relapsing-remitting multiple sclerosis (RRMS) for nearly three decades.
Priyanka Devi-Marulkar, Priyanka Devi-Marulkar, Carolina Moraes-Cabe, Carolina Moraes-Cabe, Pascal Campagne, Béatrice Corre, Béatrice Corre, Aida Meghraoui-Kheddar, Aida Meghraoui-Kheddar, Vincent Bondet, Alba Llibre, Darragh Duffy, Elisabeth Maillart, Caroline Papeix, Sandra Pellegrini, Sandra Pellegrini, Frédérique Michel, Frédérique Michel   +17 more
doaj   +1 more source

Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven Modulation of Regulatory Cytokines via the mTOR/GSK-3β Axis

Frontiers in Immunology, 2021
In human primary dendritic cells (DC) rapamycin—an autophagy inducer and protein synthesis inhibitor—overcomes the autophagy block induced by Mycobacterium tuberculosis (Mtb) and promotes a Th1 response via IL-12 secretion.
Marilena P. Etna, Martina Severa, Valerio Licursi, Manuela Pardini, Melania Cruciani, Fabiana Rizzo, Elena Giacomini, Gianfranco Macchia, Orazio Palumbo, Raffaella Stallone, Massimo Carella, Mark Livingstone, Rodolfo Negri, Sandra Pellegrini, Eliana M. Coccia   +14 more
doaj   +1 more source