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Suppressors of Cytokine Signaling and Hepatocellular Carcinoma. [PDF]
Cancers (Basel), 2022 Simple Summary Hepatocellular carcinoma (HCC) is a common malignancy worldwide. The HCC generally develops in the liver of patients already suffering from chronic liver disease.
Masuzaki R +9 more
europepmc +2 more sources
Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment [PDF]
Frontiers in Immunology, 2017 Suppressor of cytokine signaling (SOCS) proteins are major negative feedback regulators of cytokine signaling mediated by the Janus kinase (JAK)-signal transducer and activator of transcription signaling pathway. In particular, SOCS1 and SOCS3 are strong
Mengmeng Jiang +5 more
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Cytokine Signaling in Tumor Progression [PDF]
Immune Network, 2017 Cytokines are molecules that play critical roles in the regulation of a wide range of normal functions leading to cellular proliferation, differentiation and survival, as well as in specialized cellular functions enabling host resistance to pathogens.
Lee, Myungmi, Rhee, Inmoo
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OncoImmunology, 2017 The cytokine-induced SH2-containing protein CIS belongs to the suppressor of cytokine signaling (SOCS) protein family. Here, we show the critical role of CIS in suppressing natural killer (NK) cell control of tumor initiation and metastasis.
Eva M. Putz +9 more
doaj +2 more sources
Evolution of Cytokine Receptor Signaling [PDF]
The Journal of Immunology, 2016 Abstract Cytokines represent essential mediators of cell–cell communication with particularly important roles within the immune system. These secreted factors are produced in response to developmental and/or environmental cues and act via cognate cytokine receptors on target cells, stimulating specific intracellular signaling pathways to
Clifford Liongue +2 more
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Single-cell RNA sequencing and AlphaFold 3 insights into cytokine signaling and its role in uveal melanoma [PDF]
Frontiers in ImmunologyBackgroundUveal melanoma (UVM) is a form of eye cancer with a poor prognosis, particularly in metastatic patients. This study aimed to elucidate the cellular heterogeneity within UVM and identify prognostic biomarkers.MethodsWe performed single-cell RNA ...
Hongyan Sun +15 more
doaj +2 more sources
Three-Dimensional Gradients of Cytokine Signaling between T Cells.
PLoS Computational Biology, 2015 Immune responses are regulated by diffusible mediators, the cytokines, which act at sub-nanomolar concentrations. The spatial range of cytokine communication is a crucial, yet poorly understood, functional property. Both containment of cytokine action in
Kevin Thurley +3 more
doaj +2 more sources
The role of circular RNAs in regulating cytokine signaling in cancer [PDF]
FEBS Open BioDysregulation of cytokine signaling is central to the development and progression of cancer. Cytokines are not only involved in promoting cancer development but also regulate anti‐tumor immune responses.
Vandana Joshi +4 more
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Cytokine Signaling in Diabetic Neuropathy: A Key Player in Peripheral Nerve Damage [PDF]
BiomedicinesDiabetic peripheral neuropathy (DPN) is a debilitating complication of diabetes mellitus, characterized by progressive nerve damage driven by chronic hyperglycemia and systemic inflammation.
Zahra Nashtahosseini +7 more
doaj +2 more sources
eLife, 2017 Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza.
Łukasz Kedzierski +21 more
openalex +2 more sources