Results 21 to 30 of about 5,759,209 (333)
Structure of the IL-27 quaternary receptor signaling complex
eLife, 2022 Interleukin 27 (IL-27) is a heterodimeric cytokine that functions to constrain T cell-mediated inflammation and plays an important role in immune homeostasis.
Nathanael A Caveney +4 more
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Cytokine signaling convergence regulates the microglial state transition in Alzheimer’s disease
Cellular and Molecular Life Sciences, 2021 Genetic analyses have revealed the pivotal contribution of microglial dysfunctions to the pathogenesis of Alzheimer’s disease (AD). Along AD progression, the accumulation of danger-associated molecular patterns (DAMPs) including beta-amyloid and ...
S. Lau, A. Fu, N. Ip
semanticscholar +1 more source
Designing a Topical Nanoliposomal Formulation of Ruxolitinib Phosphate [PDF]
Pharmaceutical Sciences, 2023 Background: The JAK-STAT pathway has been revealed to play a crucial role in the dysregulation of immune responses in autoimmune skin disorders. Ruxolitinib, a selective inhibitor of JAK1 and JAK2, potently suppresses cytokine signaling.
Atefeh Naeimifar +5 more
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Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain
Pharmaceuticals, 2023 Hyperactive mutation V617F in the JAK2 regulatory pseudokinase domain (JH2) is prevalent in patients with myeloproliferative neoplasms. Here, we identified novel small molecules that target JH2 of JAK2 V617F and characterized binding via biochemical and ...
Anniina T. Virtanen +8 more
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Socs3b regulates the development and function of innate immune cells in zebrafish
Frontiers in Immunology, 2023 IntroductionSuppressor of cytokine signaling 3 (SOCS3) is a critical component of the negative feedback regulation that controls signaling by cytokines and other factors thereby ensuring that important processes such as hematopoiesis and inflammation ...
Mohamed L. Sobah +7 more
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Hematopoietic cytokine receptor signaling [PDF]
Oncogene, 2007 Hematopoiesis is the cumulative result of intricately regulated signaling pathways that are mediated by cytokines and their receptors. Proper culmination of these diverse pathways forms the basis for an orderly generation of different cell types. Recent studies conducted over the past 10-15 years have revealed that hematopoietic cytokine receptor ...
S J, Baker, S G, Rane, E P, Reddy
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Biotechnology & Biotechnological Equipment, 2021 Bone loss is caused by inflammation and is mediated by pro-inflammatory cytokines that control bone formation and bone resorption. The study aimed to determine the effect of secreted factors from human bone marrow-derived stromal cells (hBMSC) of no ...
Amer Mahmood* +3 more
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Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms
Experimental and Molecular Medicine, 2021 Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue injuries and is a bioindicator of multiple distinct types of cytokine storms.
Sujin Kang, T. Kishimoto
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Cytokine Signaling Exposed [PDF]
Structure, 2011 In this issue, Lupardus et al. (2011) provide images, obtained by electron microscopy, of a complete cytokine signaling complex, offering clues into the mechanism by which binding of cytokines to their cognate receptors triggers trans-phosphorylation and activation of Janus kinases.
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