Results 91 to 100 of about 1,697,286 (361)

Comparative Analysis of Genetically Engineered Immunodeficient Mouse Strains as Recipients for Human Myoblast Transplantation

Cell Transplantation, 2005
The development of an optimized animal model for the in vivo analysis of human muscle cells remains an important goal in the search of therapy for muscular dystrophy.
Suse D. Silva-Barbosa, Gillian S. Butler-Browne, James P. Di Santo, Vincent Mouly   +3 more
doaj   +1 more source

Schistosomiasis Burden and Its Association With Lower Measles Vaccine Responses in School Children From Rural Cameroon

Frontiers in Immunology, 2018
Background and Methods: Schistosomiasis is debilitating and reported to impair immune responsiveness of infected hosts. In Cameroon, mass drug administration (MDA) is used in schoolchildren to reduce transmission of S. haematobium and S. mansoni.
Justin Komguep Nono, Justin Komguep Nono, Justin Komguep Nono, Justin Komguep Nono, Severin Donald Kamdem, Severin Donald Kamdem, Severin Donald Kamdem, Palmer Masumbe Netongo, Smritee Dabee, Michael Schomaker, Alim Oumarou, Frank Brombacher, Frank Brombacher, Frank Brombacher, Frank Brombacher, Roger Moyou-Somo   +15 more
doaj   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Innovative Alkanediol-Based Eutectic Solvents for Extracting/Pre-Formulating Dermatologically Valuable Free Fatty Acids from Spirulina and Porphyridium Cakes

Marine Drugs
The growing demand for phycobiliproteins from microalgae generates a significant volume of by-products, such as extraction cakes. These cakes are enriched with products of interest for the cosmetics market, namely free fatty acids, particularly ...
Laura Wils, Mervé Yagmur, Nicolas Bellin, Myriam Phelippe, Alia Chevalley, Charles Bodet, Leslie Boudesocque-Delaye   +6 more
doaj   +1 more source

Measurement of Cytokines

Bio-Protocol, 2012
This protocol allows to measure the levels cytokines - such as VEGFs, CXCLs cytokines, PDGF or FGF - from fresh samples but also frozen tumors. The advantage of this method is to use very few micrograms of biological material and the protocol is carried ...
Renaud Grépin, Gilles Pagès
doaj   +1 more source

A computational high-throughput screening approach of iNKT-agonists: a novel tool to find optimized iNKT cell ligands [PDF]

, 2013
Depending on the environment and the activating glycolipids, iNKT cells are known to induce T-helper 1 and/or T-helper 2 cytokines. This highly versatile nature makes these innate-like cells very interesting targets for immunomodulation.
ASPESLAGH, SANDRINE, De Spiegeleer, Anton, Elewaut, Dirk, Stalmans, Sofie, Van Calenbergh, Serge, Van Den Noortgate, Nele, Vandekerckhove, Matthias, Venken, Koen, Wynendaele, Evelien   +8 more
core  

Network model of immune responses reveals key effectors to single and co-infection dynamics by a respiratory bacterium and a gastrointestinal helminth [PDF]

, 2012
Co-infections alter the host immune response but how the systemic and local processes at the site of infection interact is still unclear. The majority of studies on co-infections concentrate on one of the infecting species, an immune function or group of
A Graham, A Saadatpour, AJ Bancroft, AK Pathak, AK Pathak, AK Pathak, AL Graham, AP Boyd, Ashutosh K. Pathak, C Campbell, C Espinosa-Soto, C Lacroux, CA Behm, CA Blish, CA Figueiredo, CC Chen, CD Bourke, DL Abraham, DN Wolfe, EJ Pishko, ER Walsh, F Audebert, FD Finkelman, FE Cox, GB Harrison, GR Stewart, GS Kirimanjeswara, IM Cattadori, IM Cattadori, Isabella M. Cattadori, J Holmgren, J Thakar, J Thakar, J Thakar, JA Jackson, JD Turner, JE Allen, JG Fox, JS Fahel, JT Pesce, Juilee Thakar, L Glass, L Murphy, L Sanchez, Lisa Murphy, LJ Wang, M Chaves, MR Pilione, MT Brady, NG Henderson, NW Brattig, P Gueirard, P Matzinger, R Zhang, RK Grencis, RM Anthony, Rob J. De Boer, Réka Albert, S Bornholdt, S Cornell, S Li, S Mattoo, SM Assmann, SM Geiger, T Beyer, T Resende Co, TM Stock, V Haukisalmi, WI Khan, X Xu   +69 more
core   +3 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation

Cell Reports, 2019
Summary: Natural killer (NK) cells are unique players in innate immunity and, as such, an attractive target for immunotherapy. NK cells display immune memory properties in certain models, but the long-term status of NK cells following systemic ...
Orhan Rasid, Christine Chevalier, Tiphaine Marie-Noelle Camarasa, Catherine Fitting, Jean-Marc Cavaillon, Melanie Anne Hamon   +5 more
doaj