Results 261 to 270 of about 1,823,964 (347)

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Massive Hemorrhage in PCV Is Associated With Lower-Than-Normal VEGF Level and Dramatically Elevated Inflammatory Cytokine Levels in Aqueous Mingxuan. [PDF]

J Ophthalmol
Zhang M, Wang Y, Feng L, Zhang P, Li Y, Chen H.   +5 more
europepmc   +1 more source

Geometrically Tunable Scaffold‐Free Muscle Bioconstructs for Treating Volumetric Muscle Loss

Advanced Healthcare Materials, EarlyView.
Volumetric muscle loss is associated with traumatic muscle resulting in permanent functional impairment. Mold‐based, scaffold‐free, high‐density muscle tissue bioconstructs are developed in customizable geometric shapes and sizes. The transplanted rectangular solid‐shaped muscle bioconstructs improved muscle force recovery and tissue regeneration in ...
Bugra Ayan, Gaoxian Chen, Ishita Jain, Sha Chen, Gladys Chiang, Caroline Hu, Renato Reyes, Beu P. Oropeza, Ngan F. Huang   +8 more
wiley   +1 more source

Th17 cytokines regulate profibrotic cytokines release by human eosinophils

Allergy, Asthma & Clinical Immunology, 2012
Halwani Rabih, Al Muhsen Saleh, Al Jahdali Hamdan, Hamid Qutayba   +3 more
doaj   +1 more source

Investigating the causal relationship and mediating mechanisms between Clonal hematopoiesis and vitamin D levels: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Liang C, Li M, Sun Z.
europepmc   +1 more source

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash, Jacob Robins, J. Scott VanEpps, Minji Kim, Jouha Min   +4 more
wiley   +1 more source

Immune System and Hepatic Stellate Cells' Crosstalk in Liver Fibrosis: Pathways and Therapeutic Potential. [PDF]

J Immunol Res
Widowati W, Sabrina AHN, Sutendi AF, Zahiroh FH, Nurjamil AM, Wargasetia TL, Nainggolan IM, Azis R, Rismani E, Vosough M.   +9 more
europepmc   +1 more source

Determination of cytokine and growth factor levels to assess endothelial dysfunction in reproductive pathologies

S. V. Chepanov, Anastasia Sirotskaya, Д. И. Соколов, Olesya N. Bespalova, Vladimir Babakov, N. Yu. Rogovskaya, Ekaterina S. Orlova, S. А. Selkov   +7 more
openalex   +2 more sources

A Patient‐Specific 3D Printed Carotid Artery Model Integrating Vascular Structure, Flow, and Endothelium Responses

Advanced Healthcare Materials, EarlyView.
This study introduces the first miniaturized, patient‐specific carotid artery model created via 3D printing using GelMA with embedded vascular cells. Combining CFD, PIV, and flow perfusion, the model replicates anatomically dependent hemodynamics and cellular responses.
Jorge A. Catano, Louis Jun Ye Ong, Mingyang Yuan, Yunkun Qu, Jessica Benitez, Prasad KDV Yarlagadda, Yi‐Chin Toh, Zhiyong Li   +7 more
wiley   +1 more source