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Current Opinion in Immunology, 1989
Cytokines manifest multiple biological activities in different target cells, and many cytokines are produced by a variety of cell types in response to different stimuli. Furthermore, the expression of a given cytokine gene is invariably influenced by other cytokines, forming a network of ‘cytokine cascades’.
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Cytokines manifest multiple biological activities in different target cells, and many cytokines are produced by a variety of cell types in response to different stimuli. Furthermore, the expression of a given cytokine gene is invariably influenced by other cytokines, forming a network of ‘cytokine cascades’.
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Cytokine Drizzle: The Rationale for Abandoning “Cytokine Storm”
Journal of the American College of Surgeons, 2021ABSTRACT Background: “Cytokine storm” has been used to implicate increased cytokine levels in the pathogenesis of serious clinical conditions. Similarities with Severe Acute Respiratory Syndrome Coronoavirus-2 (SARS CoV-2) and the 2012 Middle Eastern Respiratory Syndrome led early investigators to suspect a “cytokine ...
Allan E, Stolarski +3 more
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Cytokines and natural regulators of cytokines
Immunology Letters, 1994Cytokines are polypeptide or glycopeptide signalling molecules with molecular weights from 5 to 70,000 Daltons (Table 1). They act at extremely low concentrations (picomolar and femtomolar levels) as essential mediators of infectious and immunoinflammatory reactions.
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Inhaled cytokines and cytokine antagonists
Advanced Drug Delivery Reviews, 2006Cytokine and cytokine antagonist have provided novel and effective therapies for many human diseases. A number of approved cytokines including the interferons (alpha, beta and gamma), interleukin-2 (IL-2), granulocyte macrophage colony stimulating factor (GM-CSF) as well as novel cytokine antagonists have been administered by the pulmonary route for ...
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Cytokines and anti-cytokines as therapeutics — An update
European Journal of Pharmacology, 2008Cytokines which comprise of a family of proteins--interleukins, lymphokines, monokines, interferons, and chemokines, are important components of the immune system. They act in concert with specific cytokine inhibitors and soluble cytokine receptors to regulate the human immune response.
Vandana, Tayal, Bhupinder Singh, Kalra
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Cytokines in Cytokine Storm Syndrome
2019As the eponymous mediators of the cytokine storm syndrome, cytokines are a pleomorphic and diverse set of soluble molecules that activate or suppress immune functions in a wide variety of ways. The relevant cytokines for each CSS are likely a result of differing combinations of environmental triggers and host susceptibilities.
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Journal of Allergy and Clinical Immunology, 1996
Summary Cytokines that are important in the pathophysiology of allergic disorders are summarized on Table V. The IgE isotype switch results from the activities of IL-4 and IL-13 and is inhibited by IFN-ggg and TGF-β. IL-2, IL-5, and IL-6 synergize with IL-4 and IL-13 to enhance IgE secretion.
L, Borish, L J, Rosenwasser
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Summary Cytokines that are important in the pathophysiology of allergic disorders are summarized on Table V. The IgE isotype switch results from the activities of IL-4 and IL-13 and is inhibited by IFN-ggg and TGF-β. IL-2, IL-5, and IL-6 synergize with IL-4 and IL-13 to enhance IgE secretion.
L, Borish, L J, Rosenwasser
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Cytokines and Cytokine-Specific Therapy in Asthma
2012Asthma is increasing in prevalence worldwide. It is characterized by typical symptoms and variable airway obstruction punctuated with episodes of worsening symptoms known as exacerbations. Underlying this clinical expression of disease is airway inflammation and remodeling.
Dhananjay, Desai +1 more
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Cytokine and anti-cytokine therapy for asthma
Current Allergy and Asthma Reports, 2006Cytokines play a critical role in the pathogenesis of asthma. Asthma resolution may depend on the correction of dysregulated cytokine expression, which is a characteristic feature of this chronic inflammatory disease. It is, therefore, not surprising that attempts have been made to either block cytokines present at elevated levels or to substitute ...
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Cytokines, Cytokine Receptors and Cytokine Antibodies: Clinical Implications
1997Cytokines are produced by almost any cell and function as important mediators of cell activation, differentiation and proliferation. These diffusibile glycoproteins appear to participate in the mediation of inflammatory as well as immune reactions, and some peptides may even influence tumor growth.
E. Berti +3 more
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