Results 151 to 160 of about 3,428 (189)
Genotoxic Escherichia coli Strains Encoding Colibactin, Cytolethal Distending Toxin, and Cytotoxic Necrotizing Factor in Laboratory Rats. [PDF]
Comp Med, 2019 Kurnick SA +5 more
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A novel mode of translocation for cytolethal distending toxin
Biochimica Et Biophysica Acta - Molecular Cell Research, 2009 Thermal instability in the toxin catalytic subunit may be a common property of toxins that exit the endoplasmic reticulum (ER) by exploiting the mechanism of ER-associated degradation (ERAD). The Haemophilus ducreyi cytolethal distending toxin (HdCDT) does not utilize ERAD to exit the ER, so we predicted the structural properties of its catalytic ...
Suren A Tatulian +2 more
exaly +6 more sources
Cytolethal Distending Toxin Damages the Oral Epithelium of Gingival Explants [PDF]
Journal of Dental Research, 2011 The cytolethal distending toxin (Cdt), expressed by the periodontal pathogen Aggregatibacter actinomycetemcomitans, inhibits the proliferation of cultured epithelial cells by arresting the cell cycle. The gingival epithelium is an early line of defense against microbial assault.
M Haris, J M Dirienzo
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Expression and activity of the cytolethal distending toxin of Helicobacter hepaticus
Biochemical and Biophysical Research Communications, 2004Helicobacter hepaticus, a causal agent of hepatocarcinoma in mice, exhibits a cytolethal distending toxin activity. The three subunits of this holotoxin, CdtA, CdtB, and CdtC, and three CdtB mutants were produced as recombinant histidine-tagged proteins by using an in vitro cell-free protein expression system. We found that the presence of the three H.
Sandra Claret +2 more
exaly +3 more sources
The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin
EcoSal Plus, 2016While the DNA damage induced by ionizing radiation and by many chemical compounds and drugs is well characterized, the genotoxic insults inflicted by bacteria are only scarcely documented. However, accumulating evidence indicates that we are exposed to bacterial genotoxins.
Taieb, Frederic +3 more
openaire +5 more sources
The cytolethal distending toxin family
Trends in Microbiology, 1999Cytolethal distending toxins are produced by a small but diverse group of bacterial pathogens. This newly discovered toxin family can cause a variety of mammalian cells to become irreversibly blocked in the G2 phase of the cell cycle. How this novel effect is accomplished is unknown but the study of these fascinating toxins promises to reveal new ...
C L, Pickett, C A, Whitehouse
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Dynamics and assembly of the cytolethal distending toxin
Proteins: Structure, Function, and Bioinformatics, 2006AbstractThe cytolethal distending toxin (CDT) is a widespread bacterial toxin that consists of an active subunit CdtB with nuclease activity and two ricin‐like lectin domains, CdtA and CdtC, that are involved in the delivery of CdtB into the host cell.
Xin, Hu, C Erec, Stebbins
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The Contribution of Cytolethal Distending Toxin to Bacterial Pathogenesis
Critical Reviews in Microbiology, 2006Cytolethal distending toxin (CDT) is a bacterial toxin that initiates a eukaryotic cell cycle block at the G2 stage prior to mitosis. CDT is produced by a number of bacterial pathogens including: Campylobacter species, Escherichia coli, Salmonella enterica serovar Typhi, Shigella dystenteriae, enterohepatic Helicobacter species, Actinobacillus ...
James L, Smith, Darrell O, Bayles
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2004
The cytolethal distending toxins (CDTs) constitute the most recently discovered family of bacterial protein toxins. CDTs are unique among bacterial toxins as they have the ability to induce DNA double strand breaks (DSBs) in both proliferating and nonproliferating cells, thereby causing irreversible cell cycle arrest or death of the target cells.
M, Thelestam, T, Frisan
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The cytolethal distending toxins (CDTs) constitute the most recently discovered family of bacterial protein toxins. CDTs are unique among bacterial toxins as they have the ability to induce DNA double strand breaks (DSBs) in both proliferating and nonproliferating cells, thereby causing irreversible cell cycle arrest or death of the target cells.
M, Thelestam, T, Frisan
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Cytolethal Distending Toxin: A Bacterial Bullet Targeted to Nucleus
Journal of Biochemistry, 2004Cytolethal distending toxin (Cdt) is a newly added member of bacterial protein toxins that hijack the control system of eukaryotic cells. Cdts are produced by several pathogenic bacteria causing chronic infectious diseases. They are composed of three subunits, CdtA, CdtB and CdtC, which together form a ternary complex. CdtB is the active component, and
Ohara, M, Oswald, Eric, Sugai, M
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