Results 161 to 170 of about 3,428 (189)

Acid-induced disassembly of the Haemophilus ducreyi cytolethal distending toxin

Biochemical and Biophysical Research Communications, 2022
The cytolethal distending toxins (CDTs) produced by many Gram-negative pathogens are tripartite genotoxins with a single catalytic subunit (CdtB) and two cell-binding subunits (CdtA + CdtC). CDT moves by vesicle carriers from the cell surface to the endosomes and through the Golgi apparatus en route to the endoplasmic reticulum (ER).
G. Robb Huhn, Celine Sparkes, Isabel Silva, Carla Reyes, Gisselle Perez, Fatema Khondker, Teriana Jones, Ashley Fragoso, Paula Contreras, Michelle Alvarez, Maria C. Zabala-Rodriguez, Suren A. Tatulian, Ken Teter   +12 more
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Comparative structure–function analysis of cytolethal distending toxins

Proteins: Structure, Function, and Bioinformatics, 2005
AbstractCytolethal distending toxins (CDTs) constitute a family of bacterial proteins that enter eukaryotic cells with genotoxic activity leading to cell cycle arrest and apoptosis. CDTs are widespread, having been found in a variety of Gram‐negative pathogens with a broad tissue tropism.
Xin, Hu, Dragana, Nesic, C Erec, Stebbins   +2 more
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Mechanism of internalization of the cytolethal distending toxin of Actinobacillus actinomycetemcomitans

Microbiology, 2005
Cytolethal distending toxin (CDT), which is encoded by three genes,cdtA,cdtBandcdtC, is now recognized to have a growing list of biological actions, including inhibition of cell cycle progression, promotion of apoptosis and stimulation of cytokine secretion. It appears that internalization of CDT is essential, at least for cell cycle blockade.
Sumio, Akifusa, Wendy, Heywood, Sean P, Nair, Gudrun, Stenbeck, Brian, Henderson   +4 more
openaire   +2 more sources

[Cytolethal distending toxins].

Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne, 2015
Cytolethal distending toxins (CDT) are intracellularly acting proteins which interfere with the eukaryotic cell cycle. They are produced by Gram-negative bacteria with affinity to mucocutaneous surfaces and could play a role in the pathogenesis of various mammalian diseases.
K, Curová, M, Kmeťová, L, Siegfried
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Cytolethal Distending Toxin

2014
This chapter examines the molecular biology and biochemistry of cytolethal distending toxin (CDT) and its molecular mode of action. Transcript analysis of the Haemophilus ducreyi cdt gene cluster (Hd-cdtABC) indicated that the cdt genes are organized in an operon. The cdtABC operon encodes three CDT polypeptides, CdtA, CdtB, and CdtC.
openaire   +1 more source

Cytolethal distending toxin of Actinobacillus actinomycetemcomitans

Journal of Periodontal Research, 2002
The cytolethal distending toxin (Cdt) of Actinobacillus actinomycetemcomitans, a periodontal pathogen, is a newly described cytotoxin with immunosuppressive properties, capable of causing cell cycle arrest of lymphocytes. The objectives of this study were to investigate the occurrence of A. actinomycetemcomitans with the cdt genotype in the subgingival
Tan, K.S., Song, K.-P., Ong, G.
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Cytolethal Distending Toxin in Avian and Human Isolates ofHelicobacter pullorum

The Journal of Infectious Diseases, 2000
Helicobacter pullorum has been isolated from the feces and livers of poultry and is associated with human gastroenteritis. Discrimination of this organism from other enterohepatic Helicobacter species and Campylobacter species has proven difficult. H. pullorum from both avian and human clinical sources has DNA sequence homology and cytotoxic activity ...
V B, Young, C C, Chien, K A, Knox, N S, Taylor, D B, Schauer, J G, Fox   +5 more
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A new mode of action for the cytolethal distending toxin

2013
The Cytolethal Distending Toxin (CDT) is a virulence factor produced by many pathogenic bacteria like E. coli, H. hepaticus, H. ducreyi etc. The CDT Production allows bacteria to persistently colonize the body, evade the immune system, induce inflammation and trigger genetic instability. In fact, CDT induces DNA double-stranded breaks (DSB), leading to
Bezine, Elisabeth, Fedor, Yoann, Vignard, Julien, Boutet-Robinet, Elisa, Salles, Bernard, Mirey, Gladys   +5 more
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Genotoxicity and repair: the cytolethal distending toxin model

2013
The Cytolethal Distending Toxin (CDT) is a virulence factor produced by many pathogenic bacteria (Escherichia coli, Helicobacter hepaticus ...) colonizing the oral cavity, the gastrointestinal tract, the liver etc. The presence in the gut of genotoxin producing bacteria, such as E.
Bezine, Elisabeth, Fedor, Yoann, Vignard, Julien, Boutet-Robinet, Elisa, Salles, Bernard, Mirey, Gladys   +5 more
openaire   +1 more source

[Expression of recombinant cytolethal distending toxin of Actinobacillus actinomycetemcomitans].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 2014
To examine the expression of recombinant cytolethal distending toxin (CDT) produced by Actinobacillus actinomycetemcomitans (Aa).CDT encoding gene cdtABC was amplified by PCR. Through TA clone and restriction endonuclease digestion, gene cdtABC and vector pQE60 were ligated to form pQE60-cdtABC expression system which transformed into competent cells ...
Shu, Meng, He, Yang, Lei, Zhao, Ya-Fei, Wu   +3 more
openaire   +1 more source