Results 61 to 70 of about 206,338 (244)

Immunosenescence and Cytomegalovirus: where do we stand after a decade? [PDF]

, 2010
Since Looney at al. published their seminal paper a decade ago it has become clear that many of the differences in T cell immunological parameters observed between young and old people are related to the age-associated increasing prevalence of infection ...
Grubeck-Loebenstein, B, Pawelec, Graham, Sven D Koch, Pawelec, G, Maier, Andrea B., Akbar, A, S D Koch (16139375), Beverly, P, Strindhall, J, A B Maier (13318254), Jahn, Gerhard, Kern, F, Samson, S, Griffiths, Paul, Caruso Calogero, K Hamprecht (16139369), Beatrix Grubeck-Loebenstein, Caruso, C, Samson, Sandrine, Moss, Paul; id_orcid, A Akbar (12141924), M Wills (13757002), A Larbi (16139378), Arne Akbar, Strindhall, Jan, Tamas Fülöp, Fülöp Tamas, Willis, Mark, Trannoy, Emanuelle, E Derhovanessian (16139360), D Macallan (16139381), Maier, AB, Akbar,A, Wills, M., Koch Sven D, Moss, P, Larbi,A, Derhovanessian, Evelyna, Trannoy Emanuelle, G Jahn (16139372), Macallan,D, Derhovanessian, E, Klaus Hamprecht, Kern, Florian, Hamprecht Klaus, Beverley,P, Trannoy, E, Larbi Anis, Jahn, G, Samson Sandrine, Graham Pawelec, Macallan, D, Hamprecht,K, Moss,P, Strindhall, Jan,, Beverley, P, Griffiths Paul, Hamprecht, K, Larbi, A, Paul Moss, Maier, Andrea B, Wills, Mark, Maier Andrea B, Macallan, Derek, Grubeck-Loebenstein, Beatrix, Sandrine Samson, Emanuelle Trannoy, Peter Beverley, Kern,F, Jahn Gerhard, Anis Larbi, P Beverley (16139354), Florian Kern, Kern Florian, Gerhard Jahn, Wills, M, Fülöp, Tamas, Koch, SD, Wills Mark, Moss, Paul, Beverley, Peter, Jan Strindhall, Derhovanessian Evelyna, Grubeck-Loebenstein Beatrix, Maier, Andrea B.; id_orcid, Koch, Sven D., Akbar, Arne, Strindhall Jan, S Samson (16139384), T Fulop (16139363), Derek Macallan, Fülöp, T, Mark Wills, B Grubeck-Loebenstein (16139366), P Griffiths (7757690), Evelyna Derhovanessian, Koch, Sven D, Grubeck Loebenstein, B, C Caruso (16139357), Andrea B Maier, E Trannoy (16139390), G Pawelec (16139351), P Moss (7787393), Larbi, Anis, Calogero Caruso, Pawelec Graham, Akbar Arne, Beverley Peter, Paul Griffiths, Moss Paul, Florian Kern (4461943), J Strindhall (16139387), Griffiths, P, Macallan Derek, Caruso, Calogero, Hamprecht, Klaus   +115 more
core   +3 more sources

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source

Human cytomegalovirus productively infects primary differentiated macrophages [PDF]

, 1991
Monocytes are one of the predominant cell types in the peripheral blood that are infected by human cytomegalovirus (HCMV). Although virus can be detected in these cells in vivo, HCMV replication in cultured monocytes has been unsuccessful. In this study,
Schrier, R, Wiley, C, Nelson, J A, Ibanez, C E, Ghazal, P   +4 more
core  

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Initial intravitreal injection of high-dose ganciclovir for cytomegalovirus retinitis in HIV-negative patients

BMC Ophthalmology, 2018
Background The purpose of this study is to examine the clinical outcomes achieved by using initial high-dose intravitreal ganciclovir injections to treat cytomegalovirus retinitis in patients without human immunodeficiency virus (HIV) infection.
Zhuyun Qian, Haili Li, Yong Tao, Wensheng Li   +3 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

The 89,000-Mr murine cytomegalovirus immediate-early protein stimulates c-fos expression and cellular DNA synthesis [PDF]

, 1988
The immediate-early (IE) genes of murine cytomegalovirus (MCMV) are expressed in the absence of prior viral protein synthesis and regulate the transcription of MCMV early genes. The effect of MCMV IE genes on growth induction was studied.
Pepperkok, Rainer, Koszinowski, Ulrich H., Schickedanz, Jörg, Klein, Rüdiger, Philipson, Lennart, Ansorge, Wilhelm   +5 more
core   +2 more sources

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Cytomegalovirus infection in patients attending a tertiary care hospital – single center experience

Iranian Journal of Microbiology
Background and Objectives: Human cytomegalovirus infection poses an important public health issue. This issue in India has not received enough attention.
Bashir Ahmad Fomda, Munaza Aman, Sanam Wani, Irfan ul Haq, Uksim Qadri, Insha Altaf, Sheikh Imtiyaz, Naseer A Bhat   +7 more
doaj   +1 more source