Results 11 to 20 of about 299,119 (223)

Molecular mechanisms of the interhead coordination by interhead tension in cytoplasmic dyneins. [PDF]

Proc Natl Acad Sci U S A, 2018
Significance Cell physiology strongly depends on motor proteins to transport and regulate the intracellular distributions of key materials and organelles.
Wang Q, Jana B, Diehl MR, Cheung MS, Kolomeisky AB, Onuchic JN.   +5 more
europepmc   +4 more sources

Cytoplasmic factories for axonemal dynein assembly. [PDF]

Journal of Cell Science, 2021
Axonemal dyneins power the beating of motile cilia and flagella. These massive multimeric motor complexes are assembled in the cytoplasm, and subsequently trafficked to cilia and incorporated into the axonemal superstructure. Numerous cytoplasmic factors
S. King
semanticscholar   +3 more sources

Cytoplasmic dynein nomenclature [PDF]

The Journal of Cell Biology, 2005
A variety of names has been used in the literature for the subunits of cytoplasmic dynein complexes. Thus, there is a strong need for a more definitive consensus statement on nomenclature.
K. Pfister, Elizabeth M.C. Fisher, Ian R. Gibbons, Thomas S. Hays, E. Holzbaur, J. R. McIntosh, Mary E. Porter, T. Schroer, Kevin T. Vaughan, G. Witman, S. King, Richard B. Vallee   +11 more
semanticscholar   +4 more sources

Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins

Nature, 2008
Cilia and flagella are highly conserved organelles that have diverse roles in cell motility and sensing extracellular signals. Motility defects in cilia and flagella often result in primary ciliary dyskinesia.
H. Omran, D. Kobayashi, H. Olbrich, Tatsuya Tsukahara, N. Loges, H. Hagiwara, Qi Zhang, Gerard Leblond, E. O'Toole, C. Hara, H. Mizuno, H. Kawano, M. Fliegauf, T. Yagi, S. Koshida, A. Miyawaki, H. Zentgraf, H. Seithe, R. Reinhardt, Yoshinori Watanabe, R. Kamiya, D. Mitchell, H. Takeda   +22 more
semanticscholar   +3 more sources

Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein. [PDF]

Cell Chemical Biology, 2018
Aberrant hedgehog (Hh) signaling contributes to the pathogenesis of multiple cancers. Available inhibitors target Smoothened (Smo), which can acquire mutations causing drug resistance. Thus, compounds that inhibit Hh signaling downstream of Smo are urgently needed. We identified dynarrestin, a novel inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin
S. Höing, T. Yeh, M. Baumann, N. E. Martinez, Peter Habenberger, L. Kremer, H. Drexler, Philipp Küchler, P. Reinhardt, A. Choidas, Mia-Lisa Zischinsky, Gunther Zischinsky, S. Nandini, Aaron P. Ledray, Stephanie A. Ketcham, L. Reinhardt, Masin Abo-Rady, Michael Glatza, S. J. King, P. Nussbaumer, Slava Ziegler, B. Klebl, T. Schroer, H. Schöler, H. Waldmann, J. Sterneckert   +25 more
semanticscholar   +5 more sources

X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3 [PDF]

Nature Communications, 2016
By moving essential body fluids and molecules, motile cilia and flagella govern respiratory mucociliary clearance, laterality determination and the transport of gametes and cerebrospinal fluid.
Al-Turki, Saeed, Allan, Daly, Amselem, Serge, Anderson, Carl, Antonarakis, Stylianos E., Antony, Dinu, Armengot, Miguel, Aurora, Paul, Barroso, Inês, Bartoloni, Lucia, Beales, Philip L., Bentham, Jamie, Bevillard, Jeremy, Bhattacharya, Shoumo, Blouin, Jean-Louis, Boustred, Christopher, Bush, Andrew, Cahill, Thomas, Carss, Keren, Chantot, Sandra, Chatterjee, Krishna, Chung, Eddie M. K., Cirak, Sebahattin, Copin, Bruno, Cosgrove, Catherine, Cullup, Thomas, Dixon, Mellisa, Duquesnoy, Philippe, Durbin, Richard, Dyer, Laura, Emes, Richard D., Escudier, Estelle, Fassad, Mahmoud R., Fitzpatrick, David, Floyd, Jamie, Foley, A. Reghan, Franklin, Chris, Futema, Marta, Garin, Antoine, Gehrig, Corinne, Goldenberg, Alice, Guipponi, Michel, Hayward, Jane, Hogg, Claire, Humphries, Steve E., Hurles, Matt, Jeanson, Ludovic, Jenkins, Lucy, Kiviluoto, Santeri, Legendre, Marie, Loebinger, Michael R., McCarthy, Shane, Mitchison, Hannah M., Muddyman, Dawn, Muntoni, Francesco, Munye, Mustafa M., Olcese, Chiara, Onoufriadis, Alexandros, Papon, Jean- François, Parker, Victoria, Patel, Mitali P., Payne, Felicity, Pin, Isabelle, Plagnol, Vincent, Raymond, Lucy, Savage, David B., Scambler, Peter J., Schmidts, Miriam, Semple, Robert, Serra, Eva, Shoemark, Amelia, Stalker, Jim, Sun, Zhaoxia, Tamalet, Aline, Thauvin-Robinet, Christel, Thomas, Lucie, van Kogelenberg, Margriet, Vaughan, Cara K., Vera, Gabriella, Vijayarangakannan, Parthiban, Walter, Klaudia, Williams, Hywel J., Wilson, Robert   +82 more
core   +10 more sources

Identification of the t Complex–encoded Cytoplasmic Dynein Light Chain Tctex1 in Inner Arm I1 Supports the Involvement of Flagellar Dyneins in Meiotic Drive

Journal of Cell Biology, 1998
The cytoplasmic dynein light chain Tctex1 is a candidate for one of the distorter products involved in the non-Mendelian transmission of mouse t haplotypes.
A. Harrison, P. Olds‐Clarke, S. King
semanticscholar   +3 more sources

Structure of human cytoplasmic dynein-2 primed for its powerstroke

Nature, 2014
Members of the dynein family, consisting of cytoplasmic and axonemal isoforms, are motors that move towards the minus ends of microtubules. Cytoplasmic dynein-1 (dynein-1) plays roles in mitosis and cellular cargo transport, and is implicated in viral ...
H. Schmidt, Ruta Zalyte, L. Urnavicius, A. Carter   +3 more
semanticscholar   +3 more sources

Dyneins Across Eukaryotes: A Comparative Genomic Analysis

Traffic, 2007
Dyneins are large minus‐end‐directed microtubule motors. Each dynein contains at least one dynein heavy chain (DHC) and a variable number of intermediate chains (IC), light intermediate chains (LIC) and light chains (LC).
B. Wickstead, K. Gull
semanticscholar   +3 more sources

The DHC1b (DHC2) Isoform of Cytoplasmic Dynein Is Required for Flagellar Assembly

Journal of Cell Biology, 1999
Dyneins are microtubule-based molecular motors involved in many different types of cell movement. Most dynein heavy chains (DHCs) clearly group into cytoplasmic or axonemal isoforms. However, DHC1b has been enigmatic. To learn more about this isoform, we
G. Pazour, B. L. Dickert, G. Witman
semanticscholar   +3 more sources