Results 31 to 40 of about 299,119 (223)

Regulators of the cytoplasmic dynein motor [PDF]

Nature Reviews Molecular Cell Biology, 2009
Eukaryotic cells use cytoskeletal motor proteins to transport many different intracellular cargos. Numerous kinesins and myosins have evolved to cope with the various transport needs that have arisen during eukaryotic evolution. Surprisingly, a single cytoplasmic dynein (a minus end-directed microtubule motor) carries out similarly diverse transport ...
Julia R, Kardon, Ronald D, Vale
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Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule

eLife, 2019
Dyneins are motor proteins responsible for transport in the cytoplasm and the beating of axonemes in cilia and flagella. They bind and release microtubules via a compact microtubule-binding domain (MTBD) at the end of a coiled-coil stalk.
Samuel E Lacey, Shaoda He, Sjors HW Scheres, Andrew P Carter   +3 more
doaj   +1 more source

The IDA3 adapter, required for intraflagellar transport of I1 dynein, is regulated by ciliary length [PDF]

, 2018
Axonemal dyneins, including inner dynein arm I1, assemble in the cytoplasm prior to transport into cilia by intraflagellar transport (IFT). How I1 dynein interacts with IFT is not understood.
Alford, Lea M, Dutcher, Susan K, Fu, Gang, Gokhale, Avanti, Hunter, Emily L, Hwang, Juyeon, Kamiya, Ritsu, Lechtreck, Karl, Lewis, Brian, Lin, Huawen, Nicastro, Daniela, Sale, Winfield S, Wirschell, Maureen, Yamamoto, Ryosuke, Yang, Fan   +14 more
core   +2 more sources

Cytoplasmic Dynein Promotes HIV-1 Uncoating [PDF]

Viruses, 2014
Retroviral capsid (CA) cores undergo uncoating during their retrograde transport (toward the nucleus), and/or after reaching the nuclear membrane. However, whether HIV-1 CA core uncoating is dependent upon its transport is not understood. There is some evidence that HIV-1 cores retrograde transport involves cytoplasmic dynein complexes translocating on
Pawlica, Paulina, Berthoux, Lionel
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A brief introduction to the model microswimmer {\it Chlamydomonas reinhardtii} [PDF]

, 2016
The unicellular biflagellate green alga {\it Chlamydomonas reinhardtii} has been an important model system in biology for decades, and in recent years it has started to attract growing attention also within the biophysics community.
Contino, Matteo, Jeanneret, Raphaël, Polin, Marco   +2 more
core   +2 more sources

CNS myelination requires cytoplasmic dynein function [PDF]

Developmental Dynamics, 2015
Background: Cytoplasmic dynein provides the main motor force for minus‐end‐directed transport of cargo on microtubules. Within the vertebrate central nervous system (CNS), proliferation, neuronal migration, and retrograde axon transport are among the cellular functions known to require dynein.
Michele L, Yang, Jimann, Shin, Christina A, Kearns, Melissa M, Langworthy, Heather, Snell, Macie B, Walker, Bruce, Appel   +6 more
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The Versatile Molecular Complex Component LC8 Promotes Several Distinct Steps of Flagellar Assembly [PDF]

, 2012
LC8 is present in various molecular complexes. However, its role in these complexes remains unclear. We discovered that although LC8 is a subunit of the radial spoke (RS) complex in Chlamydomonas flagella, it was undetectable in the RS precursor that is ...
Anjali Gupta, Barbar, Bergen, Bloch, Dennis R. Diener, DiBella, Diener, Diener, Dymek, Dymek, Espindola, Fejtova, Gaillard, Hall, Harris, Heuser, Huang, Jaffrey, Jivan, Joel L. Rosenbaum, Johnson, Kamiya, Kindle, King, LeDizet, Liang, Lightcap, Lin, Lo, Lo, Luo, Naisbitt, Navarro-Lérida, Nicastro, Patel-King, Pazour, Pazour, Pfister, Pigino, Pinfen Yang, Piperno, Piperno, Porter, Priyanka Sivadas, Puthalakath, Qin, Rodríguez-Crespo, Rompolas, Sakato, Segal, Stelter, Summers, Tan, Warner, Wei, Williams, Wirschell, Yang, Yang, Yang, Yang, Yang   +61 more
core   +2 more sources

Mechanism and Regulation of Cytoplasmic Dynein [PDF]

Annual Review of Cell and Developmental Biology, 2015
Until recently, dynein was the least understood of the cytoskeletal motors. However, a wealth of new structural, mechanistic, and cell biological data is shedding light on how this complicated minus-end-directed, microtubule-based motor works. Cytoplasmic dynein-1 performs a wide array of functions in most eukaryotes, both in interphase, in which it ...
Michael A, Cianfrocco, Morgan E, DeSantis, Andres E, Leschziner, Samara L, Reck-Peterson   +3 more
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Kinesin and dynein use distinct mechanisms to bypass obstacles

eLife, 2019
Kinesin-1 and cytoplasmic dynein are microtubule (MT) motors that transport intracellular cargoes. It remains unclear how these motors move along MTs densely coated with obstacles of various sizes in the cytoplasm.
Luke S Ferro, Sinan Can, Meghan A Turner, Mohamed M ElShenawy, Ahmet Yildiz   +4 more
doaj   +1 more source

Subunit organization in cytoplasmic dynein subcomplexes [PDF]

Protein Science, 2002
AbstractBecause cytoplasmic dynein plays numerous critical roles in eukaryotic cells, determining the subunit composition and the organization and functions of the subunits within dynein are important goals. This has been difficult partly because of accessory polypeptide heterogeneity of dynein populations.
Stephen J, King, Myriam, Bonilla, Michael E, Rodgers, Trina A, Schroer   +3 more
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