Results 1 to 10 of about 600,505 (317)
Multiple Poliovirus Proteins Repress Cytoplasmic RNA Granules [PDF]
Viruses, 2015 We have previously shown that poliovirus (PV) infection induces stress granule (SG) formation early in infection and then inhibits the formation of SG and disperses processing bodies (PBs) by the mid-phase of infection.
Jonathan D. Dougherty +2 more
doaj +4 more sources
Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules [PDF]
Cell, 2021 Receptor tyrosine kinase (RTK)-mediated activation of downstream effector pathways such as the RAS GTPase/MAP kinase (MAPK) signaling cascade is thought to occur exclusively from lipid membrane compartments in mammalian cells. Here, we uncover a membraneless, protein granule-based subcellular structure that can organize RTK/RAS/MAPK signaling in cancer.
Tulpule, Asmin +19 more
semanticscholar +5 more sources
Two Arabidopsis late pollen transcripts are detected in cytoplasmic granules. [PDF]
Plant Direct, 2017 Many of mRNAs synthesized during pollen development are translated after germination, and we hypothesize that they are stored in cytoplasmic granules. We analyzed the cellular localization of the SKS14 and AT59 Arabidopsis mRNAs, which are orthologues of
Scarpin MR +5 more
europepmc +2 more sources
Cytoplasmic RNA Granules in Somatic Maintenance [PDF]
Gerontology, 2018 Cytoplasmic RNA granules represent subcellular compartments that are enriched in protein-bound RNA species. RNA granules are produced by evolutionary divergent eukaryotes, including yeast, mammals, and plants. The functions of cytoplasmic RNA granules differ widely. They are dictated by the cell type and physiological state, which in turn is determined
Ossama Moujaber, Ursula Stochaj
openaire +3 more sources
Single mRNP Analysis Reveals that Small Cytoplasmic mRNP Granules Represent mRNA Singletons
Cell Reports, 2019 Summary: Small cytoplasmic mRNP granules are implicated in mRNA transport, translational control, and decay. Using super-resolution microscopy and fluorescence correlation spectroscopy, we analyzed the molecular composition and dynamics of single ...
Àngels Mateu-Regué +5 more
doaj +2 more sources
Cytoplasmic RNA Granules and Viral Infection [PDF]
Annual Review of Virology, 2014 RNA granules are dynamic cellular structures essential for proper gene expression and homeostasis. The two principal types of cytoplasmic RNA granules are stress granules, which contain stalled translation initiation complexes, and processing bodies (P bodies), which concentrate factors involved in mRNA degradation.
Wei-Chih, Tsai, Richard E, Lloyd
openaire +3 more sources
Human Pathology: Case Reports, 2014 In the salivary gland, a key differential feature of Mammary analog secretory carcinoma (MASC) from acinic cell carcinoma (ACC) is the lack of cytoplasmic granules.
Nouf Hijazi, MD +3 more
doaj +2 more sources
Enrichment of Cytoplasmic RNA Granules from Arabidopsis Seedlings
Bio-Protocol, 2021 RNA granules (RGs) are membraneless intracellular compartments that play important roles in the post-transcriptional control of gene expression. Stress granules (SGs) are a type of RGs that form under environmental challenges and/or internal cellular ...
Zhen Lei, Eun Kim, Jungnam Cho
doaj +3 more sources
Methods to Classify Cytoplasmic Foci as Mammalian Stress Granules [PDF]
Journal of Visualized Experiments, 2017 Cells are often challenged by sudden environmental changes. Stress Granules (SGs), cytoplasmic ribonucleoprotein complexes that form in cells exposed to stress conditions, are implicated in various aspects of cell metabolism and survival. SGs modulate cellular signaling pathways, post-transcriptional gene expression, and stress response programs.
Anaïs, Aulas +5 more
openaire +3 more sources
Formation of Antiviral Cytoplasmic Granules during Orthopoxvirus Infection [PDF]
Journal of Virology, 2011 ABSTRACT Vaccinia virus (VV) mutants lacking the double-stranded RNA (dsRNA)-binding E3L protein (Δ E3L mutant VV) show restricted replication in most cell types, as dsRNA produced by VV activates protein kinase R (PKR), leading to eIF2α phosphorylation and impaired translation initiation.
M, Simpson-Holley +6 more
openaire +3 more sources