Results 11 to 20 of about 112,950 (205)
Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules [PDF]
Cell, 2021 Receptor tyrosine kinase (RTK)-mediated activation of downstream effector pathways such as the RAS GTPase/MAP kinase (MAPK) signaling cascade is thought to occur exclusively from lipid membrane compartments in mammalian cells. Here, we uncover a membraneless, protein granule-based subcellular structure that can organize RTK/RAS/MAPK signaling in cancer.
Tulpule, Asmin +19 more
exaly +5 more sources
Cytoplasmic RNA Granules and Viral Infection [PDF]
Annual Review of Virology, 2014 RNA granules are dynamic cellular structures essential for proper gene expression and homeostasis. The two principal types of cytoplasmic RNA granules are stress granules, which contain stalled translation initiation complexes, and processing bodies (P bodies), which concentrate factors involved in mRNA degradation.
Wei-Chih, Tsai, Richard E, Lloyd
openaire +4 more sources
Multiple Poliovirus Proteins Repress Cytoplasmic RNA Granules [PDF]
Viruses, 2015 We have previously shown that poliovirus (PV) infection induces stress granule (SG) formation early in infection and then inhibits the formation of SG and disperses processing bodies (PBs) by the mid-phase of infection.
Jonathan D. Dougherty +2 more
doaj +3 more sources
Cytoplasmic mRNP granules at a glance [PDF]
Journal of Cell Science, 2011 From their transcriptional birth to their degradation, cellular mRNAs are coated with proteins in messenger ribonucleoprotein (mRNP) complexes. The mRNP composition controls every aspect of the life of the mRNA, from pre-mRNA processing to mRNA localization, translation and turnover ...
Stacy L, Erickson, Jens, Lykke-Andersen
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Cytoplasmic RNA Granules in Somatic Maintenance [PDF]
Gerontology, 2018 Cytoplasmic RNA granules represent subcellular compartments that are enriched in protein-bound RNA species. RNA granules are produced by evolutionary divergent eukaryotes, including yeast, mammals, and plants. The functions of cytoplasmic RNA granules differ widely. They are dictated by the cell type and physiological state, which in turn is determined
Ossama Moujaber, Ursula Stochaj
openaire +2 more sources
Plasma cell myeloma with numerous cytoplasmic granules [PDF]
Blood, 2016 ![Figure][1] A 74-year-old woman presented with fatigue. Laboratory studies showed an 8.0 g/dL M spike and immunoglobulin G κ paraprotein. Wright-Giemsa–stained bone marrow aspirate revealed increased atypical plasma cells containing numerous, large, cytoplasmic azurophilic granules ...
Min Shi, Rong He
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Frontiers in Plant Science, 2021 Tudor staphylococcal nucleases (TSNs) are evolutionarily conserved RNA binding proteins, which include redundant TSN1 and TSN2 in Arabidopsis. It has been showed TSNs are the components of stress granules (SGs) and regulate plant growth under salt stress.
Yanan Liu +6 more
doaj +1 more source
CYTOPLASMIC GRANULE FORMATION IN MYELOCYTES [PDF]
The Journal of Cell Biology, 1966 The intracellular flow of tritiated lysine as revealed by electron microscope radioautography was studied in heterophilic myelocytes of rabbit marrow. Label over the Golgi complex rose to a maximum of 37% of total cytoplasmic grains 30 min after initial exposure to the tracer and fell to 11% after 3 to 4 hr of incubation.
Martha E. Fedorko, James G. Hirsch
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Principles of RNA recruitment to viral ribonucleoprotein condensates in a segmented dsRNA virus
eLife, 2023 Rotaviruses transcribe 11 distinct RNAs that must be co-packaged prior to their replication to make an infectious virion. During infection, nontranslating rotavirus transcripts accumulate in cytoplasmic protein-RNA granules known as viroplasms that ...
Sebastian Strauss +6 more
doaj +1 more source
Biology Open, 2016 Stress granules are cytoplasmic foci that directly respond to the protein synthesis status of the cell. Various environmental insults, such as oxidative stress or extreme heat, block protein synthesis; consequently, mRNA will stall in translation, and ...
Cecilia Zampedri +6 more
doaj +1 more source