Results 31 to 40 of about 62,398 (262)
Myo-granules Connect Physiology and Pathophysiology
Journal of Experimental Neuroscience, 2019 A hallmark of many neuromuscular diseases including Alzheimer disease, inclusion body myositis, amyotrophic lateral sclerosis, frontotemporal lobar dementia, and ocular pharyngeal muscular dystrophy is large cytoplasmic aggregates containing the RNA ...
Alicia A Cutler +4 more
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Stress granules regulate paraspeckles: RNP granule continuum at work
Cell Stress, 2019 Eukaryotic cells contain several types of RNA-protein membraneless macro-complexes – ribonucleoprotein (RNP) granules that form by liquid-liquid phase separation.
Haiyan An, Tatyana A. Shelkovnikova
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Nature Communications, 2017 Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent ...
Manuel D. Díaz-Muñoz +5 more
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The Role of the Z-DNA Binding Domain in Innate Immunity and Stress Granules
Frontiers in Immunology, 2021 Both DNA and RNA can maintain left-handed double helical Z-conformation under physiological condition, but only when stabilized by Z-DNA binding domain (ZDBD).
De Chen Chiang +4 more
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C. elegans germ granules sculpt both germline and somatic RNAome
Nature Communications, 2023 Germ granules are membrane-less organelles essential for small RNA biogenesis and germline development. Among the conserved properties of germ granules is their association with the nuclear membrane. Recent studies demonstrated that LOTUS domain proteins,
Ian F. Price +4 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Arrest of cytoplasmic streaming induces algal proliferation in green paramecia. [PDF]
PLoS ONE, 2007 A green ciliate Paramecium bursaria, bearing several hundreds of endosymbiotic algae, demonstrates rotational microtubule-based cytoplasmic streaming, in which cytoplasmic granules and endosymbiotic algae flow in a constant direction.
Toshiyuki Takahashi +3 more
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Aging RNA granule dynamics in neurodegeneration
Frontiers in Molecular Biosciences, 2022 Disordered RNA-binding proteins and repetitive RNA sequences are the main genetic causes of several neurodegenerative diseases, including amyotrophic lateral sclerosis and Huntington’s disease.
Kevin Rhine +13 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Neurobiology of Disease, 2022 Increasing genetic and biochemical evidence has broadened our view of the pathomechanisms that lead to Spinal muscular atrophy (SMA) and Amyotrophic lateral sclerosis (ALS), two fatal neurodegenerative diseases with similar symptoms and causes.
LiDan Hu +5 more
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