Results 51 to 60 of about 272,495 (294)

Aging RNA granule dynamics in neurodegeneration

Frontiers in Molecular Biosciences, 2022
Disordered RNA-binding proteins and repetitive RNA sequences are the main genetic causes of several neurodegenerative diseases, including amyotrophic lateral sclerosis and Huntington’s disease.
Kevin Rhine, Kevin Rhine, Kevin Rhine, Norah Al-Azzam, Norah Al-Azzam, Norah Al-Azzam, Norah Al-Azzam, Tao Yu, Tao Yu, Tao Yu, Gene W. Yeo, Gene W. Yeo, Gene W. Yeo, Gene W. Yeo   +13 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Stress granules in the spinal muscular atrophy and amyotrophic lateral sclerosis: The correlation and promising therapy

Neurobiology of Disease, 2022
Increasing genetic and biochemical evidence has broadened our view of the pathomechanisms that lead to Spinal muscular atrophy (SMA) and Amyotrophic lateral sclerosis (ALS), two fatal neurodegenerative diseases with similar symptoms and causes.
LiDan Hu, Shanshan Mao, Li Lin, Guannan Bai, Bingjie Liu, Jianhua Mao   +5 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Cellular stress induces cytoplasmic RNA granules in fission yeast

, 2010
Severe stress causes plant and animal cells to form large cytoplasmic granules containing RNA and proteins. Here, we demonstrate the existence of stress-induced cytoplasmic RNA granules in Schizosaccharomyces pombe.
Nilsson, Daniel,, Daniel Nilsson, Per Sunnerhagen, Sunnerhagen, Per,   +3 more
core   +1 more source

Rab3D is critical for secretory granule maturation in PC12 cells. [PDF]

, 2013
Neuropeptide- and hormone-containing secretory granules (SGs) are synthesized at the trans-Golgi network (TGN) as immature secretory granules (ISGs) and complete their maturation in the F-actin-rich cell cortex.
Sharon A. Tooze (391543), Kögel Tanja, Copier, J., Hodneland, E, Gerdes, HH, Gerdes Hans-Hermann, Tooze, S. A., Tooze Sharon A., Copier, J, Rüdiger Rudolf (151449), Tanja Kögel, Romano Regazzi, Rudolf Rüdiger, Copier John, Gerdes, H. H., Tooze, SA, Tanja Kögel (391540), Kögel, T., Hans-Hermann Gerdes, Kögel, T, Hodneland Erlend, John Copier, Tooze, S.A., Rudolf, R., Regazzi Romano, Regazzi, R, Erlend Hodneland, Gerdes, H.H., Erlend Hodneland (391541), Regazzi, R., Sharon A Tooze, Hodneland, E., John Copier (391542), Rudolf, R, Romano Regazzi (210061), Rüdiger Rudolf, Hans-Hermann Gerdes (127873)   +36 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Novel mRNA-silencing bodies at the synapse: A never-ending story

Communicative & Integrative Biology, 2016
Several cellular responses depend on translational regulation and in most cases, this involves the formation of cytoplasmic granules that contain repressed mRNAs.
María Gabriela Thomas, Graciela Lidia Boccaccio   +1 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Intracellular and intercellular transport of RNA organelles in CXG repeat disorders: The strength of weak ties

Frontiers in Molecular Biosciences, 2022
RNA is a vital biomolecule, the function of which is tightly spatiotemporally regulated. RNA organelles are biological structures that either membrane-less or surrounded by membrane.
Deepti Kailash Nabariya, Annika Heinz, Sabrina Derksen, Sybille Krauß   +3 more
doaj   +1 more source