Results 71 to 80 of about 272,495 (294)

Formation of Antiviral Cytoplasmic Granules during Orthopoxvirus Infection [PDF]

Journal of Virology, 2011
ABSTRACT Vaccinia virus (VV) mutants lacking the double-stranded RNA (dsRNA)-binding E3L protein (Δ E3L mutant VV) show restricted replication in most cell types, as dsRNA produced by VV activates protein kinase R (PKR), leading to eIF2α phosphorylation and impaired translation initiation.
M, Simpson-Holley, N, Kedersha, K, Dower, K H, Rubins, P, Anderson, L E, Hensley, J H, Connor   +6 more
openaire   +2 more sources

Morphological and Quantitative Aspects of the Development of Cytoplasmic Granules in Concanavalin A-Stimulated Normal Human Lymphocytes

, 1990
We have studied normal human lymphocytes stimulated by concanavalin A to determine the rate and extent of development of cytoplasmic granules. Morphological studies on stimulated lymphocytes were undertaken at the light and electron microscopic level ...
Anne McGirl, Giles Shea, Mary Melinn, Hugh McLaughlin   +3 more
core   +1 more source

A Supramolecular Thermal Switch for Precision Pyroptosis via Host−Guest Recognition and Electrostatic Interactions

Advanced Science, EarlyView.
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu, Jie Zhou, Yibin Cao, Kunmin Ping, Borui Zhao, Yanrong Yang, Chunyang Yu, Xinyang Yu, Shaolong Qi   +8 more
wiley   +1 more source

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source

Microfluidic assembly and packing dynamics of colloidal granules [PDF]

, 2010
Granular materials composed of primary colloidal particles are of both scientific and technological importance. The creation of granular systems for fundamental studies of their packing dynamics as well as applications ranging from ceramics processing ...
Shepherd, Robert F.
core  

ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules [PDF]

, 2013
Mutations in the gene encoding Fused in Sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. FUS is a predominantly nuclear DNA- and RNA-binding protein that is involved in RNA processing.
Miller, CC, Catherine Manser, Claire Troakes, Troakes, C, Claudia Kathe, Scotter, Emma, Boris Rogelj, Urwin, Hazel, Mitchell, JC, Scotter, EL, Kathe, Claudia, Nishimura, AL, Dragunow, M, Rogelj, Boris, Rogelj, B, Emma L. Scotter, Manser, Catherine, Urwin, H, Hortobágyi, Tibor, Shaw, Christopher E., Mitchell, Jacqueline C., Tibor Hortobágyi, Vance, Caroline; id_orcid, Agnes L. Nishimura, Nishimura, Agnes L., Caroline Vance, Jacqueline C. Mitchell, Dragunow, Mike, Dragunow, Michael, Shaw, CE, Vance, C, Scotter, Emma L., Troakes, Claire; id_orcid, Kathe, C, Hortobágyi, T, Manser, C, Mike Dragunow, Christopher E. Shaw, Hazel Urwin, Christopher C. Miller, Miller, Christopher C.; id_orcid   +40 more
core   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

Regulation of cytoplasmic stress granules by apoptosis-inducing factor [PDF]

Journal of Cell Science, 2004
Stress granules (SG) are dynamic cytoplasmic foci in which stalled translation initiation complexes accumulate. In conditions of acute cellular redox, stress cells manipulated to lose the expression of apoptosis-inducing factor (AIF) nucleate SG signature proteins (e.g. TIA-1, PABP1) more efficiently than AIF-positive controls.
Cande, C., Vahsen, N., Metivier, D., Tourriere, H., Chebli, K., Garrido, C., Tazi, J., Kroemer, G.   +7 more
openaire   +2 more sources

Novel mRNA-containing cytoplasmic granules in ALK-transformed cells

, 2011
In mammalian cells, nontranslating messenger RNAs (mRNAs) are concentrated in different cytoplasmic foci, such as processing bodies (PBs) and stress granules (SGs), where they are either degraded or stored.
Olivier Jean-Jean, Dominique Morello, Nathalie Vanzo, Mohamad Fawal   +3 more
core   +1 more source

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source