Results 51 to 60 of about 469,945 (221)

A novel link between Sus1 and the cytoplasmic mRNA decay machinery suggests a broad role in mRNA metabolism

BMC Cell Biology, 2010
Background Gene expression is achieved by the coordinated action of multiple factors to ensure a perfect synchrony from chromatin epigenetic regulation through to mRNA export.
Llopis Ana, García-Oliver Encar, Pascual-García Pau, García-Molinero Varinia, Cuenca-Bono Bernardo, Rodríguez-Navarro Susana   +5 more
doaj   +1 more source

The Role of the Z-DNA Binding Domain in Innate Immunity and Stress Granules

Frontiers in Immunology, 2021
Both DNA and RNA can maintain left-handed double helical Z-conformation under physiological condition, but only when stabilized by Z-DNA binding domain (ZDBD).
De Chen Chiang, De Chen Chiang, Yan Li, Siew Kit Ng, Siew Kit Ng   +4 more
doaj   +1 more source

Cytoplasmic hGle1A regulates stress granules by modulation of translation

Molecular Biology of the Cell, 2015
Stress granules and translation are in dynamic equilibrium, but the mechanisms regulating them are not fully defined. Here we show isoform-specific roles for human Gle1: Gle1B functions in mRNA export, whereas, during stress, Gle1A coordinates ...
Andrew W Aditi, Susan R Folkmann, Wente, Sandra Wolin   +3 more
semanticscholar   +1 more source

Myo-granules Connect Physiology and Pathophysiology

Journal of Experimental Neuroscience, 2019
A hallmark of many neuromuscular diseases including Alzheimer disease, inclusion body myositis, amyotrophic lateral sclerosis, frontotemporal lobar dementia, and ocular pharyngeal muscular dystrophy is large cytoplasmic aggregates containing the RNA ...
Alicia A Cutler, Theodore Eugene Ewachiw, Giulia A Corbet, Roy Parker, Brad B Olwin   +4 more
doaj   +1 more source

C. elegans germ granules sculpt both germline and somatic RNAome

Nature Communications, 2023
Germ granules are membrane-less organelles essential for small RNA biogenesis and germline development. Among the conserved properties of germ granules is their association with the nuclear membrane. Recent studies demonstrated that LOTUS domain proteins,
Ian F. Price, Jillian A. Wagner, Benjamin Pastore, Hannah L. Hertz, Wen Tang   +4 more
doaj   +1 more source

DEF6, a Novel Substrate for the Tec Kinase ITK, Contains a Glutamine-rich Aggregation-prone Region and Forms Cytoplasmic Granules that Co-localize with P-bodies*

Journal of Biological Chemistry, 2012
Background: DEF6 is recruited to the immunological synapse upon T cell receptor-mediated signaling regulating inflammatory responses including Experimental Autoimmune Encephalomyelitis.
Fiona Hey, Nathan Czyzewicz, Peter Jones, F. Sablitzky   +3 more
semanticscholar   +1 more source

Stress granules regulate paraspeckles: RNP granule continuum at work

Cell Stress, 2019
Eukaryotic cells contain several types of RNA-protein membraneless macro-complexes – ribonucleoprotein (RNP) granules that form by liquid-liquid phase separation.
Haiyan An, Tatyana A. Shelkovnikova
doaj   +1 more source

Arrest of cytoplasmic streaming induces algal proliferation in green paramecia. [PDF]

PLoS ONE, 2007
A green ciliate Paramecium bursaria, bearing several hundreds of endosymbiotic algae, demonstrates rotational microtubule-based cytoplasmic streaming, in which cytoplasmic granules and endosymbiotic algae flow in a constant direction.
Toshiyuki Takahashi, Yohji Shirai, Toshikazu Kosaka, Hiroshi Hosoya   +3 more
doaj   +1 more source

Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells

Nature Communications, 2017
Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent ...
Manuel D. Díaz-Muñoz, Vladimir Yu. Kiselev, Nicolas Le Novère, Tomaz Curk, Jernej Ule, Martin Turner   +5 more
doaj   +1 more source

Aging RNA granule dynamics in neurodegeneration

Frontiers in Molecular Biosciences, 2022
Disordered RNA-binding proteins and repetitive RNA sequences are the main genetic causes of several neurodegenerative diseases, including amyotrophic lateral sclerosis and Huntington’s disease.
Kevin Rhine, Kevin Rhine, Kevin Rhine, Norah Al-Azzam, Norah Al-Azzam, Norah Al-Azzam, Norah Al-Azzam, Tao Yu, Tao Yu, Tao Yu, Gene W. Yeo, Gene W. Yeo, Gene W. Yeo, Gene W. Yeo   +13 more
doaj   +1 more source