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Why Is Taurine Cytoprotective?
2003The concept that taurine exhibits cytoprotective activity was introduced in 1981. Although several studies at the time had supported the notion that taurine was capable of modulating Ca2+movement, most of those studies focused on the transporter affected by taurine.
Stephen, Schaffer +3 more
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Cytoprotective Channels in Mitochondria
Journal of Bioenergetics and Biomembranes, 2005Several ion channels are expressed in the inner and outer membranes of mitochondria, but the exact function of these channels is not completely understood. The opening of certain channels is thought to induce the process of cell death or apoptosis. However, other channels of the inner mitochondrial membrane help protect against ischemic injury and ...
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Cytoprotection and Stress Ulceration
Medical Clinics of North America, 1991The stomach possesses many mechanisms for protection against stress ulceration. The gastric microcirculation, prostaglandins, mucus secretion, epithelial cell renewal, and muscle tone are factors involved in gastric cytoprotection. Therapy is partially directed at augmenting these natural physiologic defense mechanisms to prevent and promote healing of
J, Pilchman, H B, Lefton, G L, Braden
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Indian journal of physiology and pharmacology, 1992
The term 'cytoprotection' means protection against gastric mucosal injury by a mechanism other than inhibition or neutralisation of gastric acid. Several mechanisms of gastric cytoprotection have been proposed like increased mucus and bicarbonate secretion, strengthening of gastric mucosal barrier, increased gastric mucosal blood flow, decreased ...
R S, D'Souza, V G, Dhume
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The term 'cytoprotection' means protection against gastric mucosal injury by a mechanism other than inhibition or neutralisation of gastric acid. Several mechanisms of gastric cytoprotection have been proposed like increased mucus and bicarbonate secretion, strengthening of gastric mucosal barrier, increased gastric mucosal blood flow, decreased ...
R S, D'Souza, V G, Dhume
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Cytoprotective therapies in stroke
Current Opinion in Neurology, 1995Cytoprotective strategies continue to be intensively investigated in animal models of focal and global ischaemia. New classes of pharmacological agents are still being identified which are effective in reducing the severity of ischaemic damage when administered shortly after the ischaemia.
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Current history of cytoprotection
Prostaglandins, 1981Abstract Several prostaglandins (PG) particularly those of the E type, inhibit gastric secretion in animals and humans. They also prevent ulcer formation and accelerate the rate of ulcer healing (gastric and duodenal, in animals and humans). The antiulcer activity was first ascribed to the antisecretory property.
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Coenzyme Q Cytoprotective Mechanisms
2004Publisher Summary This chapter provides an overview of coenzyme Q (CoQ) cytoprotective mechanisms. CoQ cytoprotective mechanisms can be divided into bioenergetic function and antioxidant activity. To discern to what extent these processes are occurring in cells during cell stress, it is necessary to measure the ability of the CoQ hydroquinone to both
Tom S, Chan +2 more
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European Journal of Cancer, 1996
The toxicity associated with chemotherapy is significant and dose limiting. Multiple organ systems can be affected, with both acute and chronic side effects producing adverse effects. The concept of cytoprotection, or the selective protection of normal tissues is a strategy now being investigated in preclinical and clinical models.
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The toxicity associated with chemotherapy is significant and dose limiting. Multiple organ systems can be affected, with both acute and chronic side effects producing adverse effects. The concept of cytoprotection, or the selective protection of normal tissues is a strategy now being investigated in preclinical and clinical models.
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Cytoprotection and intracellular calcium
Journal of Physiology-Paris, 1999It seems that prostacyclin has an increasing effect on gastric mucosal (antral and fundic) calmodulin level in rats. Using either the calcium channel blocker verapamil or anti-calmodulin drugs (diazepam, trifluoperazine,) the cytoprotective effect of prostacyclin can be inhibited.
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Cytoprotection: concepts and challenges
Supportive Care in Cancer, 1994Clinical trials with several toxicity protectors (cytoprotective or chemoprotective agents) have been performed during the past decade. These trials are quite complex since they must include sufficient dose-limiting events for study, and assessment of both toxicity (and therefore the efficacy of protection) and antitumor effects must be carried out ...
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