Results 191 to 200 of about 22,691 (239)

Mechanisms of Gastric Cytoprotection

Journal of Clinical Gastroenterology, 1987
Gastric cytoprotection is a real but relative phenomenon that is induced by both endogenous and exogenous compounds. The key element in acute mucosal protection is the preservation of vascular integrity and the resulting maintenance of blood flow.
S, Szabo, G, Pihan
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Cytoprotection and Stress Ulceration

Medical Clinics of North America, 1991
The stomach possesses many mechanisms for protection against stress ulceration. The gastric microcirculation, prostaglandins, mucus secretion, epithelial cell renewal, and muscle tone are factors involved in gastric cytoprotection. Therapy is partially directed at augmenting these natural physiologic defense mechanisms to prevent and promote healing of
J, Pilchman, H B, Lefton, G L, Braden
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Current history of cytoprotection

Prostaglandins, 1981
Abstract Several prostaglandins (PG) particularly those of the E type, inhibit gastric secretion in animals and humans. They also prevent ulcer formation and accelerate the rate of ulcer healing (gastric and duodenal, in animals and humans). The antiulcer activity was first ascribed to the antisecretory property.
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Cytoprotective Channels in Mitochondria

Journal of Bioenergetics and Biomembranes, 2005
Several ion channels are expressed in the inner and outer membranes of mitochondria, but the exact function of these channels is not completely understood. The opening of certain channels is thought to induce the process of cell death or apoptosis. However, other channels of the inner mitochondrial membrane help protect against ischemic injury and ...
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Cytoprotection: concepts and challenges

Supportive Care in Cancer, 1994
Clinical trials with several toxicity protectors (cytoprotective or chemoprotective agents) have been performed during the past decade. These trials are quite complex since they must include sufficient dose-limiting events for study, and assessment of both toxicity (and therefore the efficacy of protection) and antitumor effects must be carried out ...
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Cytoprotection and intracellular calcium

Journal of Physiology-Paris, 1999
It seems that prostacyclin has an increasing effect on gastric mucosal (antral and fundic) calmodulin level in rats. Using either the calcium channel blocker verapamil or anti-calmodulin drugs (diazepam, trifluoperazine,) the cytoprotective effect of prostacyclin can be inhibited.
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Overview of clinical cytoprotection

Digestive Diseases and Sciences, 1985
In thinking about cytoprotection five questions seem pertinent: (i) what is 'cytoprotection'? For convenience I shall use this term in spite of the semantic controversies between certain centers. (ii) How does cytoprotection occur? In other words what are the mechanisms that impart protection to the surface epithelial cells of the stomach and duodenum?
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Direct and adaptive cytoprotection

Digestive Diseases and Sciences, 1986
Cytoprotection confers increased cellular resistance to various damaging challenges. For example, the administration of certain prostaglandins (PG) prevents injury or facilitates recovery from injury in tissues exposed to noxious substances, such as ethanol, aspirin, and indomethacin.
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PROSTAGLANDINS, NSAIDs, AND CYTOPROTECTION

Gastroenterology Clinics of North America, 1992
Although the effects of prostaglandins on gastrointestinal secretion, blood flow, and motility are quite well characterized, the mechanism underlying the cytoprotective actions of this group of lipid mediators has yet to be clearly established. It seems likely that the ability of NSAIDs to inhibit gastric prostaglandin synthesis is an important ...
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Prostaglandins and gastrointestinal cytoprotection.

Acta physiologica Hungarica, 1983
One of the important and interesting effects of prostaglandins in the gastrointestinal tract is cytoprotection: protection of the gastrointestinal mucosa against nonspecific injuries (physical, chemical, drugs, etc.). The characteristic features of cytoprotection, the possible mechanism of protection and the theoretical and clinical perspectives of ...
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