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Overview of clinical cytoprotection
Digestive Diseases and Sciences, 1985In thinking about cytoprotection five questions seem pertinent: (i) what is 'cytoprotection'? For convenience I shall use this term in spite of the semantic controversies between certain centers. (ii) How does cytoprotection occur? In other words what are the mechanisms that impart protection to the surface epithelial cells of the stomach and duodenum?
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PROSTAGLANDINS, NSAIDs, AND CYTOPROTECTION
Gastroenterology Clinics of North America, 1992Although the effects of prostaglandins on gastrointestinal secretion, blood flow, and motility are quite well characterized, the mechanism underlying the cytoprotective actions of this group of lipid mediators has yet to be clearly established. It seems likely that the ability of NSAIDs to inhibit gastric prostaglandin synthesis is an important ...
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Direct and adaptive cytoprotection
Digestive Diseases and Sciences, 1986Cytoprotection confers increased cellular resistance to various damaging challenges. For example, the administration of certain prostaglandins (PG) prevents injury or facilitates recovery from injury in tissues exposed to noxious substances, such as ethanol, aspirin, and indomethacin.
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Prostaglandins and gastrointestinal cytoprotection.
Acta physiologica Hungarica, 1983One of the important and interesting effects of prostaglandins in the gastrointestinal tract is cytoprotection: protection of the gastrointestinal mucosa against nonspecific injuries (physical, chemical, drugs, etc.). The characteristic features of cytoprotection, the possible mechanism of protection and the theoretical and clinical perspectives of ...
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1984
Gastric cytoprotection is the property of certain substances, particularly prostaglandins, to protect the gastric mucosa from becoming inflamed and necrotic when exposed to noxious agents. The protection occurs under the surface epithelium that lines the gastric mucosa.
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Gastric cytoprotection is the property of certain substances, particularly prostaglandins, to protect the gastric mucosa from becoming inflamed and necrotic when exposed to noxious agents. The protection occurs under the surface epithelium that lines the gastric mucosa.
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Cytoprotective Therapy Prostaglandins
1989Prostaglandins are 20-carbon cyclic fatty acids synthesized from dietary fatty acids by virtually all mammalian cells. These naturally occurring compounds are biologically active, affect most cellular functions, and have both physiologic and pharmacologic effects in animals and in humans.
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