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Occurrence, Properties, Applications and Analytics of Cytosine and Its Derivatives [PDF]
MoleculesCytosine and its derivatives are an important research topic in the fields of bioorganic chemistry, molecular biology and medicine due to their key role in the structure and function of nucleic acids.
Mariusz Kluska +3 more
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Cytosine base editor-DNA binding domain fusions for editing window modulation in the RNP format [PDF]
BMC BiotechnologySummary Base editing technologies allow for the precise and efficient installation of defined nucleotide substitutions into a target genome without the introduction of double strand breaks or DNA templates.
Erin Brettmann +3 more
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Frontiers in Immunology, 2022 B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood malignancy. The cure rate has reached 90% after conventional chemotherapy and hematopoietic stem cell transplantation (HSCT), but the prognosis of patients with relapsed and ...
Lei Deng +10 more
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N-4 Alkyl Cytosine Derivatives Synthesis: A New Approach
Reactions, 2022 The selective N-4 alkylation of cytosine plays a critical role in the synthesis of biologically active molecules. This work focuses on the development of practical reaction conditions toward a regioselective synthesis of N-4-alkyl cytosine derivatives ...
Mauro De Nisco +7 more
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Molecules, 2021 Thymine DNA Glycosylase (TDG) is an enzyme of the base excision repair mechanism and removes damaged or mispaired bases from DNA via hydrolysis of the glycosidic bond. Specificity is of high importance for such a glycosylase, so as to avoid the damage of
Senta Volkenandt +2 more
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Adsorption of Nucleic Acid Bases, Ribose, and Phosphate by Some Clay Minerals
Life, 2015 Besides having a large capacity for taking up organic molecules, clay minerals can catalyze a variety of organic reactions. Derived from rock weathering, clay minerals would have been abundant in the early Earth. As such, they might be expected to play a
Hideo Hashizume
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Frontiers in Chemistry, 2018 Cytosine, a DNA and RNA building-block, and Metformin, the most widely prescribed drug for the treatment of Type 2 Diabetes mellitus were made to react separately with ammonium or sodium metavanadates in acidic aqueous solutions to obtain two ...
Eduardo Sánchez-Lara +7 more
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Hydrogen-bonding patterns in bis(cytosinium) tartarate monohydrate
IUCrData, 2017 The asymmetric unit of the title cystosinium salt derivative, 2C4H6N3O+·C4H4O62−·H2O, contains two cytosinium cations, one tartaric acid anion and a water molecule. The two cytosinium cations are almost planar (r.m.s. deviations of the fitted atoms are 0.
P. Jaikumar +4 more
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Neuropsychopharmacology Reports, 2020 Background Commercially available Illumina DNA methylation arrays (HumanMethylation 27K, HumanMethylation450, and MethylationEPIC BeadChip) can be used for comprehensive DNA methylation analyses of not only the human genome but also other mammalian ...
Yutaka Nakachi +4 more
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