Results 1 to 10 of about 52,762 (171)
Molecular Cancer, 2020 Background Literature reports that mature microRNA (miRNA) can be methylated at adenosine, guanosine and cytosine. However, the molecular mechanisms involved in cytosine methylation of miRNAs have not yet been fully elucidated.
Mathilde Cheray +15 more
doaj +2 more sources
Frontiers in Genetics, 2015 DNA cytosine methylation is a widespread epigenetic mechanism in eukaryotes, and plant genomes commonly are densely methylated. Genomic methylation can be associated with functional consequences such as mutational events, genomic instability or altered ...
Conchita eAlonso +3 more
doaj +2 more sources
PLoS ONE, 2015 While cytosine methylation has been widely studied in extant populations, relatively few studies have analyzed methylation in ancient DNA. Most existing studies of epigenetic marks in ancient DNA have inferred patterns of methylation in highly degraded ...
Rick W A Smith +2 more
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Improved cytosine base editors generated from TadA variants
Nature Biotechnology, 2023 Cytosine base editors (CBEs) enable programmable genomic C·G-to-T·A transition mutations and typically comprise a modified CRISPR–Cas enzyme, a naturally occurring cytidine deaminase, and an inhibitor of uracil repair.
Dieter K. Lam +15 more
semanticscholar +1 more source
Frontiers in Immunology, 2022 B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood malignancy. The cure rate has reached 90% after conventional chemotherapy and hematopoietic stem cell transplantation (HSCT), but the prognosis of patients with relapsed and ...
Lei Deng +10 more
doaj +1 more source
Nature Biotechnology, 2022 Improved cytosine base editors are generated by phage-assisted evolution of a deoxyadenosine deaminase. Cytosine base editors (CBEs) are larger and can suffer from higher off-target activity or lower on-target editing efficiency than current adenine base
M. Neugebauer +13 more
semanticscholar +1 more source
Modeling of nucleobase/oligonucleotide interaction with graphene and graphene oxide: the role of charging and/or oxidizing the graphene surface [PDF]
Mol. Cryst. Liq. Cryst. 2020, Vol. 697(1), 49-59, 2021 We analyze the influence of the charge and the degree of oxidation of the surface of graphene (Gr) on its interaction with cytosine and oligonucleotide r(C)10. This is a computational study involving DFT calculations and molecular dynamics simulations. It is shown that cytosine interacts stronger with graphene oxide (GO) than with Gr, while the energy ...
arxiv +1 more source
Characteristics and efficacy of cytosine and cytidine deaminase [PDF]
مجلة التربية والعلم, 2007 The study concerned with determination of some properties of cytosine deaminase activity in serum and erythrocytes haemolysate in normal human individuals, by spectral method.
Qusay Chalabi, Zahraa Hammodat
doaj +1 more source
Nature Communications, 2020 Cytosine base editors (CBEs) enable efficient, programmable reversion of T•A to C•G point mutations in the human genome. Recently, cytosine base editors with rAPOBEC1 were reported to induce unguided cytosine deamination in genomic DNA and cellular RNA ...
Yi Yu +8 more
semanticscholar +2 more sources
N-4 Alkyl Cytosine Derivatives Synthesis: A New Approach
Reactions, 2022 The selective N-4 alkylation of cytosine plays a critical role in the synthesis of biologically active molecules. This work focuses on the development of practical reaction conditions toward a regioselective synthesis of N-4-alkyl cytosine derivatives ...
Mauro De Nisco +7 more
doaj +1 more source