Results 121 to 130 of about 15,248 (235)

An innovative approach using CRISPR-ribonucleoprotein packaged in virus-like particles to generate genetically engineered mouse models

Nature Communications
Genetically engineered mouse models (GEMMs) are crucial for investigating disease mechanisms, developing therapeutic strategies, and advancing fundamental biological research. While CRISPR gene editing has greatly facilitated the creation of these models,
Tae Yeong Jeong, Da Eun Yoon, Sol Pin Kim, Jiyun Yang, Soo-Yeon Lim, Sungjin Ok, Sungjin Ju, Jeongeun Park, Su Bin Lee, Soo-Ji Park, Sanghun Kim, Hyunji Lee, Daekee Lee, Soo Kyung Kang, Seung Eun Lee, Hyeon Soo Kim, Je Kyung Seong, Kyoungmi Kim   +17 more
doaj   +1 more source

In Situ Construction of Phosphorus‐Containing Crosslinked Urethane Network Combined With Ammonium Polyphosphate via Reactive Blending for Enhancing Flame Retardancy and Anti‐Dripping Performance of Polylactic Acid Composites

Safety Science and Technology, EarlyView.
By in situ reaction blending, DOPO‐HQ and THEIC were added to PLA with MDI to construct a phosphorus containing polyurethane network, which significantly improved the flame retardant and anti‐dripping properties of polylactic acid composites. ABSTRACT Polylactic acid (PLA) is highly flammable and prone to severe melt dripping during combustion, which ...
Chiyuan Chen, Sadiqa Khan, Hongyu Yang, Xiaming Feng, Chaojun Wan   +4 more
wiley   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

Red lines and green lights: Gene therapy for inherited erythroid disorders beyond the haemoglobinopathies

British Journal of Haematology, EarlyView.
Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi, Nandakumar Natarajan, Kathryn E. Dickerson, Richard A. Voit   +3 more
wiley   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2‐m5C Modified ATF4 mRNA

Cancer Science, EarlyView.
The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Yanwei Li, Shuang Li, Yang Li, Zhanyu Pan   +3 more
wiley   +1 more source

TadA-Derived Cytosine Base Editor for Precise Genome Editing in Zebrafish

Abstract CRISPR base editors are crucial for precise genome manipulation. Existing APOBEC-based cytosine base editors (CBEs), while powerful, exhibit indels and sequence context limitations, where TC-context preferences restrict effective editing of CC and GC motifs.
Wei Qin, Sheng-Jia Lin, Cassidy Petree, Pratishtha Varshney, Gaurav K. Varshney   +4 more
openaire   +1 more source

Ionizing Radiation and Ultraviolet Light Irradiation‐Associated DNA Damage Increasing Genomic Instability Risk

Cancer Science, EarlyView.
UV irradiation induces two major types of pyrimidine dimers, CPDs and 6–4PPs. Whereas 6–4PPs efficiently induce cell‐cycle arrest, CPDs do not and frequently persist into S phase. As a result, DSBs can arise in the presence of unrepaired CPDs after 6–4PPs have been repaired, increasing the risk of genomic instability.
Ken‐ichi Yoshioka, Yusuke Matsuno, Rika Kusumoto‐Matsuo   +2 more
wiley   +1 more source

Clues of ancient incomplete lineage sorting during bivalve evolution undermine support for Heterodonta

Cladistics, EarlyView.
Abstract A long‐standing challenge in phylogenomics has been the resolution of relationships originated from ancient radiations. In these cases, phenomena such as incomplete lineage sorting can increase the support for conflicting resolutions. Most of the diversity in the Class Bivalvia originated during an Ordovician radiation; indeed, several deep ...
Alessandro Formaggioni, Takeshi Takeuchi, Mayuko Hamada, Kazuhiro Saito, Tatsuya Sakamoto, Noriyuki Satoh, Federico Plazzi, Marco Passamonti   +7 more
wiley   +1 more source

KU80 suppresses endonuclease G activity to preserve genomic integrity

The FEBS Journal, EarlyView.
Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan, Kwang‐Hyun Park, Hae Ryung Chang, Eunyoung Jung, Myung‐Jin Kim, Jeeyoon Kang, Hyunjo Shim, Eui‐Jeon Woo, Yonghwan Kim   +8 more
wiley   +1 more source