Results 191 to 200 of about 15,403 (255)

BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments. [PDF]

Genome Biol
Dinçer C, Fussing B, Garnett MJ, Coelho MA.   +3 more
europepmc   +1 more source

Gene editing of the GJB2 locus in porcine embryos using CRISPR/Cas9 and cytosine base editors: toward a model of congenital deafness. [PDF]

Sci Rep
Piñeiro-Silva C, Bermejo-Álvarez P, García-Purriños FJ, Gadea J.   +3 more
europepmc   +1 more source

Quantitative Control of Transposable Elements: From Genome Plasticity to Immune Regulatory Circuits

Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.
ABSTRACT Transposable elements (TEs) constitute nearly half of the human genome and are increasingly recognized as context‐dependent regulators of genome function rather than passive repetitive DNA. This Review synthesizes classical and recent evidence on TE biology, including TE classification, mechanisms of mobilization, host restriction pathways ...
Irving Jesús Reyes‐Barragán
wiley   +1 more source

Efficient and Safe Knockout of <i>AR</i> and <i>DMRT1</i> Mediated by Cytosine Base Editors in Chicken DF-1 and PGCs. [PDF]

Vet Sci
Gao X, Tang N, Zhao Z, He Y, Shen Y, Zou X, Luo C.   +6 more
europepmc   +1 more source

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment

MedComm, Volume 7, Issue 7, July 2026.
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li, Yating Sun, Shuibin Lin, Quan Yuan   +3 more
wiley   +1 more source

Advances in CRISPR Base Editing: From Molecular Evolution to Therapeutic Applications in Genomic Medicine. [PDF]

J Cell Mol Med
Aliciaslan M, Erbasan E, Erendor F, Sanlioglu S.   +3 more
europepmc   +1 more source

Proteomic Profiling of Primary Hippocampal Neurons Reveals Noncanonical GFAP Expression and Metabolic Adaptations in Glia‐Free Culture

PROTEOMICS, Volume 26, Issue 7, Page 111-130, July 2026.
ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz, Kinga Gostomska‐Pampuch, Natalia Pudełko‐Malik, Mariusz Fleszar, Agnieszka Gizak, Jacek R. Wiśniewski, Dariusz Rakus   +6 more
wiley   +1 more source

Expanding the genetic toolkit: adenine and cytosine base editors for gene disruption in Aspergillus niger. [PDF]

Microb Cell Fact
Yuan G, Deng S, Dai Z, Hofstad BA, Pomraning KR.   +4 more
europepmc   +1 more source

Molecular Characterisation of Orf Virus in Goats From Eastern Türkiye

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
This study provides the molecular characterisation of Orf virus (ORFV) strains circulating in Türkiye. Phylogenetic analysis of F1L, B2L, and VIR genes reveals high genetic similarity with Asian and global isolates, highlighting the importance of multi‐gene analysis in monitoring viral outbreaks and understanding disease origins.
Remziye Özbek, Mehmet Ilgın, Kezban Can‐Şahna   +2 more
wiley   +1 more source

Sequence context and methylation interact to shape germline mutation rate variation at CpG sites. [PDF]

PLoS Genet
Chandra S, Gao Z.
europepmc   +1 more source