Results 191 to 200 of about 15,248 (235)

Mitochondrial Base Editing of the m.8993T>G Mutation Restores Bioenergetics and Neural Differentiation in Patient iPSCs. [PDF]

Genes (Basel)
Yin L, Yin A, Jones M.
europepmc   +1 more source

Designing the MyoFusion Media: A Serum‐Free Medium Optimized for Bovine Satellite Cell Differentiation

Biotechnology and Bioengineering, Volume 123, Issue 8, Page 2048-2061, August 2026.
ABSTRACT Cultivated meat production requires efficient differentiation of muscle progenitor cells into myotubes without relying on animal‐derived serum, which poses ethical and scalability challenges. This study aimed to develop a chemically defined, serum‐free medium optimized for bovine satellite cell differentiation.
Aysenaz Tavsanli, Viktor Milkevych, Jette Feveile Young, Martin Krøyer Rasmussen   +3 more
wiley   +1 more source

5mC and 6mA DNA Methylation in the Fungal Kingdom: From Genome Defense to Epigenetic Regulation. [PDF]

Epigenomes
Malyshev DP, Belov VV, Gromova ES, Eremin AA, Zvereva MI, Sergeev AV.   +5 more
europepmc   +1 more source

A Modular Nucleoside Kinase Cascade for the Synthesis of Ribonucleoside Triphosphates

Biotechnology and Bioengineering, Volume 123, Issue 8, Page 2180-2191, August 2026.
Damm et al. report standardized enzymatic cascades for production of all canonical nucleoside triphosphates from the corresponding nucleosides, using kinase‐catalyzed phosphorylation from acetyl phosphate. Reactions afforded ∼ 100 mM product in near‐quantitative conversion.
Oliver T. Damm, Martin Pfeiffer, Johannes Zöhrer, Bernd Nidetzky   +3 more
wiley   +1 more source

Synonymous editing alters ion channel function, favoring prime editing for retinal disease correction. [PDF]

Int J Biol Sci
Kabra M, Moosajee M, Navarrete A, Newby GA, Rawding P, Xie R, Mechoulam H, Rivera A, Hung A, Tiwari S, Waxman AJ, Molugu K, Saha K, Gong S, Liu DR, Pattnaik BR.   +15 more
europepmc   +1 more source

Epigenetic Mechanisms Underlying Cognitive Dysfunction in Parkinson's Disease: Current Evidence and Future Prospects

Brain and Behavior, Volume 16, Issue 8, August 2026.
Epigenetic mechanismsincluding DNA methylation, histone modifications, and microRNA (miRNA) regulationmodulate gene expression without altering the DNA sequence and are increasingly implicated in the cognitive impairment associated with Parkinson's disease (PD). Environmental and molecular factors influence these epigenetic pathways, leading to altered
Fatemeh Hasani, Mohammad Ebrahim Kherad, Mohammad Sharifi Sarasyabi, Kimia Jazi, Ali Ashkbari, Payam Ahmadi, Hadise Heidarpour, Mahdi Masrour, Sina Khamaki, Rahem Rahmati, Andrei Surguchov   +10 more
wiley   +1 more source

Patient‐Derived Organoid‐Based CRISPR Screens in Cancer Research: Applications, Advances, and Challenges

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Patient‐derived organoids (PDOs) have emerged as physiologically relevant cancer models that preserve key genetic, histological, and functional features of the tumors from which they are derived. In parallel, CRISPR‐based perturbation technologies have transformed functional genomics by enabling scalable interrogation of gene function.
Julianne du Plessis, Aadilah Omar
wiley   +1 more source

Unnatural Cytosine Analogs Potentiate a Customizable, Enzymatic Method for Integrated Epigenetic and Four-Base Genetic Sequencing. [PDF]

J Am Chem Soc
Loo CE, Parker JB, Barka A, Zhu R, Schnell MR, Cuomo RG, Zhu H, Liu L, Chen A, Gill J, Zhou W, Kohli RM.   +11 more
europepmc   +1 more source

Clonal Hematopoiesis in Colorectal Cancer: Mechanisms and Implications

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Clonal hematopoiesis (CH) arises from the expansion of hematopoietic stem and progenitor cells bearing somatic mutations, often in genes linked to epigenetic regulation and inflammation. Once considered a benign age‐related phenomenon, CH has gained increasing attention for its potential to influence cancer biology beyond hematologic ...
Chenyue Xia, Yi Lu, Jinhui Gu
wiley   +1 more source

Whole-genome sequence of a human adenovirus species E strain identified from Kerala, India. [PDF]

Microbiol Resour Announc
Anukumar B, Kappala D, Jadhav SM, Nhavilthodi S, Peter A, Purushothaman SK.   +5 more
europepmc   +1 more source