Results 171 to 180 of about 25,918 (263)

Improved base editing and functional screening in <i>Leishmania</i> via co-expression of the AsCas12a ultra variant, a T7 RNA polymerase, and a cytosine base editor. [PDF]

Elife
Herrmann May N, Cao A, Schmid A, Link F, Arias-Del-Angel J, Meiser E, Beneke T.   +6 more
europepmc   +1 more source

Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing. [PDF]

Nat Commun, 2019
McGrath E, Shin H, Zhang L, Phue JN, Wu WW, Shen RF, Jang YY, Revollo J, Ye Z.   +8 more
europepmc   +1 more source

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

Author Correction: Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation. [PDF]

Nat Commun
Li G, Dong X, Luo J, Yuan T, Li T, Zhao G, Zhang H, Zhou J, Zeng Z, Cui S, Wang H, Wang Y, Yu Y, Yuan Y, Zuo E, Xu C, Huang J, Zhou Y.   +17 more
europepmc   +1 more source

Precise Creation of Elite Multilocular Germplasm Using a CBE NG System in Brassica napus

Plant Biotechnology Journal, EarlyView.
Huailin Li, Limin Hu, Yang Yu, Sukanta Bala, Yungu Zhai, Yang Yang, Xiaoxiao Shen, Hanzi He, Chuchuan Fan   +8 more
wiley   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Engineering Herbicide Cross‐Resistance in Rapeseed by Generating Stacked BnaALS Mutations via Sequential CBE and ABE8e‐SpRY Editing

Plant Biotechnology Journal, EarlyView.
Sichao Ren, Wenjing Lei, Jiaqi He, Meng Jia, Yu Liu, Jialin Fan, Yumei Wang, Li Lin, Hui Zhang, Youping Wang, Jian Wu   +10 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Genome Editing in Root and Tuber Crop Development in Sub‐Saharan Africa

Plant-Environment Interactions, Volume 7, Issue 3, June 2026.
ABSTRACT Precision genome editing, particularly using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR‐associated protein 9 (Cas9), is advancing crop improvement by enabling targeted and efficient genetic modifications. Root and tuber crops such as potato, cassava, sweet potato, and yam are vital for global food and nutritional
Himanshu Saini, Rohit Kumar, Manjeet, Srinu Banothu, Suram Likhita Reddy, Rajesh Gudihalli Munivenkatappa, Sri Sai Siddartha Naik, Roop Kumar, Rahul Pradhan   +8 more
wiley   +1 more source