Results 181 to 190 of about 15,248 (235)

Therapeutic adenine base editor with minimized off-target effects. [PDF]

Protein Cell
Sun Y, Yan N, Feng H, Lu H, Zuo Z, Zhou C, Zuo E.   +6 more
europepmc   +1 more source

APOBEC3A is the predominant global editor of cytosines in human mRNAs and in single-strand RNA viruses. [PDF]

G3 (Bethesda)
Kockler ZW, Bostan H, Klimczak LJ, Hsiao YC, Dennen MS, Cook ME, Mertz TM, Perelygina L, Kazanov MD, Li JL, Roberts SA, Gordenin DA.   +11 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, Volume 16, Issue 8, Page 1509-1526, August 2026.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, Volume 13, Issue 43, 3 August 2026.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source

Engineering Compact Base Editors by AlphaFold-Guided Mutation Scan and Escherichia coli-Based Tri-Selection. [PDF]

Adv Sci (Weinh)
Gang Son R, Kim G, Lee JK.
europepmc   +1 more source

Ligand‐Defined Interfacial Chemistry Enables Instant and Sequence‐General DNA Chemisorption on Gold Nanoparticles Toward Label‐Free SERS With Single‐Base Resolution

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Ascorbic Acid‐Engineered Interface Enables Universal DNA Functionalization on Gold Nanoparticles: Attenuating electrostatic repulsion and leveraging synergistic hydrogen‐bonding interactions significantly lowers the kinetic barrier for DNA adsorption, enabling rapid and sequence‐general functionalization of non‐thiolated DNA‐requiring only a single ...
Guangping Li, Cheng Wang, Xinyue Wu, Zhongxiang Ding, Heng Gao, Zhonggang Liu, Yu Zhang, Jinai Chen, Feng Wang, Honglin Liu   +9 more
wiley   +1 more source

Engineered transformer base editor with unconstrained PAM requirements. [PDF]

Mol Ther Nucleic Acids
Chen B, Tian Y, Liang L, Ding P, Yin R, Xu R, Wang T, Chen H, Lu D.   +8 more
europepmc   +1 more source

Ancient Plumage Colour Genetics Reveal Goose Domestication and Hybridization

Animal Genetics, Volume 57, Issue 4, August 2026.
ABSTRACT In archaeological assemblages, differentiating the European domestic goose and its wild progenitor, the greylag goose (Anser anser), has been challenging due to their similar skeletal morphologies. A short region of mitochondrial DNA (mtDNA) analysed from ancient DNA (aDNA) has been shown to distinguish wild greylags from domestic geese, but ...
Johanna Honka, Suvi Olli, Arthur O. Askeyev, Igor V. Askeyev, Oleg V. Askeyev, Jouni Aspi, Dilyara N. Shaymuratova, Laura Kvist   +7 more
wiley   +1 more source

Regulated transformation system (RTS): sddi-mediated programmable shut-off and mode switching of base editors. [PDF]

Nucleic Acids Res
Deng J, Zhou J, Xiang H, Li X, Han X, Weng Z, Jia J, Shao Y, Sima Y, Niu M, Li D, Ouyang H, Xu B, Pang D, Yang L, Yuan H.   +15 more
europepmc   +1 more source

miR155, triplicated in Down syndrome, regulates the development of neural stem cells and GABAergic interneurons in Alzheimer's disease mouse and human iPSC models

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Dysfunctional microRNAs and GABAergic interneurons are features of Alzheimer's disease (AD). The role of neuronal microRNA155 (miR155), elevated in both AD and Down syndrome (DS), remains unknown. METHODS We utilized in silico analyses of published databases, MIR155‐deleted and ‐overexpressing human induced pluripotent stem cell ...
Xiaodong Zhu, Jean‐Vianney Haure‐Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al‐subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E. Ehrlich   +10 more
wiley   +1 more source