Results 81 to 90 of about 25,918 (263)

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Development of cytosine and adenine base editors for maize precision breeding

Journal of Integrative Plant Biology
ABSTRACTBase editing technologies can improve crops, but their efficiency in maize remains suboptimal. This study attempts to overcome these limitations by examining optimized cytosine and adenine base editors (CBEs and ABEs), namely evoAPOBEC1, evoFERNY, evoCDA1, TadA8.20, and TadA8e, for precise genome editing in transient and stable expression maize
Xiao Fu, Nan Wang, Lina Li, Dexin Qiao, Xiantao Qi, Changlin Liu, Zhaoxu Gao, Chuanxiao Xie, Jinjie Zhu   +8 more
openaire   +2 more sources

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source

Construction and optimization of a base editor based on the MS2 system

Animal Models and Experimental Medicine, 2019
Background Catalytic defect Cas9‐cytosine deaminase fusion is widely used in base editing. The Multiple copy numbers of the MS2 binding site (MBS) can recruit multiple MS2 coat proteins (MCPs), which are usually applied to amplify signals.
Shuzhen Zhang, Songjie Feng, Wen Jiang, Xingxu Huang, Jieping Chen   +4 more
doaj   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Psychiatric and Cognitive Features in Italian Women With the FMR1 Premutation: A Comprehensive Assessment Using SCID‐5 and Standardized Cognitive Measures

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Women with the FMR1 premutation (PM) are at increased risk for fragile X‐associated conditions (FXPAC), including cognitive and psychiatric features collectively termed fragile X‐associated neuropsychiatric disorders (FXAND). This study is the first to systematically investigate cognitive and psychiatric features in Italian female premutation ...
Federica Alice Maria Montanaro, Randi J. Hagerman, Giuseppina Spano, Flora Tassone, Giancarlo Logroscino, Andrea Bosco   +5 more
wiley   +1 more source

Gene up-regulation by DNA demethylation in 35S-gshI-transgenic poplars (Populus x canescens) [PDF]

, 2008
Gene expression levels of transgene 35S-gshI (γ-glutamylcysteine synthetase) cloned from E. coli, and the endogenous gene gsh1 of poplar (Populus x canescens) were upregulated by the DNA demethylating agent DHAC (5,6-dihydro-5'-azacytidine ...
Bittsánszky, András, Gullner, Gábor, Gyulai, Gábor, Heszky, László, Kiss, J., Kőmíves, Tamás, Szabó, Zoltán, Tóth, Z.   +7 more
core  

Functionalized nanopore-embedded electrodes for rapid DNA sequencing [PDF]

, 2007
The determination of a patient's DNA sequence can, in principle, reveal an increased risk to fall ill with particular diseases [1,2] and help to design "personalized medicine" [3].
Ahuja, Rajeev, Grigoriev, Anton, He, Haiying, Karna, Shashi P., Pandey, Ravindra, Rocha, Alexandre Reily, Sanvito, Stefano, Scheicher, Ralph H.   +7 more
core   +1 more source

High expression of uracil DNA glycosylase determines C to T substitution in human pluripotent stem cells

Molecular Therapy: Nucleic Acids, 2022
Precise genome editing of human pluripotent stem cells (hPSCs) is crucial not only for basic science but also for biomedical applications such as ex vivo stem cell therapy and genetic disease modeling.
Ju-Chan Park, Hyeon-Ki Jang, Jumee Kim, Jun Hee Han, Youngri Jung, Keuntae Kim, Sangsu Bae, Hyuk-Jin Cha   +7 more
doaj   +1 more source

Redox-dependent control of i-Motif DNA structure using copper cations [PDF]

, 2018
Previous computational studies have shown that Cu+ can act as a substitute for H+ to support formation of cytosine (C) dimers with similar conformation to the hemi-protonated base pair found in i-motif DNA.
Abraham, Alberti, Andrew J Gates, Benabou, Chen, Choi, Choi, Colin J MacDonald, Dai, Day, Day, Dhakal, Dong, Gao, Gehring, Gurung, Hanwell, Jhaveri, Jorgensen, Kim, Krepl, Kypr, Li, Liang, Lieblein, Liu, Liu, László Fábián, Mahmoud AS Abdelhamid, McKim, Mergny, Mergny, Mergny, Modi, MOPAC2016, Myles R Cheesman, Phan, Phan, Smith, Valiev, Wang, Wright, Yuan, Zgarbová, Zgarbová, Zoë AE Waller, Řezáč   +46 more
core   +1 more source