Results 181 to 190 of about 42,535 (254)

Mutagenicity and Repair of Acrolein Adduct to Cytosine. [PDF]

Int J Mol Sci
Dylewska M, Kasperowicz S, Sokołowska B, Maciejewska AM.   +3 more
europepmc   +1 more source

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
wiley   +1 more source

Assessing the feasibility of machine learning for ancient DNA age prediction: Limitations and insights. [PDF]

Biol Methods Protoc
Kazanskii M, Golikova M, Kasianov A, Ivanova A, Suraganov A, Uroshlev L.   +5 more
europepmc   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Cellular and Molecular Mechanisms of Oxidative DNA Damage and Repair. [PDF]

Medicina (Kaunas)
Ayna A, Caglayan C, Taysi S.
europepmc   +1 more source

Metabolic Signatures of Aging and Gametogenesis in Hydra oligactis

Aging Cell, Volume 25, Issue 8, August 2026.
Hydra oligactis undergoes cold‐induced sexual differentiation and aging, culminating in death. GC–MS‐based metabolite profiling revealed signatures of gametogenesis, for example, polyamine accumulation, and of aging, such as loss of cytoprotection and neurotransmitter function, including taurine depletion.
Nicki Marami‐Zonouz, Erwann Arc, Thomas Roach, Pidder Jansen‐Dürr, Werner Bader, Bert Hobmayer, Ilse Kranner   +6 more
wiley   +1 more source

Genome sequence of influenza virus strain A/Ust-Kamenogorsk/972/2023 (H3N2) from Kazakhstan. [PDF]

Microbiol Resour Announc
Ongarbayeva N, Glebova T, Klivleyeva N, Saktaganov N, Baimukhametova A, Kalkozhayeva M, Lukmanova G, Karamendin K.   +7 more
europepmc   +1 more source

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, Volume 183, Issue 16, Page 4735-4760, August 2026.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source

Mitochondrial genome microhomology-mediated editing by donor DNA delivery into mitochondria in human cells. [PDF]

Mol Ther Nucleic Acids
Maximov VV, Shebanov N, Nikitchina N, Rapoport R, Maor Y, Tarassov I, Pines O, Entelis N.   +7 more
europepmc   +1 more source

Alkylation of cytosine glycosides in alkaline medium: a new route to the preparation of O'-alkylated nucleosides and nucleotides of cytosine and uracil.

Acta biochimica Polonica, 1972
J T, Kuśmierek, D, Shugar
openaire   +1 more source