Results 171 to 180 of about 42,535 (254)

Correlation of the peripheral blood DNA methylation profile and immune‐related adverse events in patients with solid cancer treated with immune checkpoint inhibitors

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Baseline blood DNA methylation profiles predict early immune‐related adverse events across cancer types. A methylation‐based classifier demonstrated robust discriminatory performance and revealed enrichment of neuronal and developmental regulatory pathways, suggesting a systemic epigenetic predisposition to immune toxicity following immune checkpoint ...
Markus Kleinberger, Angelika Martina Starzer, Erwin Tomasich, Julia Maria Berger, Vincent Sunder‐Plassmann, Lynn Gottmann, Isabella Solano Henao, Martin Korpan, Josef Fuerst, Nikola Vladic, Cihan Ay, Helmuth Haslacher, Julia Furtner, Matthias Preusser, Gerwin Heller, Anna Sophie Berghoff   +15 more
wiley   +1 more source

Mitogenomics of Culex pipiens Form Pipiens From the Turkish Black Sea Region Reveals Structural Conservation and Phylogenetic Complexity

Ecology and Evolution, Volume 16, Issue 8, August 2026.
Complete mitochondrial genomes of five Turkish Culex pipiens form pipiens isolates from the Black Sea region revealed highly conserved mitogenome architecture. Expanded comparisons across the broader Cx. pipiens complex showed that mitochondrial diversity was concentrated in selected loci and terminal regions associated with the A + T‐rich control ...
Ahsen Meliha Toroslu, Alparslan Yildirim, Gokmen Zafer Pekmezci, Osman Ibis, Samba Deguene Diop, Batuhan Askim Arslanhan, Saffet Teber, Alina Denis Kizgin, Simge Sahin, Filiz Gunay, Nathan Burkett‐Cadena, Lindsay Campbell, Abdullah Inci, Barry Wilmer Alto   +13 more
wiley   +1 more source

Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes. [PDF]

Proc Natl Acad Sci U S A
Ramos-Almodóvar F, Gao Z, Voight BF, Mathieson I.   +3 more
europepmc   +1 more source

Effects of Exogenous Monosodium Glutamate on GABA Accumulation and Volatile/Nonvolatile Metabolites in Black Highland Barley

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Overview of MSG‐assisted GABA enrichment and associated changes in amino acid, fatty acid, and volatile metabolite profiles in germinated black highland barley. ABSTRACT γ‐Aminobutyric acid (GABA) is a functional amino acid with multiple health benefits; however, the mechanism of its enrichment in black highland barley, particularly through precursor ...
Xiaohang Lu, Nana Ma, Yuan Wang
wiley   +1 more source

PolyA tail segmentation improves the stability of the template DNA and increases the translatability of in vitro transcribed mRNA. [PDF]

Nucleic Acids Res
Spiewla T, Czubak K, Pilch Z, Baranowski MR, Krawczyk PS, Affek K, Antczak W, Szulc-Gasiorowska M, Chmielinski S, Mroczek S, Brouze M, Nowis D, Golab J, Dziembowski A, Jemielity J, Kowalska J.   +15 more
europepmc   +1 more source

Epigenetic and Brain Structure Covariation Patterns in Typical and Atypical Development

Human Brain Mapping, Volume 47, Issue 11, 01 August 2026.
We present a map linking DNA methylation to brain structure in childhood. Genes in which methylation was linked to brain anatomy are highly enriched for those implicated in psychiatric and neurodevelopmental disorders, highlighting potential epigenetic targets for understanding both typical and atypical brain development.
Valentine Chirokoff, Jo Wrigglesworth, Peter Daniel Fransquet, Yen Ting Wong, Jeffrey M. Craig, Tim J. Silk   +5 more
wiley   +1 more source

Alkyltransferase Ribozyme for Site-Specific N⁴-Cytidine Alkylation. [PDF]

Angew Chem Int Ed Engl
Dorinova E, Walunj MB, Höbartner C.
europepmc   +1 more source

Passenger variants as pan‐clonal markers of pediatric AML: Implications for molecular MRD

HemaSphere, Volume 10, Issue 8, August 2026.
Abstract A streamlined, sensitive, and universal molecular method for MRD detection in pediatric AML remains an unmet clinical need. Here, we propose a novel approach based on tracking somatic non‐coding passenger variants. Using whole‐genome sequencing (WGS) of diagnostic bone marrow DNA, we identify patient‐specific somatic passenger variants, which ...
Ruth Shiloh, Dana Dayan, Ifat Geron, Maor Cohen, Tamar Feuerstein, Jorge Cano‐Nistal, Nurit Gal‐Mark, Shlomit Barzilai‐Birenboim, Dafna Gaash, Michal Hameiri‐Grossman, Avraham Kahan, Jamal Mahajna, Nino Oniashvili, Hava Rosenfeld, Dan Scharf, Keren Shichrur, Elena Shinderman‐Maman, Sarah Elitzur, Yehudit Birger, Shai Izraeli, Yosef E. Maruvka   +20 more
wiley   +1 more source

Methylation of DNA duplexes regulates cGAS-mediated innate immune activation <i>via</i> condensate formation. [PDF]

RSC Chem Biol
Morihiro K, Baba M, Yamada M, Okamoto A.
europepmc   +1 more source

Keratan Sulfate: An Electroconductive Glycosaminoglycan at the Interface of Sensory Perception and Neural Signaling

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Laboratory studies show KS has electroconductive properties with the ability to trap and transport protons in neurotransductive processes (Grotthuss proton shuttling). This maintains electrochemical gradients and fluxes at the neuronal cell surface in neural activation. Such processes are central to neuronal cell signaling and communication.
James Melrose
wiley   +1 more source