Results 241 to 250 of about 196,328 (291)

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

The Human Lens Fiber Cytoskeletome Reveals Neuronal Signatures and the Presence of Chaperonins, Proteasome, Signaling, and Redox Regulators. [PDF]

Invest Ophthalmol Vis Sci
Maddala R, Lankford LK, Skiba NP, Rao PV.   +3 more
europepmc   +1 more source

Dynamic Self‐Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration

Advanced Science, EarlyView.
Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong, Tuba Marjan, Ngoc Ha Luong, Taimoor H. Qazi, Chien‐Chi Lin   +4 more
wiley   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Dual targeting of mitochondrial metabolism and Rho GTPase signaling to suppress cancer metastasis (Review). [PDF]

Oncol Rep
Daher A, Assi Z, Kanaan A, Al Khatib A, El Sibai M.   +4 more
europepmc   +1 more source

Research progress on the interaction mechanisms and functions between exosomes and the cytoskeleton. [PDF]

Front Cell Dev Biol
Yang S, Zhang X, Chen B, Kou H, Lai L, Liu H, Xu Y, Sun Y.   +7 more
europepmc   +1 more source

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Turnover of cytoskeletal proteins in vivo

Brain Research, 1990
The turnover of the microtubule-associated proteins 1B and 2 (MAP1B and MAP2), tubulin, high molecular weight neurofilament protein (NF-H), and spectrin were studied by in vivo labeling. Radiolabeled [35S]methionine was injected intracranially to 10-day-old rats and the rate of turnover was measured for total and specific brain proteins.
R, Safaei, I, Fischer
openaire   +2 more sources

Progesterone Receptor or Cytoskeletal Protein?

Reproductive Sciences, 2007
Immunoblotting is used to characterize the various nuclear progesterone receptor (nPR) isoforms present in tissues; however, the success of this technique is dependent on the specificity of the primary nPR antibody. The authors investigate the specificity of a frequently used nPR antibody, sc-538, in total protein from human myometrium and a myometrial
Gemma, Madsen, David A, Macintyre, Sam, Mesiano, Roger, Smith   +3 more
openaire   +2 more sources

Cytoskeletal proteins and Golgi dynamics

Current Opinion in Cell Biology, 1998
Association of the Golgi complex with cytoskeletal elements, in particular microtubules, is required for maintenance of the Golgi's characteristic spatial location within cells and for efficient delivery of proteins and lipids to diverse cellular sites.
openaire   +2 more sources

The role of cytoskeletal proteins in cardiomyopathies

Current Opinion in Cell Biology, 1998
Cardiomyopathies are serious heart muscle disorders in children and adults, which result in morbidity and premature death. These disorders include hypertrophic cardiomyopathy, dilated cardiomyopathy and restrictive cardiomyopathy. Recently, mutations in seven genes, all encoding sarcomeric proteins, have been identified as causes of familial ...
openaire   +2 more sources