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FH proteins as cytoskeletal organizers
Trends in Cell Biology, 1998Regulation of cell shape is a poorly understood yet central issue in cell biology. Recent experiments indicate that FH proteins link cellular signalling pathways to changes in cell shape. Members of the FH protein family play essential roles in cytokinesis and in driving alterations in cell polarity.
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Radixin: cytoskeletal adopter and signaling protein
The International Journal of Biochemistry & Cell Biology, 2004Radixin functions as a membrane-cytoskeletal crosslinkers in actin-rich cell surface structures and is thereby thought to be essential for cortical cytoskeleton organization, cell motility, adhesion and proliferation. This modular polypeptide consists of a long, central helix, termed the alpha-domain, which connects an N-terminal 4.1/ezrin/radixin ...
Klaus P, Hoeflich, Mitsuhiko, Ikura
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Purification of Tetrahymena Cytoskeletal Proteins
2012Like all eukaryotic cells, Tetrahymena thermophila contains a rich array of cytoskeletal proteins, some familiar and some novel. A detailed analysis of the structure, function, and interactions of these proteins requires procedures for purifying the individual protein components. Procedures for the purification of actin and tubulin from Tetrahymena are
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Role of the Cytoskeletal Protein Paxillin in Oncogenesis
Critical Reviews™ in Oncogenesis, 2000The focal adhesion is an important cellular structure that is involved in cell signaling, cell motility, and oncogenic transformation. Paxillin is a unique adapter protein that is localized to the focal adhesion and is involved in regulating various functions of the focal adhesion.
M, Sattler +3 more
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Cytoskeletal functions of cytoplasmic contractile proteins
Journal of Supramolecular Structure, 1976AbstractThis is a review of the evidence that the cytoplasmic contractile proteins function as a cytoskeletal system inthe cytoplasmic matrix. Biochemical experiments show that cycoplasmic actin filaments can form a solid gel under conditions likely to exist in living cells. The actin filaments are associated with other proteins which may stabilize the
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TDP-43 and Cytoskeletal Proteins in ALS
Molecular Neurobiology, 2017Amyotrophic lateral sclerosis (ALS) represents a rapidly progressing neurodegenerative disease and is characterized by a degeneration of motor neurons. Motor neurons are particularly susceptible to selective and early degeneration because of their extended axon length and their dependency on the cytoskeleton for its stability, signaling, and axonal ...
Moritz, Oberstadt +3 more
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Interaction of Cytoskeletal Proteins with Membrane Lipids
1997Rapid and significant progress has been made in understanding lipid/protein interactions involving cytoskeletal components and the plasma membrane. Covalent and noncovalent lipid modifications of cytoskeletal proteins mediate their interaction with lipid bilayers.
G, Isenberg, V, Niggli
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Glial shape and cytoskeletal protein synthesis
Neurochemical Research, 1992We investigated whether the shape of astroglial derived cells influences the expression of cytoskeletal proteins. In reaggregating cultures GFAP, vimentin and actin synthesis was approximately 52%, 50% and 37% the level found in monolayer cultures, respectively.
J P, Bressler, N A, Edwards
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Cytoskeletal and adhesion proteins as tumor suppressors
Current Opinion in Cell Biology, 1997In the past year, significant progress has been made in the attempt to understand the molecular mechanisms underlying signaling that is induced by cell-cell and cell-extracellular-matrix adhesion and that involves the cytoskeleton. In particular, molecules of the cytoplasmic plaques of cell-cell junctions have been shown to complex with transcription ...
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Cytoskeletal protein abnormalities in neurodegenerative diseases
Annals of Neurology, 1986AbstractThe nervous system is a rich source of filamentous proteins that assume critical roles in determining and maintaining neuronal form and function. Neurons contain three major classes of these cytoskeletal organelles: microtubules, intermediate filaments, and microfilaments.
J E, Goldman, S H, Yen
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