Results 61 to 70 of about 5,939,536 (365)

Crosstalk between Mitochondria and Cytoskeleton in Cardiac Cells

Cells, 2020
Elucidation of the mitochondrial regulatory mechanisms for the understanding of muscle bioenergetics and the role of mitochondria is a fundamental problem in cellular physiology and pathophysiology. The cytoskeleton (microtubules, intermediate filaments,
Andrey V. Kuznetsov, Sabzali Javadov, Michael Grimm, Raimund Margreiter, Michael J. Ausserlechner, Judith Hagenbuchner   +5 more
doaj   +1 more source

The minimal structure containing the band 3 anion transport site. A 35Cl NMR study [PDF]

, 1985
35Cl NMR, which enables observation of chloride binding to the anion transport site on band 3, is used in the present study to determine the minimal structure containing the intact transport site.
Chan, Sunney I., Falke, Joseph J., Kanes, Katherine J.   +2 more
core  

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies [PDF]

, 2016
Acknowledgments This work was supported by The Croatian Science Foundation grant No. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Babić Leko, Mirjana, Bažadona, Danira, Buée, Luc, de Silva, Rohan, Delalle, Ivana, Giovanni, Giuseppe Di, Harrington, Charles, Hof, Patrick R., Jovanov-Milošević, Nataša, Wischik, Claude, Wray, Selina, Šimić, Goran   +11 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro.

PLoS ONE, 2012
IQGAP1 is a scaffold protein that interacts with proteins of the cytoskeleton and the intercellular adhesion complex. In podocytes, IQGAP1 is associated with nephrin in the glomerular slit diaphragm (SD) complex, but its role remains ill-defined. In this
Claire Rigothier, Patrick Auguste, Gavin I Welsh, Sébastien Lepreux, Colette Deminière, Peter W Mathieson, Moin A Saleem, Jean Ripoche, Christian Combe   +8 more
doaj   +1 more source

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion [PDF]

, 2017
The most lethal form of malaria in humans is caused by Plasmodium falciparum. These parasites invade erythrocytes, a complex process involving multiple ligand-receptor interactions.
Cowman, Alan, Fleig, Andrea, Horgen, F. David, Malpede, Brian M, Nebl, Thomas, O\u27Neill, Joseph, Rogers, Kelly, Salinas, Nichole D, Sisquella, Xavier, Tham, Wai-Hong, Thompson, Jennifer K, Tolia, Niraj H, Whitehead, Lachlan   +12 more
core   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Cold-induced denaturation of muscle proteins in hairtail (Trichiurus lepturus) during storage: Physicochemical and label-free based proteomics analyses

Food Chemistry: X, 2022
Physicochemical, proteomics, and bioinformatics analyses were conducted to investigate protein profiles in Trichiurus haumela under frozen (120 d) and chilled (6 d) storage.
Shanshan Shui, Hongbo Yan, Chuanhai Tu, Soottawat Benjakul, Santiago P. Aubourg, Bin Zhang   +5 more
doaj   +1 more source

Identification of Molecular Switch Regulating Interactions of Janus Kinase 3 with Cytoskeletal Proteins*

Journal of Biological Chemistry, 2012
Background: Jak3 is a tyrosine kinase, and the mechanism of Jak3 interactions with cytoskeletal proteins is not known. Results: Tyrosine autophosphorylation of SH2 domain of Jak3 facilitated the interactions between the Jak3-FERM domain and cytoskeletal ...
Jayshree Mishra, S. S. Karanki, Narendra Kumar   +2 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source