Results 41 to 50 of about 196,328 (291)

Novel keratins identified by quantitative proteomic analysis as the major cytoskeletal proteins of equine (Equus caballus) hoof lamellar tissue

, 2010
The dermo-epidermal interface that connects the equine distal phalanx to the cornified hoof wall withstands great biomechanical demands, but is also a region where structural failure often ensues as a result of laminitis.
R. A. Carter, Shekk, V., Galantino-Homer, H.L., M. A. de Laat, Pollitt, C.C., V. Shekk, Carter, R.A., C. C. Pollitt, de Laat, M.A., H. L. Galantino-Homer   +9 more
core   +1 more source

Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario

Disease Models & Mechanisms, 2017
Alzheimer's disease (AD) manifests as neuronal loss. On the premise of Grb2 overexpression in AD mouse brain and brain tissues of AD patients, our study primarily focuses on the stability of cytoskeletal proteins in the context of degenerative AD-like ...
Piyali Majumder, Kasturi Roy, Brijesh Kumar Singh, Nihar Ranjan Jana, Debashis Mukhopadhyay   +4 more
doaj   +1 more source

The role of the cortical cytoskeleton [PDF]

, 1996
We generated Dictyostelium double mutants lacking the two F-actin crosslinking proteins alpha-actinin and gelation factor by inactivating the corresponding genes via homologous recombination.
Schleicher, Michael, Albrecht, Richard, Rivero, Francisco, Peracino, Barbara, Noegel, Angelika A., Köppel, Bernd, Siegert, Florian, Bozzaro, Salvatore, Weijer, Cornelis J.   +8 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Shigella flexneri utilize the spectrin cytoskeleton during invasion and comet tail generation

BMC Microbiology, 2012
Background The spectrin cytoskeleton is emerging as an important host cell target of enteric bacterial pathogens. Recent studies have identified a crucial role for spectrin and its associated proteins during key pathogenic processes of Listeria ...
Ruetz Tyson J, Lin Ann E, Guttman Julian A   +2 more
doaj   +1 more source

Glucocorticoids Preferentially Influence Expression of Nucleoskeletal Actin Network and Cell Adhesive Proteins in Human Trabecular Meshwork Cells

Frontiers in Cell and Developmental Biology, 2022
Clinical use of glucocorticoids is associated with increased intraocular pressure (IOP), a major risk factor for glaucoma. Glucocorticoids have been reported to induce changes in actin cytoskeletal organization, cell adhesion, extracellular matrix ...
William Bachman, Rupalatha Maddala, Ayon Chakraborty, Camelia Eldawy, Nikolai P. Skiba, Ponugoti V. Rao, Ponugoti V. Rao   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Quantifying cytoskeletal protein interactions with far Western blotting

Frontiers in Molecular Biosciences
The study of cytoskeletal proteins has been limited by some of their intrinsic properties, such as fixed intracellular localization and insolubility, which limit the implementation of many protein–protein interaction assays.
Marcelo M. Melo, Elizabeth S. Phillippi, Mark L. Schultz, Susan Q. Shen, Hatem El-Shanti   +4 more
doaj   +1 more source

Neural stem cells over-expressing brain-derived neurotrophic factor promote neuronal survival and cytoskeletal protein expression in traumatic brain injury sites

Neural Regeneration Research, 2017
Cytoskeletal proteins are involved in neuronal survival. Brain-derived neurotrophic factor can increase expression of cytoskeletal proteins during regeneration after axonal injury.
Tao Chen, Yan Yu, Liu-jiu Tang, Li Kong, Cheng-hong Zhang, Hai-ying Chu, Liang-wei Yin, Hai-ying Ma   +7 more
doaj   +1 more source

Crosstalk between Mitochondria and Cytoskeleton in Cardiac Cells

Cells, 2020
Elucidation of the mitochondrial regulatory mechanisms for the understanding of muscle bioenergetics and the role of mitochondria is a fundamental problem in cellular physiology and pathophysiology. The cytoskeleton (microtubules, intermediate filaments,
Andrey V. Kuznetsov, Sabzali Javadov, Michael Grimm, Raimund Margreiter, Michael J. Ausserlechner, Judith Hagenbuchner   +5 more
doaj   +1 more source