Cell Reports, 2023 Summary: Appropriate cytoskeletal organization is essential for vascular smooth muscle cell (VSMC) conditions such as hypertension. This study identifies FXR1 as a key protein linking cytoskeletal dynamics with mRNA stability.
Amanda St. Paul +8 more
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Cytoskeletal Expression and Remodeling in Pluripotent Stem Cells. [PDF]
PLoS ONE, 2016 Many emerging cell-based therapies are based on pluripotent stem cells, though complete understanding of the properties of these cells is lacking. In these cells, much is still unknown about the cytoskeletal network, which governs the mechanoresponse ...
Liana C Boraas +3 more
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Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms [PDF]
, 2005 Integrins are adhesion receptors that are crucial to the functions of multicellular organisms. Integrin-mediated adhesion is a complex process that involves both affinity regulation and cytoskeletal coupling, but the molecular mechanisms behind this ...
Susanna C. Fagerholm +11 more
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RBC-NOS-dependent S-nitrosylation of cytoskeletal proteins improves RBC deformability. [PDF]
PLoS ONE, 2013 BACKGROUND: Red blood cells (RBC) possess a nitric oxide synthase (RBC-NOS) whose activation depends on the PI3-kinase/Akt kinase pathway. RBC-NOS-produced NO exhibits important biological functions like maintaining RBC deformability.
Marijke Grau +6 more
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Modulation of Phosducin-Like Protein 3 (PhLP3) Levels Promotes Cytoskeletal Remodelling in a MAPK and RhoA-Dependent Manner [PDF]
, 2011 Background Phosducin-like protein 3 (PhLP3) forms a ternary complex with the ATP-dependent molecular chaperone CCT and its folding client tubulin. In vitro studies suggest PhLP3 plays an inhibitory role in ?-tubulin folding while conversely in vivo ...
C Mark Smales +14 more
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The Emerging Role of the Cytoskeleton in Chromosome Dynamics
Frontiers in Genetics, 2017 Chromosomes underlie a dynamic organization that fulfills functional roles in processes like transcription, DNA repair, nuclear envelope stability, and cell division.
Maya Spichal, Emmanuelle Fabre
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SILAC-based proteomic quantification of chemoattractant-induced cytoskeleton dynamics on a second to minute timescale [PDF]
, 2014 Cytoskeletal dynamics during cell behaviours ranging from endocytosis and exocytosis to cell division and movement is controlled by a complex network of signalling pathways, the full details of which are as yet unresolved.
Sobczyk, Grzegorz J. +2 more
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PLoS ONE, 2013 Myofibroblasts, specialized cells that play important roles in wound healing and fibrosis, can develop from epithelial cells through an epithelial-mesenchymal transition (EMT).
Joseph W O'Connor, Esther W Gomez
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Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability
Scientific Reports, 2020 Muscle wasting and atrophy are regulated by multiple molecular processes, including mRNA processing. Reduced levels of the polyadenylation binding protein nucleus 1 (PABPN1), a multifactorial regulator of mRNA processing, cause muscle atrophy.
Cyriel Sebastiaan Olie +10 more
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The apical submembrane cytoskeleton participates in the organization of the apical pole in epithelial cells [PDF]
, 1997 In a previous publication (Rodriguez, M.L., M. Brignoni, and P.J.I. Salas. 1994. J. Cell Sci. 107: 3145-3151), we described the existence of a terminal web-like structure in nonbrush border cells, which comprises a specifically apical cytokeratin ...
Ana L. Viciana +14 more
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