RBC-NOS-dependent S-nitrosylation of cytoskeletal proteins improves RBC deformability. [PDF]
PLoS ONE, 2013 BACKGROUND: Red blood cells (RBC) possess a nitric oxide synthase (RBC-NOS) whose activation depends on the PI3-kinase/Akt kinase pathway. RBC-NOS-produced NO exhibits important biological functions like maintaining RBC deformability.
Marijke Grau +6 more
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Modulation of Phosducin-Like Protein 3 (PhLP3) Levels Promotes Cytoskeletal Remodelling in a MAPK and RhoA-Dependent Manner [PDF]
, 2011 Background Phosducin-like protein 3 (PhLP3) forms a ternary complex with the ATP-dependent molecular chaperone CCT and its folding client tubulin. In vitro studies suggest PhLP3 plays an inhibitory role in ?-tubulin folding while conversely in vivo ...
C Mark Smales +14 more
core +1 more source
The Emerging Role of the Cytoskeleton in Chromosome Dynamics
Frontiers in Genetics, 2017 Chromosomes underlie a dynamic organization that fulfills functional roles in processes like transcription, DNA repair, nuclear envelope stability, and cell division.
Maya Spichal, Emmanuelle Fabre
doaj +1 more source
Novel keratins identified by quantitative proteomic analysis as the major cytoskeletal proteins of equine (Equus caballus) hoof lamellar tissue [PDF]
, 2010 The dermo-epidermal interface that connects the equine distal phalanx to the cornified hoof wall withstands great biomechanical demands, but is also a region where structural failure often ensues as a result of laminitis.
R. A. Carter +9 more
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SILAC-based proteomic quantification of chemoattractant-induced cytoskeleton dynamics on a second to minute timescale [PDF]
, 2014 Cytoskeletal dynamics during cell behaviours ranging from endocytosis and exocytosis to cell division and movement is controlled by a complex network of signalling pathways, the full details of which are as yet unresolved.
Sobczyk, Grzegorz J. +2 more
core +1 more source
PLoS ONE, 2013 Myofibroblasts, specialized cells that play important roles in wound healing and fibrosis, can develop from epithelial cells through an epithelial-mesenchymal transition (EMT).
Joseph W O'Connor, Esther W Gomez
doaj +1 more source
Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability
Scientific Reports, 2020 Muscle wasting and atrophy are regulated by multiple molecular processes, including mRNA processing. Reduced levels of the polyadenylation binding protein nucleus 1 (PABPN1), a multifactorial regulator of mRNA processing, cause muscle atrophy.
Cyriel Sebastiaan Olie +10 more
doaj +1 more source
The apical submembrane cytoskeleton participates in the organization of the apical pole in epithelial cells [PDF]
, 1997 In a previous publication (Rodriguez, M.L., M. Brignoni, and P.J.I. Salas. 1994. J. Cell Sci. 107: 3145-3151), we described the existence of a terminal web-like structure in nonbrush border cells, which comprises a specifically apical cytokeratin ...
Ana L. Viciana +14 more
core +1 more source
New Frontiers for the Cytoskeletal Protein LASP1 [PDF]
Frontiers in Oncology, 2018 In the recent two decades, LIM and SH3 protein 1 (LASP1) has been developed from a simple actin-binding structural protein to a tumor biomarker and subsequently to a complex, nuclear transcriptional regulator. Starting with a brief historical perspective, this review will mainly compare and contrast LASP1 and LASP2 from the angle of the newest data and
Butt, Elke, Raman, Dayanidhi
openaire +4 more sources
Cytoskeletal proteins and resident flora [PDF]
, 2002 Recent observations demonstrate that enteropathogenetic and enterohaemorrhagic bacteria, as well as other non enteropathogenetic bacteria (Listeria, Coxiella Burnetii), may subvert the host cell cytoskeleton.
PALLONE, FRANCESCO +16 more
core +1 more source