Results 61 to 70 of about 489,558 (321)

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Deregulated expression of cytoskeleton related genes in the spinal cord and sciatic nerve of presymptomatic SOD1G93A Amyotrophic Lateral Sclerosis mouse model

Frontiers in Cellular Neuroscience, 2014
Early molecular events related to cytoskeleton are poorly described in Amyotrophic Lateral Sclerosis (ALS), especially in the Schwann cell (SC), which offers strong trophic support to motor neurons.
Jessica Ruivo Maximino, Gabriela Pintar de Oliveira, Chrystian Junqueira Alves, Gerson eChadi   +3 more
doaj   +1 more source

Action potential-coupled Rho GTPase signaling drives presynaptic plasticity

eLife, 2021
In contrast to their postsynaptic counterparts, the contributions of activity-dependent cytoskeletal signaling to presynaptic plasticity remain controversial and poorly understood.
Shataakshi Dube O'Neil, Bence Rácz, Walter Evan Brown, Yudong Gao, Erik J Soderblom, Ryohei Yasuda, Scott H Soderling   +6 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

SSNA1 stabilizes dynamic microtubules and detects microtubule damage

eLife, 2021
Sjögren’s syndrome nuclear autoantigen-1 (SSNA1/NA14) is a microtubule-associated protein with important functions in cilia, dividing cells, and developing neurons. However, the direct effects of SSNA1 on microtubules are not known.
Elizabeth J Lawrence, Goker Arpag, Cayetana Arnaiz, Marija Zanic   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Force balance and membrane shedding at the Red Blood Cell surface

, 2006
During the aging of the red-blood cell, or under conditions of extreme echinocytosis, membrane is shed from the cell plasma membrane in the form of nano-vesicles.
D. E. Discher, J. M. Werre, L. Backman, N. G. Van Kampen, Nir Gov, Pierre Sens, R. Bucki, R. E. Waugh, S. Levin, S.-C. Liu, S. P. Sutera, V. Bennett, W. H. Reinhart, Z. Tochner   +13 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Reversibility of Red blood Cell deformation

, 2011
The ability of cells to undergo reversible shape changes is often crucial to their survival. For Red Blood Cells (RBCs), irreversible alteration of the cell shape and flexibility often causes anemia.
C. T. Noguchi, G. Lim, H. Goldstein, L. D. Landau, Maria Zeitz, P. Sens   +5 more
core   +1 more source

The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer [PDF]

, 2014
The contractile actin-myosin cytoskeleton provides much of the force required for numerous cellular activities such as motility, adhesion, cytokinesis and changes in morphology.
AP Somlyo, B Rafn, C Gaggioli, C Gally, CL Moncrieff, CS Loo, D Pyeon, DA Heerding, DM Pirone, DR Rhodes, ER Gomes, ET Kimchi, F Corpet, G Brunhofer, G Groeger, H Yamaguchi, HI Lowe, I Tan, I Tan, I Tan, I Tan, I Tan, J Schlingemann, J Schwarz, JM Elkins, JM Herbert, K Ando, K Lefort, KE Fisher, L Huo, L Luo, LJ Veer van’t, LR Pearce, LT Lam, M Jacobs, M Uehata, M Vicente-Manzanares, MA Fabian, MA Ginos, Mathieu Unbekandt, MF Olson, MF Olson, Michael F. Olson, N Nakamura, N Rath, P Basu, P Madaule, PL Podolin, R Cmejla, RW Scott, S Balasenthil, S Wang, S Wilkinson, S Yamamoto, SH Choi, SM Kim, T Heikkila, T Leung, T Sumi, X Liu, Y Hao, Y Ng, Y Zhao   +62 more
core   +1 more source