Results 241 to 250 of about 256,621 (293)

Extrapolation of lung pharmacokinetics of bedaquiline across species using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Aims BeBedaquiline (BDQ) is a first‐in‐class diarylquinoline (DARQ) and a potent anti‐tuberculosis drug, vital in combating multi‐drug resistant tuberculosis (TB). Understanding its lung pharmacokinetics (PK) across species is crucial for effective clinical translation.
Evangelos Karakitsios, Oscar Della Pasqua, Aristides Dokoumetzidis   +2 more
wiley   +1 more source

Physics of Protein Aggregation in Normal and Accelerated Brain Aging

BioEssays, EarlyView.
Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age‐related exposures (e.g., microbes, nanoparticles). Persistent soluble‐to‐insoluble phase transition depletes the functional proteins. In normal aging, replacement matches loss; in accelerated aging, it does not.
Alberto J. Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady Williamson, Kora Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanovic, Fredric P. Manfredsson   +9 more
wiley   +1 more source

Influenza A virus RNA localisation and the interceding trafficking pathways of the host cell. [PDF]

PLoS Pathog
Bonazza S, Courtney DG.
europepmc   +1 more source

Artificial intelligence‐assisted design, synthesis and analysis of smart biomaterials

BMEMat, EarlyView.
Smart biomaterials are rapidly emerging as tools for tissue engineering, and artificial intelligence has played essential roles in biomaterial studies. By bridging the literature gap in AI‐based design, synthesis and analysis of smart biomaterials, the current review shares perspectives on how biomaterial scientists can practically incorporate AI for ...
Pengfei Jiang, Yefei Dai, Yujun Hou, Joshua Stein, Shichen Steven Lin, Chaochen Zhou, Yannan Hou, Rongrong Zhu, Ki‐Bum Lee, Letao Yang   +9 more
wiley   +1 more source

Dielectric Responses of Cytosolic Water Change with Aging of Circulating Red Blood Cells. [PDF]

Cells
Latypova L, Galindo C, Livshits L, Teope RV, Arbell D, Barshtein G, Bogdanova A, Feldman Y.   +7 more
europepmc   +1 more source

Enhancement of D‐mannitol production by fine‐tuned expression of mannitol‐1‐phosphate dehydrogenase in Synechocystis sp. PCC6803

Biotechnology Progress, EarlyView.
Abstract D‐Mannitol production was achieved in freshwater Synechocystis sp. PCC6803 via the heterologous expression of mannitol‐1‐phosphate dehydrogenase (mtlD) and mannitol‐1‐phosphatase (m1p) under control of the strong promoter Ptrc1. However, only 5.54 mg L−1 of mannitol was found extracellularly after 7 days of cultivation, likely due to ...
Wenyang Wu, Wei Du, Klaas J. Hellingwerf, Filipe dos Branco dos Santos   +3 more
wiley   +1 more source

Alpha-Synuclein Phosphomimetic Y39E and S129D Knock-In Mice Show Cytosolic Alpha-Synuclein Localization without Developing Neurodegeneration or Motor Deficits. [PDF]

eNeuro
Kim Y, Vaidya B, McInnes J, Zoghbi HY.
europepmc   +1 more source

Lupeol‐Loaded Liposomes: Triple‐Negative Breast Cancer (TNBC) Cytotoxicity and In Vivo Toxicological Evaluation

Chemistry &Biodiversity, EarlyView.
ABSTRACT Lupeol is a natural product commonly found in many vegetables and fruits in significant quantities. Previous studies have demonstrated the relevant activity of lupeol against various tumor cell lines, suggesting that the natural product could be a promising agent for cancer treatment.
Daniel Crístian Ferreira Soares, Daniel Bragança Viana, André Luis Branco de Barros, Sued Eustáquio Mendes Miranda, Daniela Sachs, Eduardo Henrique Martins Nunes, Eryvaldo Sócrates Tabosa do Egito   +6 more
wiley   +1 more source

Hydrogen peroxide, ascorbate, and glutathione: building the Foyer-Halliwell-Asada pathway. [PDF]

Planta
Noctor G.
europepmc   +1 more source

Peptidomimetics Targeting the Amyloidogenicity of Nucleophosmin 1 Mutations in Acute Myeloid Leukemia

ChemBioChem, EarlyView.
Previous studies reveal an unexpected tendency for amyloid aggregation in specific regions of the C‐terminal domain (CTD) of nucleophosmin 1 (NPM1), a nucleolar chaperone involved in acute myeloid leukemia (AML). Herein, several peptide analogs of NPM1264‐277 (amyloid core) with conservative substitutions are designed and evaluated through biophysical ...
Daniele Florio, Sara La Manna, Giada Raffaella Fiore, Valentina Roviello, Giuliano Castellano, Sossio Fabio Graziano, Anna Maria Malfitano, Daniela Marasco   +7 more
wiley   +1 more source