Results 241 to 250 of about 336,446 (348)

A Nonviral Neo‐Nucleocapsid for Cell‐Specific RNA Delivery Developed by Pseudo‐Cyclic Peptide Grafting and Directed Evolution

Angewandte Chemie, EarlyView.
Nonviral neo‐nucleocapsids developed from a repurposed bacterial protein cage, and macrocyclic peptide pharmacophores via protein‐protein ligation, bacteria‐based directed evolution, lasso‐grafting, and mammalian cell‐based directed evolution enabled cell specific RNA delivery.
Daiki Kanayama, Naohiro Terasaka, Kazuki Kato, Sae Okazaki, Hiroaki Suga   +4 more
wiley   +2 more sources

ABA receptor isoforms differently regulate stomatal movements and generation of reactive oxygen species in ABA signaling in Arabidopsis guard cells. [PDF]

Plant Cell Physiol
Yin Y, Hayashi Y, Sirajam M, Shaiek O, Munemasa S, Nakamura Y, Kinoshita T, Murata Y, Mori IC.   +8 more
europepmc   +1 more source

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

Proceedings of the National Academy of Sciences of the United States of America, 2010
D. Richardson, D. Lane, E. Becker, M. Huang, Megan Whitnall, Y. S. Rahmanto, A. Sheftel, P. Ponka   +7 more
semanticscholar   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Fibril Structure of Desiccation‐Protective Tardigrade Protein CAHS‐8

Angewandte Chemie, EarlyView.
We present the atomic structure of the fibril formed by an intrinsically disordered protein that has been shown to be responsible for remarkable environmental stress in tardigrades. X‐ray crystallography reveals a unique mechanism of fibril assembly whereby a single helix forms a stable, antiparallel coiled‐coil dimer, which then assembles into a ...
Anas Malki, Jean‐Marie Teulon, Emmi A. Mikkola, Damien Maurin, Jean‐Luc Pellequer, Max H. Nanao, Martin Blackledge   +6 more
wiley   +2 more sources

Cathepsin D Cytosol Content in Colorectal Cancer

The International Journal of Biological Markers, 1999
C. Villar, J.C. Rodríguez, P.F. Raigoso, J.L. García-Muñiz, E. Martínez, F. Vizoso   +5 more
doaj   +1 more source

Emerging Roles of De Novo Proline Biosynthesis in Human Diseases. [PDF]

FASEB Bioadv
Pei E, Ma J.
europepmc   +1 more source

Examination of eukaryotic chaperonin-mediated nascent chain folding in the cytosol: a photocrosslinking approach

, 2004
Stephanie A. Etchells
openalex   +1 more source

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

Contribution of particle-induced lysosome membrane permeabilization to NLRP3 inflammasome activation and mitochondrial ROS production. [PDF]

Toxicol Sci
Albright JM, Holian A.
europepmc   +1 more source