Results 91 to 100 of about 862,062 (313)

Induction of IL 2 receptor expression and cytotoxicity of thymocytes by stimulation with TCF1 [PDF]

, 1985
We investigated the role of T cell cytotoxicity inducing factor 1 (TCF1) in the induction of a cytotoxic T cell response. We found that help-deficient thymocyte cultures supplied with saturating amounts of purified IL 2 did not develop CTL in a 5-day ...
Diamantstein, T., Dröge, W., Falk, Werner, Kaltmann, B., Katzer, B., Krammer, P. H., Männel, D. N.   +6 more
core  

Synthesis and Cytotoxic Activity of Biphenylurea Derivatives Containing Indolin-2-one Moieties

Molecules, 2016
In our endeavor towards the development of potent anticancer agents, two different sets of biphenylurea-indolinone conjugates, 5a–s and 8a,b were synthesized.
Wagdy M. Eldehna, Mohamed Fares, Hany S. Ibrahim, Muhammad A. Alsherbiny, Mohamed H. Aly, Hazem A. Ghabbour, Hatem A. Abdel-Aziz   +6 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Fusion of Sendai virus with the target cell membrane is required for T cell cytotoxicity [PDF]

, 1978
INFECTION of mice with viruses can generate cytotoxic T lymphocytes (CTL) which show restricted specificity for target cell lysis. Specific lysis requires that the virus used to prime the target cells must be of the same type as that used to sensitise ...
A Munro, A Scheid, H Tozawa, JW Schrader, K Sugamura, M Homma, MARY-JANE GETHING, MICHAEL WATERFIELD, RM Zinkernagel, U Koszinowski, U Koszinowski, ULRICH KOSZINOWSKI, Y Hosaka   +12 more
core   +1 more source

Immunomodulatory Effects of Modified Colostrum, Whey, and Their Combination With Other Natural Products: Effects on Natural Killer Cells

Current Therapeutic Research
Objectives: Natural killer (NK) cells are important immune system effector cells providing innate defenses against intracellular infections, including viral infections, immune surveillance, and cancer immunoediting.
Xuesheng Han, MS, David Vollmer, MS, Xuefei Yan, MS, Yahong Zhang, MS, Mingfa Zang, MPVM, Chenfei Zhang, MS, Catherine M. Sherwin, MS, Elena Y. Enioutina, MS   +7 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Cytotoxic activity of Treponema denticola [PDF]

, 1996
published_or_final_versio
Hannam, PM, Leung, WK, McBride, BC, Uitto, V-J   +3 more
core  

Anti-CD20 Therapy Acts via FcγRIIIA to Diminish Responsiveness of Human Natural Killer Cells [PDF]

, 2015
Natural killer (NK) immune cells mediate antibody-dependent cellular cytotoxicity (ADCC) by aggregating FcγRIIIA/CD16, contributing significantly to the therapeutic effect of CD20 monoclonal antibodies (mAb).
Capuano, Cristina, Cimino, Giuseppe, Galandrini, Ricciarda, Molfetta, Rosa, Paolini, Rossella, Pighi, Chiara, Rago, Angela, Romanelli, Maddalena, Santoni, Angela   +8 more
core   +1 more source

Rapid synthesis of highly monodisperse AgSbS2 nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

Beilstein Journal of Nanotechnology
Nanocrystals (NCs) of silver antimony sulfide (AgSbS2) in the cubic phase were successfully synthesized using the hot-injection method. This study is the first to investigate the cytotoxic effects of these NCs on human breast adenocarcinoma (MCF-7 ...
Funda Ulusu, Adem Sarilmaz, Yakup Ulusu, Faruk Ozel, Mahmut Kus   +4 more
doaj   +1 more source

Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells

Hayati Journal of Biosciences, 2019
Cancer is the second cause of death after cardiovascular diseases in the world. Anticancer prevention used can cause undesirable things. Flavonoids are secondary metabolites derived from natural products that are useful for anticancer treatment.
Tati Herlina, Nayla Haraswati, Riza Apriani, Vicki Nishinarizki, Shabarni Gaffar, Unang Supratman   +5 more
doaj   +1 more source