Results 261 to 270 of about 602,582 (313)

Cytotoxic Activity of Amaryllidaceae Alkaloids

Planta Medica, 1995
25 Amaryllidaceae alkaloids belonging to different skeletal types were evaluated for their cytotoxic activity against one murine non-tumoral cell line (LMTK) and two human tumoral cell lines (Molt4 and HepG2) according to established protocols. Significant differences of activity related with the type of skeleton of the tested alkaloids could be ...
B, Weniger, L, Italiano, J P, Beck, J, Bastida, S, Bergoñon, C, Codina, A, Lobstein, R, Anton   +7 more
openaire   +2 more sources

Activation of NK cell cytotoxicity

Molecular Immunology, 2005
Natural killer (NK) cells are innate effector lymphocytes necessary for defence against stressed, microbe-infected, or malignant cells. NK cells kill target cells by either of two major mechanisms that require direct contact between NK cells and target cells.
Smyth, Mark J., Cretney, Erika, Kelly, Janice M., Westwood, Jennifer A., Street, Shayna E. A., Yagita, Hideo, Takeda, Kazuyoshi, van Dommelen, Serani L. H., Degli-Espostic, Mariapia A., Hayakawa, Yoshihiro   +9 more
openaire   +5 more sources

Cytotoxic activities of fish leucocytes

Fish & Shellfish Immunology, 2006
Like mammalian leucocytes, white blood cells of fish are able to kill altered (e.g. virus-infected) and foreign (allogeneic or xenogeneic) cells. The existence of natural killer (NK)-like and specific cytotoxic cells in fish was first shown using allogeneic and xenogeneic effector/target cell systems.
Uwe, Fischer, Katrin, Utke, Tomonori, Somamoto, Bernd, Köllner, Mitsuru, Ototake, Teruyuki, Nakanishi   +5 more
openaire   +2 more sources

Cytotoxic activity of Staphylococcus hyicus

Veterinary Microbiology, 1991
Culture supernatants from a number of Staphylococcus hyicus strains caused toxic effects to both murine fibroblast and porcine keratinocyte cells in culture. The extent of cytotoxicity was shown to differ between strains and may provide an indication of strain virulence. Purification of cytotoxic activity produced by S.
R P, Allaker, M, Whitlock, D H, Lloyd
openaire   +2 more sources

The cytolytic and cytotoxic activities of palytoxin

Toxicon, 2011
Palytoxin (PlTX) is one of the largest compound present in nature and, with its strong ability to modify the normal function of different biological systems, is also classified as one of the most potent biotoxins. Many alterations are triggered by PlTX, directly or indirectly related to its interaction with Na(+),K(+)-ATPase and the consequent ...
Mirella, Bellocci, Gian Luca, Sala, Simone, Prandi   +2 more
openaire   +2 more sources

The antiherpesvirus activity and cytotoxicity of sangivamycin

Current Eye Research, 1987
Sangivamycin, 4-amino-5-carboxamido-7-(beta-D-ribofuranosyl)-pyrrolo[2,3-d]-pyrimidine is a structural analog of adenosine belonging to a group of nucleosides classified as pyrrolopyrimidines. Sangivamycin, an adenosine deaminase resistant analog, was found to inhibit the replication of three strains of herpes simplex virus type 1 (HSV-1) by 50% (ED50)
W J, O'Brien, J L, Taylor, T P, O'Malley, P S, Ritch   +3 more
openaire   +2 more sources

Targeting and Activation of Cytotoxic Lymphocytes

2015
Des anticorps heteroconjugues ont permis d'etudier et de moduler la specificite des cellules cytotoxiques in vivo et in vitro. Il faut determiner quel anticorps bispecifique sera capable in vivo de «cibler» certaines cellules cytotoxiques qui pourront avoir des applications ...
D M, Segal, D P, Snider
openaire   +2 more sources

Specific tumoricidal activity of cytotoxic macrophages and cytotoxic lymphocytes

Cancer Immunology, Immunotherapy, 1986
The antitumor potency and specificity of syngeneic immune peritoneal exudate cells were tested. Groups of DBA/2 mice were immunized against syngeneic SL2 tumor cells. Then 6 days after the last immunization the antitumor potency, and the specificity of the immunization reaction was tested by injecting groups of the immunized mice with 10(3) to 5 X 10(7)
H F, Dullens, S, Schakenraad, A, Oostdijk, W, Vuist, M, Van der Maas, W, Den Otter   +5 more
openaire   +2 more sources

Cytotoxic Activity Methods

2023
Natural products have formed the basis of traditional medicine systems throughout human history. Today, drug discovery studies from natural origins continue rapidly and efficiently with modern methods. Among the many activities, cytotoxic activity is related to the behaviour of test material on cell viability and cellular growth.
Esra Emerce, Kevser Taban Akça
openaire   +1 more source

Cytotoxic Activity of Lymphocytes

The Journal of Immunology, 1978
Abstract To detect the cellular origins of α-lymphotoxin (α-LT), we cultured various subpopulations of human blood lymphocytes separated by erythrocyte-rosetting techniques with various mitogens. T cell-enriched subpopulations responded to PHA by increased 3H-thymidine uptake into DNA and large amounts of α-LT production.
Keisuke Yano, Zoltan J Lucas
openaire   +2 more sources